04/12/2022
KEY FACTS ABOUT HERPS AND PERMANENT CURE.
The herpes simplex virus (HSV) is categorized into 2 types: HSV-1 and HSV-2.
HSV-1 is mainly transmitted by oral-to-oral contact, causing oral herpes (including symptoms known as cold sores), but it can also lead to ge***al herpes.
HSV-2 is a s*xually transmitted infection that causes ge***al herpes.
An estimated 3.7 billion people under age 50 (67%) have HSV-1 infection globally.
An estimated 491 million people aged 15–49 (13%) worldwide have HSV-2 infection.
Most HSV infections are asymptomatic, but symptoms of herpes include painful blisters or ulcers that can recur over time.
Infection with HSV-2 increases the risk of acquiring and transmitting HIV infection.
Overview
Infection with herpes simplex virus (HSV), known as herpes, is common globally. HSV type 1 (HSV-1) is typically transmitted by oral-to-oral contact and causes infection in or around the mouth (oral herpes), but it can also cause ge***al herpes. HSV-2 is mainly s*xually transmitted and causes ge***al herpes.
Both oral and ge***al herpes are mostly asymptomatic or unrecognized but can cause painful blisters or ulcers at the site of infection, ranging from mild to severe. Infection is lifelong, and symptoms can recur over many years. Some medications are available to reduce the severity and frequency of symptoms, but they cannot cure the infection.
Recurrent symptoms of both oral and ge***al herpes may be distressing. Ge***al herpes can also be stigmatizing and have an impact on s*xual relationships. However, in time, most people with either kind of herpes adjust to living with the infection.
Scope of the problem
In 2016 (last available estimates), 3.7 billion people under the age of 50, or 67% of the population, had HSV-1 infection (oral or ge***al). Most HSV-1 infections are acquired during childhood.
Ge***al herpes caused by HSV-2 affects an estimated 491 million (13%) people aged 15–49 years worldwide (2016 data). HSV-2 infects women almost twice as often as men because s*xual transmission is more efficient from men to women. Prevalence increases with age, though the highest number of new infections are in adolescents.
Signs and symptoms
Oral herpes infection is mostly asymptomatic, but symptoms can include painful blisters or open sores (ulcers) in or around the mouth (cold sores). Infected persons will often experience a tingling, itching or burning sensation around their mouth before the appearance of sores. These symptoms can recur periodically, and the frequency varies from person to person.
Ge***al herpes can be asymptomatic or have mild symptoms that go unrecognized. When symptoms occur, ge***al herpes is characterised by one or more ge***al or a**l blisters or ulcers. Additionally, symptoms of a new infection often include fever, body aches and swollen lymph nodes. After an initial episode, which can be severe, symptoms may recur. Ge***al herpes caused by HSV-1 typically does not recur frequently. With HSV-2, recurrent symptoms are common. However, recurrences are often less severe than the first episode and tend to decrease over time.
Transmission
HSV-1 is mainly transmitted via contact with the virus in sores, saliva or surfaces in or around the mouth. Less commonly, HSV-1 can be transmitted to the ge***al area through oral-ge***al contact to cause ge***al herpes. It can be transmitted from oral or skin surfaces that appear normal; however, the greatest risk of transmission is when there are active sores. People who already have HSV-1 are not at risk of reinfection, but they are still at risk of acquiring HSV-2.
HSV-2 is mainly transmitted during s*x through contact with ge***al or a**l surfaces, skin, sores or fluids of someone infected with the virus. HSV-2 can be transmitted even if the skin looks normal and is often transmitted in the absence of symptoms.
In rare circumstances, herpes (HSV-1 and HSV-2) can be transmitted from mother to child during delivery, causing neonatal herpes.
Possible complications
HSV-2 and HIV infection
HSV-2 infection increases the risk of acquiring HIV infection by approximately three-fold. Additionally, people with both HIV and HSV-2 infection are more likely to spread HIV to others. HSV-2 infection is among the most common infections in people living with HIV.
Severe disease
In immunocompromised people, including those with advanced HIV infection, herpes can have more severe symptoms and more frequent recurrences. Rare complications of HSV-2 include meningoencephalitis (brain infection) and disseminated infection. Rarely, HSV-1 infection can lead to more severe complications such as encephalitis (brain infection) or keratitis (eye infection).
Neonatal herpes
Neonatal herpes can occur when an infant is exposed to HSV during delivery. Neonatal herpes is rare, occurring in an estimated 10 out of every 100 000 births globally. However, it is a serious condition that can lead to lasting neurologic disability or death. The risk for neonatal herpes is greatest when a mother acquires HSV for the first time in late pregnancy.
WHO recommended treatment.
Antiviral medications – such as acyclovir, famciclovir and valacyclovir – are the most effective medications but doesn't cure herps permanently.
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