De Etta-Pharm. Enterprise

04/07/2025

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02/07/2025

50 𝗖𝗢𝗠𝗠𝗢𝗡𝗟𝗬 𝗨𝗦𝗘𝗗 𝗗𝗥𝗨𝗚𝗦 𝗪𝗜𝗧𝗛 𝗧𝗛𝗘𝗜𝗥 𝗨𝗦𝗘, 𝗗𝗢𝗦𝗘 & 𝗦𝗜𝗗𝗘 𝗘𝗙𝗙𝗘𝗖𝗧

1. 𝗜𝗯𝘂𝗽𝗿𝗼𝗳𝗲𝗻:
- Use: Pain relief, anti-inflammatory.
- Dose: Usually 200-400 mg every 4-6 hours as needed.
- Side Effects: Stomach upset, ulcers, dizziness.

2. 𝗔𝗺𝗼𝘅𝗶𝗰𝗶𝗹𝗹𝗶𝗻:
- Use: Antibiotic for bacterial infections.
- Dose: Varies based on the infection, typically 500 mg every 8 hours.
- Side Effects: Nausea, diarrhea, rash.

3. 𝗟𝗶𝘀𝗶𝗻𝗼𝗽𝗿𝗶𝗹:
- Use: High blood pressure, heart failure.
- Dose: Usually 10-40 mg once a day.
- Side Effects: Dizziness, cough, kidney problems.

4. 𝗟𝗼𝗿𝗮𝘇𝗲𝗽𝗮𝗺:
- Use: Anxiety disorders, insomnia.
- Dose: 1-2 mg, 2-3 times a day.
- Side Effects: Drowsiness, confusion, dependency with long-term use.

5. 𝗦𝗶𝗺𝘃𝗮𝘀𝘁𝗮𝘁𝗶𝗻:
- Use: Lowering cholesterol levels.
- Dose: 10-40 mg once a day in the evening.
- Side Effects: Muscle pain, liver problems, digestive issues.

6. 𝗢𝗺𝗲𝗽𝗿𝗮𝘇𝗼𝗹𝗲:
- Use: Gastroesophageal reflux disease (GERD), stomach ulcers.
- Dose: 20 mg once a day, before a meal.
- Side Effects: Headache, nausea, vitamin B12 deficiency with long-term use.

7. 𝗠𝗲𝘁𝗳𝗼𝗿𝗺𝗶𝗻:
- Use: Type 2 diabetes.
- Dose: Typically starts at 500 mg or 850 mg once or twice a day.
- Side Effects: Gastrointestinal upset, lactic acidosis (rare but serious).

8. 𝗔𝗹𝗯𝘂𝘁𝗲𝗿𝗼𝗹:
- Use: Asthma, chronic obstructive pulmonary disease (COPD).
- Dose: Inhalation, 1-2 puffs every 4-6 hours as needed.
- Side Effects: Increased heart rate, tremors, headache.

9. 𝗦𝗲𝗿𝘁𝗿𝗮𝗹𝗶𝗻𝗲:
- Use: Depression, anxiety disorders, obsessive-compulsive disorder (OCD).
- Dose: Usually starts at 50 mg once a day, can be increased.
- Side Effects: Nausea, insomnia, sexual dysfunction.

10. 𝗪𝗮𝗿𝗳𝗮𝗿𝗶𝗻:
- Use: Blood thinning to prevent clots.
- Dose: Individualized based on blood tests, typically 2-10 mg once a day.
- Side Effects: Bleeding (risk of excessive bleeding), interactions with many other drugs and foods.

11. 𝗔𝗰𝗲𝘁𝗮𝗺𝗶𝗻𝗼𝗽𝗵𝗲𝗻 (𝖳𝗒𝗅𝖾𝗇𝗈𝗅):
- Use: Pain relief, fever reduction.
- Dose: Typically 500-1000 mg every 4-6 hours as needed.
- Side Effects: Liver damage (with high doses or prolonged use), allergic reactions.

12. Citalopram:
- Use: Depression, panic disorder.
- Dose: Usually starts at 20 mg once a day, can be increased.
- Side Effects: Nausea, drowsiness, sexual dysfunction.

13. 𝗟𝗲𝘃𝗼𝘁𝗵𝘆𝗿𝗼𝘅𝗶𝗻𝗲:
- Use: Hypothyroidism (underactive thyroid).
- Dose: Individualized based on thyroid function tests, usually taken once a day in the morning.
- Side Effects: Overdosing can lead to hyperthyroidism symptoms, such as rapid heartbeat and insomnia.

14. 𝗛𝘆𝗱𝗿𝗼𝗰𝗵𝗹𝗼𝗿𝗼𝘁𝗵𝗶𝗮𝘇𝗶𝗱𝗲:
- Use: High blood pressure, edema (fluid retention).
- Dose: 12.5-50 mg once a day.
- Side Effects: Electrolyte imbalance (low potassium levels), increased urination.

15. 𝗥𝗮𝗻𝗶𝘁𝗶𝗱𝗶𝗻𝗲:
- Use: Heartburn, stomach ulcers.
- Dose: 150 mg twice a day or 300 mg once a day.
- Side Effects: Headache, constipation, diarrhea.

16. 𝗗𝗶𝗮𝘇𝗲𝗽𝗮𝗺:
- Use: Anxiety disorders, muscle spasms, alcohol withdrawal.
- Dose: Varies based on the condition, typically 2-10 mg, 2-4 times a day.
- Side Effects: Drowsiness, dizziness, dependence with long-term use.

17. 𝗠𝗲𝘁𝗼𝗽𝗿𝗼𝗹𝗼𝗹:
- Use: High blood pressure, angina, heart failure.
- Dose: Varies based on the condition, usually 25-200 mg once a day.
- Side Effects: Fatigue, slow heart rate, low blood pressure.

18. 𝗙𝗹𝘂𝗼𝘅𝗲𝘁𝗶𝗻𝗲:
- Use: Depression, panic disorder, bulimia nervosa.
- Dose: Usually starts at 20 mg once a day, can be increased.
- Side Effects: Nausea, insomnia, sexual dysfunction.

19. 𝗣𝗿𝗲𝗱𝗻𝗶𝘀𝗼𝗻𝗲:
- Use: Inflammatory conditions, allergies, autoimmune disorders.
- Dose: Varies widely based on the condition, typically 5-60 mg per day.
- Side Effects: Weight gain, mood swings, increased risk of infections.

20. Gabapentin:
- Use: Nerve pain, seizures, restless legs syndrome.
- Dose: Varies based on the condition, usually starts at 300 mg, 3 times a day.
- Side Effects: Dizziness, drowsiness, swelling of extremities.

16. 𝗗𝗶𝗮𝘇𝗲𝗽𝗮𝗺:
- Use: Anxiety disorders, muscle spasms, alcohol withdrawal.
- Dose: Varies based on the condition, typically 2-10 mg, 2-4 times a day.
- Side Effects: Drowsiness, dizziness, dependence with long-term use.

17. 𝗠𝗲𝘁𝗼𝗽𝗿𝗼𝗹𝗼𝗹:
- Use: High blood pressure, angina, heart failure.
- Dose: Varies based on the condition, usually 25-200 mg once a day.
- Side Effects: Fatigue, slow heart rate, low blood pressure.

18. 𝗙𝗹𝘂𝗼𝘅𝗲𝘁𝗶𝗻𝗲:
- Use: Depression, panic disorder, bulimia nervosa.
- Dose: Usually starts at 20 mg once a day, can be increased.
- Side Effects: Nausea, insomnia, sexual dysfunction.

19. 𝗣𝗿𝗲𝗱𝗻𝗶𝘀𝗼𝗻𝗲:
- Use: Inflammatory conditions, allergies, autoimmune disorders.
- Dose: Varies widely based on the condition, typically 5-60 mg per day.
- Side Effects: Weight gain, mood swings, increased risk of infections.

20. Gabapentin:
- Use: Nerve pain, seizures, restless legs syndrome.
- Dose: Varies based on the condition, usually starts at 300 mg, 3 times a day.
- Side Effects: Dizziness, drowsiness, swelling of extremities.

21. 𝗔𝗺𝗹𝗼𝗱𝗶𝗽𝗶𝗻𝗲:
- Use: High blood pressure, angina (chest pain).
- Dose: Usually 5-10 mg once a day.
- Side Effects: Swelling in ankles/feet, dizziness, flushing.

22. 𝗔𝘁𝗼𝗿𝘃𝗮𝘀𝘁𝗮𝘁𝗶𝗻:
- Use: Lowering cholesterol levels.
- Dose: 10-80 mg once a day.
- Side Effects: Muscle pain, liver problems, digestive issues.

23. 𝗩𝗲𝗻𝗹𝗮𝗳𝗮𝘅𝗶𝗻𝗲:
- Use: Depression, anxiety disorders.
- Dose: Varies, often starts at 75 mg once a day.
- Side Effects: Nausea, drowsiness, increased blood pressure.

24. 𝗟𝗼𝗿𝗮𝘁𝗮𝗱𝗶𝗻𝗲:
- Use: Allergies.
- Dose: 10 mg once a day.
- Side Effects: Headache, dry mouth, fatigue.

25. 𝗠𝗼𝗿𝗽𝗵𝗶𝗻𝗲:
- Use: Severe pain (such as after surgery or injury), cancer pain.
- Dose: Varies widely based on the form of the drug and individual tolerance.
- Side Effects: Drowsiness, constipation, respiratory depression (slow breathing).

26. 𝗖𝗶𝗽𝗿𝗼𝗳𝗹𝗼𝘅𝗮𝗰𝗶𝗻:
- Use: Bacterial infections.
- Dose: Varies based on the type and severity of the infection, usually 250-750 mg every 12 hours.
- Side Effects: Nausea, diarrhea, tendon rupture (rare but serious).

27. 𝗘𝘀𝗰𝗶𝘁𝗮𝗹𝗼𝗽𝗿𝗮𝗺:
- Use: Depression, generalized anxiety disorder.
- Dose: Usually starts at 10 mg once a day, can be increased.
- Side Effects: Insomnia, drowsiness, sexual dysfunction.

28. 𝗢𝘅𝘆𝗰𝗼𝗱𝗼𝗻𝗲:
- Use: Moderate to severe pain.
- Dose: Varies based on the form of the drug and individual tolerance, often starts at 5 mg every 4-6 hours.
- Side Effects: Drowsiness, constipation, potential for addiction.

29. 𝗠𝗲𝘁𝗿𝗼𝗻𝗶𝗱𝗮𝘇𝗼𝗹𝗲:
- Use: Bacterial and protozoal infections.
- Dose: Varies based on the infection, typically 500 mg every 6 hours.
- Side Effects: Nausea, metallic taste in mouth, rare but serious allergic reactions.

30. 𝗥𝗶𝘀𝗽𝗲𝗿𝗶𝗱𝗼𝗻𝗲:
- Use: Schizophrenia, bipolar disorder, irritability associated with autistic disorder.
- Dose: Varies based on the condition, often starts at 0.5 mg once or twice a day.
- Side Effects: Drowsiness, weight gain, increased risk of stroke in elderly patients with dementia-related psychosis.

31. 𝗧𝗿𝗮𝗺𝗮𝗱𝗼𝗹:
- Use: Moderate to moderately severe pain.
- Dose: Typically 50-100 mg every 4-6 hours as needed.
- Side Effects: Dizziness, nausea, potential for dependence.

32. 𝗗𝘂𝗹𝗼𝘅𝗲𝘁𝗶𝗻𝗲:
- Use: Major depressive disorder, generalized anxiety disorder, chronic musculoskeletal pain.
- Dose: Usually starts at 30 mg once a day, can be increased.
- Side Effects: Nausea, dry mouth, increased sweating.

33. 𝗠𝗼𝗻𝘁𝗲𝗹𝘂𝗸𝗮𝘀𝘁:
- Use: Asthma, allergic rhinitis.
- Dose: 10 mg once a day in the evening.
- Side Effects: Headache, stomach pain, mood or behavior changes (rare).

34. 𝗖𝗮𝗿𝘃𝗲𝗱𝗶𝗹𝗼𝗹:
- Use: High blood pressure, heart failure.
- Dose: Varies based on the condition, often starts at 3.125 mg twice a day.
- Side Effects: Dizziness, fatigue, low blood pressure.

35. 𝗔𝗹𝗽𝗿𝗮𝘇𝗼𝗹𝗮𝗺:
- Use: Anxiety disorders, panic disorders.
- Dose: Varies based on the condition, often starts at 0.25 mg two to three times a day.
- Side Effects: Drowsiness, confusion, dependence with long-term use.

36. 𝗛𝘆𝗱𝗿𝗼𝗰𝗼𝗱𝗼𝗻𝗲/𝗔𝗰𝗲𝘁𝗮𝗺𝗶𝗻𝗼𝗽𝗵𝗲𝗻:
- Use: Severe pain relief.
- Dose: Varies based on the form and individual tolerance, often 5-10 mg of hydrocodone combined with 325-500 mg of acetaminophen every 4-6 hours as needed.
- Side Effects: Drowsiness, constipation, potential for dependence.

37. 𝗖𝗲𝗹𝗲𝗰𝗼𝘅𝗶𝗯:
- Use: Osteoarthritis, rheumatoid arthritis, acute pain.
- Dose: Usually 100-200 mg once a day.
- Side Effects: Stomach upset, headache, increased risk of cardiovascular events.

38. 𝗧𝗮𝗱𝗮𝗹𝗮𝗳𝗶𝗹:
- Use: Erectile dysfunction, benign prostatic hyperplasia.
- Dose: Varies based on the condition, often 5-20 mg once a day as needed.
- Side Effects: Headache, back pain, muscle aches.

39. 𝗥𝗼𝘀𝘂𝘃𝗮𝘀𝘁𝗮𝘁𝗶𝗻:
- Use: Lowering cholesterol levels.
- Dose: Usually 5-40 mg once a day.
- Side Effects: Muscle pain, liver problems, digestive issues.

40. 𝗟𝗲𝘃𝗲𝘁𝗶𝗿𝗮𝗰𝗲𝘁𝗮𝗺:
- Use: Epilepsy, seizures.
- Dose: Varies based on the condition, often starts at 500 mg twice a day.
- Side Effects: Drowsiness, weakness, mood changes.

41. 𝗥𝗮𝗻𝗶𝘁𝗶𝗱𝗶𝗻𝗲:
- Use: Heartburn, stomach ulcers.
- Dose: 150 mg twice a day or 300 mg once a day.
- Side Effects: Headache, constipation, diarrhea.

42. 𝗖𝗲𝘁𝗶𝗿𝗶𝘇𝗶𝗻𝗲:
- Use: Allergies, hay fever.
- Dose: 5-10 mg once a day.
- Side Effects: Drowsiness (though less common than with older antihistamines), dry mouth.

43. 𝗘𝘀𝗼𝗺𝗲𝗽𝗿𝗮𝘇𝗼𝗹𝗲:
- Use: Gastroesophageal reflux disease (GERD), stomach ulcers.
- Dose: 20-40 mg once a day.
- Side Effects: Headache, nausea, stomach pain.

44. 𝗠𝗲𝘁𝗵𝘆𝗹𝗽𝗵𝗲𝗻𝗶𝗱𝗮𝘁𝗲:
- Use: Attention deficit hyperactivity disorder (ADHD).
- Dose: Varies based on the specific medication (e.g., Concerta, Ritalin), often taken once or twice a day.
- Side Effects: Loss of appetite, insomnia, increased heart rate.

45. 𝗔𝗿𝗶𝗽𝗶𝗽𝗿𝗮𝘇𝗼𝗹𝗲:
- Use: Schizophrenia, bipolar disorder, major depressive disorder.
- Dose: Varies based on the condition, often starts at 10-15 mg once a day.
- Side Effects: Drowsiness, restlessness, weight gain.

46. 𝗘𝘀𝗼𝗺𝗲𝗽𝗿𝗮𝘇𝗼𝗹𝗲:
- Use: Gastroesophageal reflux disease (GERD), stomach ulcers.
- Dose: 20-40 mg once a day.
- Side Effects: Headache, nausea, stomach pain.

47. 𝗠𝗲𝘁𝗵𝘆𝗹𝗽𝗵𝗲𝗻𝗶𝗱𝗮𝘁𝗲:
- Use: Attention deficit hyperactivity disorder (ADHD).
- Dose: Varies based on the specific medication (e.g., Concerta, Ritalin), often taken once or twice a day.
- Side Effects: Loss of appetite, insomnia, increased heart rate.

48. 𝗔𝗿𝗶𝗽𝗶𝗽𝗿𝗮𝘇𝗼𝗹𝗲:
- Use: Schizophrenia, bipolar disorder, major depressive disorder.
- Dose: Varies based on the condition, often starts at 10-15 mg once a day.
- Side Effects: Drowsiness, restlessness, weight gain.

49. 𝗠𝗲𝘁𝗼𝗰𝗹𝗼𝗽𝗿𝗮𝗺𝗶𝗱𝗲:
- Use: Gastrointestinal disorders, nausea, vomiting.
- Dose: 10-15 mg, 3-4 times a day before meals.
- Side Effects: Drowsiness, restlessness, movement disorders.

50. 𝗢𝗹𝗮𝗻𝘇𝗮𝗽𝗶𝗻𝗲:
- Use: Schizophrenia, bipolar disorder.
- Dose: Varies based on the condition, often starts at 5-10 mg once a day.
- Side Effects: Weight gain, drowsiness, increased cholesterol levels.

51. 𝗗𝗲𝘅𝗮𝗺𝗲𝘁𝗵𝗮𝘀𝗼𝗻𝗲:
- Use: Inflammation, certain types of cancer, severe allergies.
- Dose: Varies based on the condition, often given as a low to moderate dose.
- Side Effects: Increased appetite, insomnia, mood swings.

52. 𝗟𝗮𝗻𝘀𝗼𝗽𝗿𝗮𝘇𝗼𝗹𝗲:
- Use: Gastroesophageal reflux disease (GERD), stomach ulcers.
- Dose: 15-30 mg once a day before a meal.
- Side Effects: Headache, diarrhea, stomach pain.

53. 𝗕𝘂𝗽𝗿𝗼𝗽𝗶𝗼𝗻:
- Use: Depression, smoking cessation.
- Dose: Varies based on the condition, often starts at 150 mg once or twice a day.
- Side Effects: Insomnia, dry mouth, seizures (rare but serious).

54. 𝗛𝘆𝗱𝗿𝗮𝗹𝗮𝘇𝗶𝗻𝗲:
- Use: High blood pressure, heart failure.
- Dose: Varies based on the condition, often starts at 10-50 mg four times a day.
- Side Effects: Dizziness, headache, rapid heartbeat.

55. 𝗖𝗶𝘁𝗮𝗹𝗼𝗽𝗿𝗮𝗺:
- Use: Depression, panic disorder.
- Dose: Usually starts at 20 mg once a day, can be increased.
- Side Effects: Nausea, drowsiness, sexual dysfunction.
De Etta-Pharm. Enterprise Facebook

23/11/2024

Good Morning
Good Evening
Good Afternoon

Greeting U According To Your Time and Location
De Etta-Pharm. Enterprise Facebook

19/11/2024

*𝐎𝐚𝐥 𝐑𝐞𝐡𝐲𝐝𝐫𝐚𝐭𝐢𝐨𝐧 𝐒𝐨𝐥𝐮𝐭𝐢𝐨𝐧)*

is a simple, effective, and inexpensive way to replenish fluids and electrolytes lost due to diarrhea, vomiting, or excessive sweating. Here's a homemade ORS recipe:

*𝐈𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐬:*

1. 1 liter of clean water
2. 1/2 teaspoon of salt (sodium chloride)
3. 6 teaspoons of sugar (sucrose or glucose)
4. Optional: 1/4 teaspoon of potassium chloride (or 1/2 banana, mashed)

*𝐈𝐧𝐬𝐭𝐫𝐮𝐜𝐭𝐢𝐨𝐧𝐬:*

1. Mix the salt and sugar in the water until dissolved.
2. Stir well.
3. Add potassium chloride (if using).
4. Stir again.
5. Store in a clean container.

*𝐓𝐢𝐩𝐬:*

1. Use a clean glass or plastic container.
2. Use measuring spoons for accuracy.
3. Use boiled or filtered water if possible.
4. Adjust sugar to taste (but maintain salt ratio).
5. Prepare fresh solution every 24 hours.

*𝐖𝐡𝐲 𝐭𝐡𝐞𝐬𝐞 𝐢𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐬?*

1. Salt (sodium): Replaces lost sodium.
2. Sugar (sucrose/glucose): Provides energy, helps absorption.
3. Potassium chloride (optional): Replaces lost potassium.

*When to use homemade ORS:*

1. Diarrhea or vomiting.
2. Excessive sweating.
3. Fever.
4. Dehydration symptoms (dry mouth, dark urine).

*Important:*

1. Consult a healthcare professional if symptoms persist or worsen.
2. For severe dehydration, seek medical attention.
3. This homemade ORS is not suitable for infants under 6 months.

*World Health Organization (WHO) ORS Recipe:*

The WHO recommends a slightly different recipe:

1. 1 liter of clean water
2. 2.6 grams of sodium chloride (about 1/2 teaspoon)
3. 13.5 grams of glucose (about 2.5 teaspoons)
4. 1.5 grams of potassium chloride (about 1/4 teaspoon)

Adjust the recipe according to your needs and consult a healthcare professional if unsure.

Stay hydrated and healthy!

10/11/2024

𝐌𝐘 𝐅𝐄𝐋𝐋𝐎𝐖 𝐌𝐄𝐍, 𝐃𝐨𝐧'𝐭 𝐋𝐞𝐭 𝐀 𝐩𝐢𝐥𝐥 𝐬𝐭𝐞𝐚𝐥 𝐘𝐨𝐮𝐫 𝐅𝐮𝐭𝐮𝐫𝐞.

Abusing 𝐒𝐢𝐥𝐝𝐞𝐧𝐚𝐟𝐢𝐥 is a shortcut to long-term health problems.
How do I mean?

𝐖𝐡𝐚𝐭 𝐃𝐫𝐮𝐠 𝐈𝐬 𝐒𝐢𝐥𝐝𝐞𝐧𝐚𝐟𝐢𝐥?

Before we learn about this drug, let me bring your knowledge to some common brands; vi**ra, vega, kifaru, Man G, etc.

Sildenafil is a medication used for treating erectile dysfunction (ED).

In the treatment of 𝐄𝐫𝐞𝐜𝐭𝐢𝐥𝐞 𝐃𝐲𝐬𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧, it helps to achieve an er****on significant enough for sexual in*******se.

When prescribed, it is usually advised to take it about 1 hour before sexual activity and sufficient arousal and stimulation is also recommended.

𝐇𝐎𝐖 𝐃𝐎𝐄𝐒 𝐈𝐓 𝐖𝐎𝐑𝐊?
This may sound a little medical, but it's important to pick a thing or two to learn;

Sildenafil is from the family of drugs called PDE5 inhibitors.

This is what happens on a normal day ;During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum of the p***s.

Nitric oxide goes ahead to activate an enzyme which increases level of a substance called cGMP
The presence of this cGMP leads to the relaxation of smooth muscle and increases blood flow to the p***s, resulting in an er****on.

A particular enzyme called PDE5 breaks down the cGMP that enables this needed relaxation and blood flow.When PDE5 does this, er****on is disrupted.

Now, this is where Sildenafil comes in.

It stops 𝐏𝐃𝐄5 from doing this and allows the normal process to occur.

Once the effect of Sildenafil wears out, the 𝐏𝐃𝐄5 enzyme resumes work again.

This is why most men keep taking the pill when the root cause is not identified and eliminated.

To tackle 𝐄𝐫𝐞𝐜𝐭𝐢𝐥𝐞 𝐃𝐲𝐬𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧, it is always advised to see a healthcare provider first, and understand the actual cause of the condition.

-If it's a hormonal issue involving testosterone status, hormonal treatment will be introduced to tackle the condition
-If it's psychological such as; depression, PTSD, performance anxiety, and widower syndrome, appropriate therapy will be given
-It could occur due to pe**le disorders like; Peyronie disease and Epispadias
-It could also be as a result of nutritional deficiency, such as ; zinc deficiency and other form of malnutrition.
-It could be as a result of blood diseases, systemic and endocrine diseases that your doctor is likely to spot.
-Using Sildenafil alone without fixing the root cause of ED, will lead to overuse and this will result in serious undesired effects.

𝐖𝐇𝐀𝐓 𝐀𝐑𝐄 𝐓𝐇𝐄 𝐒𝐈𝐃𝐄 𝐄𝐅𝐅𝐄𝐂𝐓𝐒
-Headache: most common
-Indigestion
-Nasal congestion
-Back pain
-Muscle pain
-Dizziness
-Visual disturbances

Overuse of Sildenafil can lead to more complicated effects like;
-Priapism ; a prolonged er****on lasting more than 4 hours and usually painful
-Sudden Hearing loss
-Sudden loss of vision
-Chest pain radiating to the shoulder and jaw (May feel like a Heart attack)

𝐖𝐇𝐎 𝐒𝐇𝐎𝐔𝐋𝐃 𝐍𝐎𝐓 𝐔𝐒𝐄 𝐓𝐇𝐄 𝐃𝐑𝐔𝐆?

-People with severe liver disease
-People with severe heart disorder
-People with low BP
-People who just had a stroke
-People who just had a recent heart attack

01/11/2024

01/11/2024

𝐏𝐨𝐧𝐬𝐞𝐠𝐫𝐨𝐦𝐚𝐛
, a type of drug known as a monoclonal antibody, targets a protein called GDF-15. Several drugs targeting GDF-15 or another that it interacts with in the brain, called GFRAL, are in development as possible treatments for cachexia, but ponsegromab is the first to advance this far in clinical trials.

No drugs are approved in the United States or Europe to treat cachexia, so the results with ponsegromab represent “a big breakthrough in the field of cancer cachexia research,” said Richard Dunne, M.D., of the Wilmot Cancer Center in New York and an investigator on the trial.

In a press release, Pfizer—which makes 𝐩𝐨𝐧𝐬𝐞𝐠𝐫𝐨𝐦𝐚𝐛 and funded the trial—said it is planning to launch a larger trial of the drug next year in people with cancer and cachexia. If the trial produces similarly positive results, it could lead to the drug’s approval by the Food and Drug Administration.

𝐀 𝐝𝐞𝐬𝐩𝐞𝐫𝐚𝐭𝐞 𝐧𝐞𝐞𝐝 𝐟𝐨𝐫 𝐚𝐧 𝐞𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞 𝐜𝐚𝐜𝐡𝐞𝐱𝐢𝐚 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭

Cachexia has long been considered an almost insurmountable problem in people with cancer, usually those with advanced disease. It's also commonly seen in several other health conditions, including heart failure and chronic obstructive pulmonary disease, or COPD.

In its most severe form, with muscle and fat slipping away over a period of months for no apparent reason, it can cause extreme weakness and fatigue, along with unwelcome changes in skin color and overall physical appearance. Its physiologic impact, particularly on the lungs and heart, can lead directly to death.

Although it can occur in many types of cancer, cachexia most commonly occurs in people with pancreatic, colorectal, lung, and head and neck cancers, as well as some blood cancers and sarcomas.

According to E. Ramsay Camp, M.D., of Baylor College of Medicine’s Dan L. Duncan Comprehensive Cancer Center, for oncologists like him who specialize in treating pancreatic and other cancers in which cachexia is common, the condition is always top of mind.

“One of the first things I ask new patients [with these cancers] is whether they’ve lost weight,” said Dr. Camp, who was not involved in the trial. Any weight loss could be a sign that cachexia is starting to set in. Even in people whose cancer is still in early stages, a loss of muscle and fat can affect their ability to tolerate and complete their treatments, he explained.

“Patients often ask me what they can do to help” with their treatment, he said. “And my number one comment is always to maintain your weight, because [your] cancer treatments will take a toll.”

𝐓𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐆𝐃𝐅-15 𝐚𝐧𝐝 𝐆𝐅𝐑𝐀𝐋, 𝐚 𝐁𝐫𝐚𝐢𝐧 𝐍𝐞𝐮𝐫𝐨𝐧

For years, researchers struggled to understand cachexia's biological underpinnings—what happens in cells and organ systems that causes muscle to deteriorate and squelches people’s desire and ability to eat.

Over the last decade, however, cachexia researchers have made substantial headway in understanding the biologic players involved in cachexia and identified some tangible leads for possible treatments.
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31/10/2024

𝐒𝐥𝐢𝐝𝐞 𝐈𝐧 𝐰𝐢𝐭𝐡 𝐚 𝐟𝐨𝐥𝐥𝐨𝐰 𝐅𝐨𝐫 𝐌𝐨𝐫𝐞 𝐢𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐥𝐢𝐤𝐞 𝐭𝐡𝐢𝐬

𝐏𝐑𝐄𝐒𝐄𝐍𝐓𝐀𝐓𝐈𝐎𝐍 ON 𝐌𝐈𝐆𝐑𝐀𝐈𝐍𝐄 𝐇𝐄𝐀𝐃𝐀𝐂𝐇𝐄𝐒

Migraine Headaches: Understanding the Causes, Symptoms, and Treatment Options

𝐈𝐍𝐓𝐑𝐎𝐃𝐔𝐂𝐓𝐈𝐎𝐍:

- Definition: A migraine is a neurological disorder characterized by recurrent episodes of severe headaches, often accompanied by sensitivity to light, sound, and nausea.
- Prevalence: Affects approximately 38 million people in the United States, with women 3 times more likely to experience migraines than men.

𝐂𝐀𝐔𝐒𝐄𝐒 𝐀𝐍𝐃 𝐓𝐑𝐈𝐆𝐆𝐄𝐑𝐒:

- Genetic predisposition
- Hormonal changes (menstruation, menopause)
- Stress
- Sensory stimuli (light, sound, smell)
- Certain foods (chocolate, citrus, MSG)
- Sleep disturbances
- Environmental factors (weather, altitude)

*SYMPTOMS:*

- Severe, throbbing headache (usually one-sided)
- Sensitivity to light, sound, and smell
- Nausea and vomiting
- Dizziness and vertigo
- Tingling or numbness in face and extremities
- Aura symptoms (visual disturbances, zigzag patterns)

*𝐏𝐇𝐀𝐒𝐄𝐒 𝐎𝐅 𝐀 𝐌𝐈𝐆𝐑𝐀𝐈𝐍𝐄:*

1. Prodrome (warning signs): irritability, fatigue, mood changes
2. Aura (visual disturbances): zigzag patterns, blind spots
3. Headache phase: severe pain, sensitivity to stimuli
4. Postdrome (recovery): fatigue, mood changes

*𝐃𝐈𝐀𝐆𝐍𝐎𝐒𝐈𝐒:*

- Medical history and physical examination
- Headache diary or journal
- Imaging tests (MRI, CT scan) to rule out other conditions
- Diagnostic criteria: frequency, severity, duration, and symptoms

𝐓𝐑𝐄𝐀𝐓𝐌𝐄𝐍𝐓 𝐎𝐏𝐓𝐈𝐎𝐍�

- Acute treatments:
- Over-the-counter pain relievers (ibuprofen, acetaminophen)
- Triptans (sumatriptan, rizatriptan)
- Ergotamines (ergotamine, dihydroergotamine)
- Preventive treatments:
- Beta blockers (propranolol, metoprolol)
- Anticonvulsants (topiramate, valproate)
- Antidepressants (amitriptyline, fluoxetine)
- Lifestyle modifications:
- Stress management
- Sleep hygiene
- Dietary changes

LIFESTYLE CHANGES:

- Maintain a consistent sleep schedule
- Exercise regularly
- Manage stress through relaxation techniques (meditation, yoga)
- Avoid triggers (certain foods, sensory stimuli)
- Stay hydrated

CONCLUSION:

- Migraines are complex, multifactorial disorders requiring comprehensive management.
- Accurate diagnosis and treatment can significantly improve quality of life.
- Lifestyle modifications and preventive treatments can reduce frequency and severity.

*REFERENCES:*
𝐈
- American Migraine Foundation (AMF)
- National Headache Foundation (NHF)
- Mayo Clinic: Migraines

31/10/2024

𝐏𝐑𝐄𝐒𝐄𝐍𝐓𝐀𝐓𝐈𝐎𝐍 ON 𝐌𝐈𝐆𝐑𝐀𝐈𝐍𝐄 𝐇𝐄𝐀𝐃𝐀𝐂𝐇𝐄𝐒

Migraine Headaches: Understanding the Causes, Symptoms, and Treatment Options

𝐈𝐍𝐓𝐑𝐎𝐃𝐔𝐂𝐓𝐈𝐎𝐍:

- Definition: A migraine is a neurological disorder characterized by recurrent episodes of severe headaches, often accompanied by sensitivity to light, sound, and nausea.
- Prevalence: Affects approximately 38 million people in the United States, with women 3 times more likely to experience migraines than men.

𝐂𝐀𝐔𝐒𝐄𝐒 𝐀𝐍𝐃 𝐓𝐑𝐈𝐆𝐆𝐄𝐑𝐒:

- Genetic predisposition
- Hormonal changes (menstruation, menopause)
- Stress
- Sensory stimuli (light, sound, smell)
- Certain foods (chocolate, citrus, MSG)
- Sleep disturbances
- Environmental factors (weather, altitude)

*SYMPTOMS:*

- Severe, throbbing headache (usually one-sided)
- Sensitivity to light, sound, and smell
- Nausea and vomiting
- Dizziness and vertigo
- Tingling or numbness in face and extremities
- Aura symptoms (visual disturbances, zigzag patterns)

*𝐏𝐇𝐀𝐒𝐄𝐒 𝐎𝐅 𝐀 𝐌𝐈𝐆𝐑𝐀𝐈𝐍𝐄:*

1. Prodrome (warning signs): irritability, fatigue, mood changes
2. Aura (visual disturbances): zigzag patterns, blind spots
3. Headache phase: severe pain, sensitivity to stimuli
4. Postdrome (recovery): fatigue, mood changes

*𝐃𝐈𝐀𝐆𝐍𝐎𝐒𝐈𝐒:*

- Medical history and physical examination
- Headache diary or journal
- Imaging tests (MRI, CT scan) to rule out other conditions
- Diagnostic criteria: frequency, severity, duration, and symptoms

𝐓𝐑𝐄𝐀𝐓𝐌𝐄𝐍𝐓 𝐎𝐏𝐓𝐈𝐎𝐍�

- Acute treatments:
- Over-the-counter pain relievers (ibuprofen, acetaminophen)
- Triptans (sumatriptan, rizatriptan)
- Ergotamines (ergotamine, dihydroergotamine)
- Preventive treatments:
- Beta blockers (propranolol, metoprolol)
- Anticonvulsants (topiramate, valproate)
- Antidepressants (amitriptyline, fluoxetine)
- Lifestyle modifications:
- Stress management
- Sleep hygiene
- Dietary changes

LIFESTYLE CHANGES:

- Maintain a consistent sleep schedule
- Exercise regularly
- Manage stress through relaxation techniques (meditation, yoga)
- Avoid triggers (certain foods, sensory stimuli)
- Stay hydrated

CONCLUSION:

- Migraines are complex, multifactorial disorders requiring comprehensive management.
- Accurate diagnosis and treatment can significantly improve quality of life.
- Lifestyle modifications and preventive treatments can reduce frequency and severity.

*REFERENCES:*
𝐈
- American Migraine Foundation (AMF)
- National Headache Foundation (NHF)
- Mayo Clinic: Migraines

22/10/2024

𝐓𝐨𝐝𝐚𝐲 𝐖𝐞 𝐖𝐨𝐮𝐥𝐝 𝐁𝐞 𝐓𝐚𝐥𝐤𝐢𝐧𝐠 𝐀𝐛𝐭 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐃𝐫𝐮𝐠𝐬.

𝐅𝐢𝐫𝐬𝐭, 𝐖𝐡𝐚𝐭 𝐚𝐫𝐞 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐃𝐫𝐮𝐠𝐬 ?

𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐝𝐫𝐮𝐠𝐬 are medications used to treat life-threatening medical conditions or situations that require immediate attention. Here's an overview:

*𝐓𝐲𝐩𝐞𝐬 𝐨𝐟 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐃𝐫𝐮𝐠𝐬:*

1. 𝐂𝐚𝐫𝐝𝐢𝐚𝐜 𝐚𝐫𝐫𝐞𝐬𝐭 𝐝𝐫𝐮𝐠𝐬:
- Epinephrine (adrenaline)
- Atropine
- Lidocaine

2. 𝐀𝐧𝐚𝐩𝐡𝐲𝐥𝐚𝐱𝐢𝐬 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭:
- Epinephrine auto-injectors (EpiPen)
- Antihistamines (diphenhydramine)

3. 𝐒𝐞𝐢𝐳𝐮𝐫𝐞 𝐜𝐨𝐧𝐭𝐫𝐨𝐥:
- Benzodiazepines (diazepam, lorazepam)
- Phenytoin
4. Allergic reactions:
- Corticosteroids (prednisone)
- Antihistamines (diphenhydramine)
5. 𝐎𝐯𝐞𝐫𝐝𝐨𝐬𝐞 𝐫𝐞𝐯𝐞𝐫𝐬𝐚𝐥:
- Naloxone (opioid overdose)
- Flumazenil (benzodiazepine overdose)
6. 𝐑𝐞𝐬𝐩𝐢𝐫𝐚𝐭𝐨𝐫𝐲 𝐃𝐢𝐬𝐭𝐫𝐞𝐬𝐬:
- Bronchodilators (albuterol)
- Oxygen therapy

*𝐂𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐬𝐭𝐢𝐜𝐬 𝐨𝐟 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐃𝐫𝐮𝐠𝐬:*

1. Fast-acting
2. High potency
3. Specific dosing instructions
4. Potential side effects
5. Requires medical supervision

*𝐀𝐝𝐦𝐢𝐧𝐢𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐑𝐨𝐮𝐭𝐞𝐬:*

1. Intravenous (IV)
2. Intramuscular (IM)
3. Subcutaneous (SC)
4. Oral
5. Inhalation

*𝐄𝐱𝐚𝐦𝐩𝐥𝐞𝐬 𝐨𝐟 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐒𝐢𝐭𝐮𝐚𝐭𝐢𝐨𝐧𝐬:*

1. Cardiac arrest
2. Anaphylaxis
3. Seizures
4. Allergic reactions
5. Overdose
6. Respiratory distress
7. Trauma

*𝐈𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐭 𝐂𝐨𝐧𝐬𝐢𝐝𝐞𝐫𝐚𝐭𝐢𝐨𝐧𝐬:*

1. Only administer emergency drugs under medical supervision.
2. Follow proper dosing and administration guidelines.
3. Monitor patient's vital signs and response.
4. Be aware of potential interactions with other medications.
*𝐂𝐨𝐦𝐦𝐨𝐧 𝐄𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐲 𝐃𝐫𝐮𝐠 𝐁𝐫𝐚𝐧𝐝𝐬:*
1. EpiPen (epinephrine)
2. Narcan (naloxone)
3. Va**um (diazepam)
4. Atropen (atropine)
5. Albuterol inhalers

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