25/08/2025
🚺 INFERTILITY:
✅Definition:
Infertility is defined as the inability of a couple to conceive after 12 months of regular, unprotected sexual in*******se.
Primary infertility: When pregnancy has never occurred.
Secondary infertility: When pregnancy occurred previously but not now.
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✅Causes:
1. Female factors (40–50%)
Ovulatory disorders (e.g., PCOS, thyroid disorders, hyperprolactinemia).
Tubal factors (e.g., tubal blockage due to pelvic inflammatory disease, endometriosis).
Uterine factors (fibroids, congenital anomalies, adhesions).
Cervical factors (cervical mucus hostility).
2. Male factors (30–40%)
Low s***m count (oligos***mia), absent s***m (azoos***mia).
Poor motility (asthenozoos***mia).
Abnormal morphology (teratozoos***mia).
Varicocele, infections, hormonal imbalance.
3. Unexplained infertility (10–15%)
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✅Investigations:
History & examination of both partners.
1.Male partner:
Semen analysis (first-line test).
2.Female partner:
Ovulation tests (basal body temp charting, serum progesterone, LH kits).
Ultrasound for follicular study.
HSG (Hysterosalpingography) / Sonohysterography for tubal patency.
Laparoscopy & hysteroscopy if needed.
Hormonal assays (FSH, LH, prolactin, TSH, AMH).
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✅Management:
1. General measures
Counseling both partners.
Lifestyle modification (weight control, avoid smoking, alcohol, stress).
2. Male factor
Treat underlying cause (infection, varicocele, endocrine).
Assisted reproductive techniques (IUI, IVF, ICSI).
3. Female factor
Ovulation induction (clomiphene citrate, letrozole, gonadotropins).
Surgical correction (laparoscopy for endometriosis, tuboplasty).
ART (IUI, IVF, ICSI, surrogacy).
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✅Complications:
Emotional stress, depression, anxiety.
Financial burden due to prolonged treatments.
Risk of multiple pregnancy with ovulation induction/ART.