House of Health

19/12/2025

Research Wins, Community Perks & a Little Surprise Inside - https://mailchi.mp/houseofhealth/2025-round-up-6429578

16/12/2025

We’ve Been Quiet. Not Idle. Let’s Catch Up 👀 - https://mailchi.mp/houseofhealth/2025-round-up-6421271

09/12/2025

Are you interested in Breath Testing? We are conducting a small study in the Auckland Gut Clinic and need people with digestive symptoms (who meet breath testing criteria - the test is offered at a 50% discount) and healthy controls. Please email reception@houseofhealth.co.nz for the participant information sheet. NZ HDEC Ethics reference: 2025 EXP 24271

06/12/2025

Big News: A Major Breakthrough in Hydrogen Science
Fresh off the press this week!
​Just-released paper in Redox Biology (5-Year IF 13.1, SCImago Q1) is a milestone for the entire hydrogen field.

For years, researchers and many of you have asked fundamental questions:

How does H2 work?
What does it actually bind to?
Why do its effects last long after the gas is gone?
How does it benefit the mitochondria?
And so on…
This publication provides a major part of the answer.

Read the press release: https://molecularhydrogeninstitute.org/study-identifies-first-molecular-target-of-hydrogen/

Read the published paper here:
https://www.sciencedirect.com/science/article/pii/S2213231725004653?via%3Dihub

What the Study Found
The study discovered that exposure to molecular hydrogen targets the Rieske iron-sulfur protein (RISP), triggering its LONP1-mediated degradation RISP is a critical component of mitochondrial Complex III. Hydrogen suppresses Complex III activity within minutes, signaling the cell that something has changed. This triggers a controlled mitochondrial hormetic response, a repair-and-strengthen cycle that mitochondria naturally use to stay resilient.

The cell responds by rebuilding and upregulating RISP, restoring and even enhancing function within hours.
This mechanism neatly explains many of the “paradoxical” findings in hydrogen research why some markers go up, others go down, yet outcomes typically improve.
This is an elegant unifying mechanism, indicating hydrogen is not biologically inert but like other small biological gases (NO⋅, CO, H₂S) but with its own unique twist.

This paper:

Further moves the field beyond the old “antioxidant” narrative
Shows that hydrogen interacts with a conserved mitochondrial protein
Helps explain the diverse and long-lasting effects seen across preclinical and clinical studies
This is the kind of work that shifts an entire field forward.

A groundbreaking paper published this week in Redox Biology reveals the first clearly defined molecular target of molecular hydrogen (H₂).

06/12/2025

Molecular Hydrogen.
Its such an important gas. Link to generators for personal use in the comments.
https://www.facebook.com/share/p/1WNEQJU9Bs/

19/11/2025

Switching to a healthier way of eating isn't too hard .

It is increasing our risk of a range of chronic diseases, including obesity and depression, a major review says.

31/10/2025

Hormonal contraceptives under the spotlight.

In a nationwide Swedish study of over 2 million girls and women followed up for more than 21 million person-years, the use of hormonal contraceptives was associated with a 24% increased risk for breast cancer, with both combined and progestin-only formulations associated with increased risk. http://ms.spr.ly/6187tEdwW

31/10/2025

Users of e-cigarettes had increased odds of peptic ulcer disease compared to those who have never used them, a cross-sectional study found. http://ms.spr.ly/6185tDE5N

29/10/2025

Get out there!

23/10/2025

It might not be the gluten. But its so commonly villanised!

The findings of a landmark study have revealed that gluten sensitivity, which affects approximately 10% of the global population, is not actually about gluten but part of the way the gut and brain interact.

In the largest combined analysis, only a few tightly controlled trials found any real gluten reaction. Overall, people’s responses were no different from when they were given a placebo. This study is expected to set a new benchmark for how gluten sensitivity is defined, diagnosed and treated.

Tap through to read more → unimelb.me/3L3jDaQ

16/10/2025

Are you taking collagen, hoping it will result in improvements in wrinkles, skin elasticity and hydration? A recent analysis of the research showed that these effects were only significant among studies which had been funded by pharmaceutical companies.
My tip in the comments

Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.