Medical Technologist, Clinical Lab Scientist

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MTCLS Bilal Masood IIMCT RIUπŸŽ“πŸ‘¨πŸ»β€πŸ”¬
Clinical Lab Scientist at IDC Head Office
Former Deputy Manager HWL Head Office
Former Lab Technologist at QIH Isb
Former Lab Incharge at PMDH Rwp
Researcher at IIMCT GRH Rwp

Identify the CellsπŸŸ£β­•??(1) Proerythroblast (2) Myeloblast (3) Lower region of image shows a promyelocyte. (4) Toward th...
28/09/2025

Identify the CellsπŸŸ£β­•??
(1) Proerythroblast
(2) Myeloblast
(3) Lower region of image shows a promyelocyte.
(4) Toward the upper left are a metamyelocyte and
(5) A segmented neutrophilic granulocyte.

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MTCLS Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Identify the CellsπŸŸ£β­•:Early erythropoiesis (development of red blood cells) with the following cells identified:(1) Proer...
27/09/2025

Identify the CellsπŸŸ£β­•:
Early erythropoiesis (development of red blood cells) with the following cells identified:
(1) Proerythroblast: The largest cell, with dark blue cytoplasm and loosely arranged nuclear chromatin. This is the *earliest recognizable red cell precursor.
(2) Orthochromatic erythroblasts: Two smaller cells below the proerythroblast, likely maturing towards becoming reticulocytes.
(3) Metamyelocyte: A cell from the granulocyte lineage (part of white blood cell development), not part of erythropoiesis.

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MTCLS Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

A supravital stained Hemoglobin H Disease. Hemoglobin H inclusions are seen in the red blood cells. Blood smear showing ...
26/09/2025

A supravital stained Hemoglobin H Disease. Hemoglobin H inclusions are seen in the red blood cells.

Blood smear showing marked poikilocytosis (tearsdrop cells, schistocytes, target cells, and elliptocytes).
[Check Previous Post For HBH Peripheral Smear]

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MTCLS Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Peripheral Blood Smear Of Hemoglobin H Disease Patient reveals marked poikilocytosis (tearsdrop cells, schistocytes, tar...
26/09/2025

Peripheral Blood Smear Of Hemoglobin H Disease Patient reveals marked poikilocytosis (tearsdrop cells, schistocytes, target cells, and elliptocytes).
Check Next Post For Haemoglobin H Inclusion in Supravital Stain (Brilliant Cresyl Blue)🫟

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MTCLS Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

- Abnormal promyelocytes: 77% [Next Post]- Metamyelocytes: 10%- Myelocytes: 3%- Promyelocytes: 6%Peripheral blood smear ...
23/09/2025

- Abnormal promyelocytes: 77% [Next Post]
- Metamyelocytes: 10%
- Myelocytes: 3%
- Promyelocytes: 6%

Peripheral blood smear Shows different stages of granulocyte development, highlighting a predominance of abnormal promyelocytes (77.0%). This is consistent with Acute Promyelocytic Leukemia (APL), a subtype of Acute Myeloid Leukemia (AML-M3).

Abnormal promyelocytes are predominant*: This is typical in APL, where these cells accumulate in the bone marrow and peripheral blood.

Presence of t(15;17) translocation* (not shown in the image but characteristic of APL) leads to the accumulation of these abnormal cells.

The high percentage of abnormal promyelocytes supports the diagnosis of APL.

Do you want to know more about the diagnosis, treatment protocols, or complications of APL?

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Acute Promyelocytic Leukemia (AML-M3):Mindray MorphologyπŸŸ£β­•:A peripheral blood smear Of APL Patient.*APL (Acute Promyeloc...
23/09/2025

Acute Promyelocytic Leukemia (AML-M3):
Mindray MorphologyπŸŸ£β­•:
A peripheral blood smear Of APL Patient.
*APL (Acute Promyelocytic Leukemia):*
- A subtype of Acute Myeloid Leukemia (AML)
- Characterized by abnormal promyelocytes
- Often associated with a specific genetic abnormality: t(15;17) translocation

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Reactive Mesothelial Cells (Fluid Examination)- Have *pale blue cytoplasm* and *indeterminate cell borders* in clusters....
21/09/2025

Reactive Mesothelial Cells (Fluid Examination)
- Have *pale blue cytoplasm* and *indeterminate cell borders* in clusters.
- Found due to *trauma, metastatic tumor, or infection* in a body cavity.

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

The peripheral smear Of Chronic Lymphocytic Leukemia (CLL with smudge cells).Peripheral Smear shows a predominance of ma...
20/09/2025

The peripheral smear Of Chronic Lymphocytic Leukemia (CLL with smudge cells).
Peripheral Smear shows a predominance of mature lymphocytes alongside characteristic smudge cells. Mature lymphocytes are small to medium-sized with scant cytoplasm, round nuclei, and densely clumped chromatin. Smudge cells are fragile lymphocytes that break apart during smear preparation, appearing as amorphous, pale blue-gray material with frayed edges and a "smeared" appearance. The presence of these cells is a hallmark feature of CLL and supports the diagnosis.

Morphology: Mindray TLA

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Grey Platelet Syndrome (GPS)πŸŸ£β­•πŸ”Ή:It's a rare genetic disorder caused by the absence of alpha granules in platelets. These...
19/09/2025

Grey Platelet Syndrome (GPS)πŸŸ£β­•πŸ”Ή:
It's a rare genetic disorder caused by the absence of alpha granules in platelets. These granules store key proteins for clotting and tissue repair.

Alpha Granule Contents: Alpha granules contain coagulation factors (fibrinogen, V-factor, VIII factor), adhesive proteins (fibronectin, thrombospondin, platelet vWF), growth factors (PDGF, VEGF, TGF-Ξ²), and antimicrobial proteins. Plasma vWF is normal, but platelet vWF is lacking.

Clinical Features: Symptoms include mild to moderate bleeding (bruises, epistaxis, menorrhagia), large "gray" platelets on microscopy, and possible progressive myelofibrosis.

DiagnosisπŸ₯ΌπŸ‘¨πŸ»β€πŸ”¬πŸ”­:
- Hemogram: mild thrombocytopenia
- Platelet smear: enlarged platelets with no visible granules
- Electron microscopy: absence of alpha granules
- Immunohistochemistry: absence of markers like CD62P (P-selectin)
- Genetic studies: mutations in the NBEAL2 gene.

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Bone marrow morphology of a multiple myeloma patient shows plasma cells, highlighted by arrows (>) in Figures A and B. (...
19/09/2025

Bone marrow morphology of a multiple myeloma patient shows plasma cells, highlighted by arrows (>) in Figures A and B. (Field Stain🫟) while the second picture uses a weak stain, providing a clear view of the plasma cells and making the distinction between cytoplasm and nucleus very clear.

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

Mantle Cell Lymphoma (MCL)🫟🟣:MCL is a type of non-Hodgkin Lymphoma. Morphology On Mindray TLA.MCL (Mantle Cell Lymphoma)...
19/09/2025

Mantle Cell Lymphoma (MCL)🫟🟣:
MCL is a type of non-Hodgkin Lymphoma.
Morphology On Mindray TLA.

MCL (Mantle Cell Lymphoma) and HCL (Hairy Cell Leukemia) are both lymphoproliferative disorders, but they have distinct differences:

*Cell Morphology:*
- *MCL:* Small to medium-sized lymphocytes with irregular nuclei.
- *HCL:* Hairy cells with "hair-like" projections.

*Immunophenotype:*
- *MCL:* CD5+, CD20+, Cyclin D1+.
- *HCL:* CD20+, CD103+, Annexin A1+.

*Clinical Features:*
- *MCL:* Often presents with lymphadenopathy and advanced disease.
- *HCL:* Typically involves the spleen and bone marrow.

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MTCLS: Bilal Masood πŸ’œπŸ‘¨πŸ»β€πŸ”¬
Medical Technologist, Clinical Lab Scientist

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SECTOR H-13
Islamabad
SCIENTIST

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+923045880396

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