
21/08/2025
A new study suggests that cycling can help restore neural connections damaged by Parkinsonโs disease.
Parkinsonโs affects more than 10 million people worldwide, disrupting the central nervous system and impairing movement. While exercise has long been recommended for symptom relief, this study provides direct evidence that cycling can rewire brain activity.
Researchers at University Hospitals Cleveland Medical Center recruited nine patients with Parkinsonโs who had deep brain stimulation (DBS) devices implanted. Over four weeks, participants completed 12 adaptive cycling sessions, where resistance adjusted automatically to their effort. Using the DBS devices, scientists recorded neural signals before and after the intervention.
Remarkably, the team observed measurable changes in brain signals related to motor control and movement. This demonstrated that consistent cycling promoted neuroplasticityโthe brainโs ability to reorganize and form new connections. Importantly, benefits were only seen with persistent, repeated exercise, suggesting long-term commitment is key.
Experts note that while cycling showed promise, the findings may extend to other physical activities. โIf there were a pill that worked as well as exercise for Parkinsonโs, it would be a billion-dollar pill,โ said Dr. Daniel Daneshvar of Harvard Medical School, emphasizing that exercise remains the most effective therapy.
The study also highlighted that improvements were gradual, reinforcing the need for patients to maintain regular physical activity with long-term goals rather than expecting immediate results. Future research will explore whether other exercise forms, or therapies like music or light stimulation, can provide similar brain benefits.
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RESEARCH PAPER ๐
Prajakta Joshi et al, "Electrophysiological correlates of dynamic cycling in Parkinsonโs disease.", Clinical Neurophysiology (2025)