07/04/2025
๐๐๐๐๐๐๐๐ ๐
๐๐๐๐๐๐:
The blood clotting process involves 13 factors, each with a specific role in coagulation. These are:
๐. ๐
๐๐๐ญ๐จ๐ซ ๐ - ๐
๐ข๐๐ซ๐ข๐ง๐จ๐ ๐๐ง
A glycoprotein in the blood plasma that is converted to fibrin by thrombin during blood clotting.
๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐ - ๐๐ซ๐จ๐ญ๐ก๐ซ๐จ๐ฆ๐๐ข๐ง
A precursor to thrombin, essential for clot formation.
๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐๐ - ๐๐ก๐ซ๐จ๐ฆ๐๐จ๐ฉ๐ฅ๐๐ฌ๐ญ๐ข๐ง
(Tissue Factor)
A protein that activates the extrinsic pathway of coagulation.
๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐ - ๐๐๐ฅ๐๐ข๐ฎ๐ฆ (๐๐๐+)
Essential for various enzymatic reactions in the clotting cascade.
๐. ๐
๐๐๐ญ๐จ๐ซ ๐ - ๐๐๐๐ข๐ฅ๐ ๐
๐๐๐ญ๐จ๐ซ (Proaccelerin)
Works with Factor X to activate prothrombin.
๐ฒ. ๐๐ฎ๐ฐ๐๐ผ๐ฟ ๐ฉ๐๐ - ๐ฆ๐๐ฎ๐ฏ๐น๐ฒ ๐๐ฎ๐ฐ๐๐ผ๐ฟ (Proconvertin)
(A key protein in the extrinsic clotting pathway)
๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐๐๐ - ๐๐ง๐ญ๐ข-๐ก๐๐ฆ๐จ๐ฉ๐ก๐ข๐ฅ๐ข๐ ๐
๐๐๐ญ๐จ๐ซ ๐
Deficiency leads to Hemophilia A.
๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐ - ๐๐ก๐ซ๐ข๐ฌ๐ญ๐ฆ๐๐ฌ ๐
๐๐๐ญ๐จ๐ซ (Anti-hemophilic Factor B)
Deficiency leads to Hemophilia B.
๐. ๐
๐๐๐ญ๐จ๐ซ ๐ - ๐๐ญ๐ฎ๐๐ซ๐ญ-๐๐ซ๐จ๐ฐ๐๐ซ ๐
๐๐๐ญ๐จ๐ซ
Activates thrombin, crucial for clot formation.
๐๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐ - ๐๐ฅ๐๐ฌ๐ฆ๐ ๐๐ก๐ซ๐จ๐ฆ๐๐จ๐ฉ๐ฅ๐๐ฌ๐ญ๐ข๐ง ๐๐ง๐ญ๐๐๐๐๐๐ง๐ญ
Deficiency leads to Hemophilia C.
๐๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐๐ - ๐๐๐ ๐๐ฆ๐๐ง ๐
๐๐๐ญ๐จ๐ซ
Activates the intrinsic pathway, playing a role in inflammation.
๐๐. ๐
๐๐๐ญ๐จ๐ซ ๐๐๐๐ - ๐
๐ข๐๐ซ๐ข๐ง-๐๐ญ๐๐๐ข๐ฅ๐ข๐ณ๐ข๐ง๐ ๐
๐๐๐ญ๐จ๐ซ
Strengthens and stabilizes the fibrin clot.
๐นMnemonic to Remember Clotting Factors
๐นThe mnemonic in the image helps in memorizing the factors:
๐น"Foolish People Try Climbing Long Slopes After Christmas, Some People Have Fallen."
๐กFโ Fibrinogen
๐กP โProthrombin
๐กTโ Thromboplastin
๐กC โCalcium
๐กL โLabile Factor
๐กS โStable Factor
๐กA โAnti-hemophilic Factor A
๐กC โChristmas Factor
๐กS โStuart-Prower Factor
๐กP โ Plasma Thromboplastin Antecedent
๐กH โ Hageman Factor
Formation of Blood Clots (Hemostasis)
๐ต๐. ๐๐๐ฆ๐๐ ๐๐ ๐๐ฅ๐จ๐จ๐ ๐๐๐ฌ๐ฌ๐๐ฅ ๐๐๐ฅ๐ฅ
Blood vessel injury leads to the activation of platelets.
Platelets adhere to the damaged site and release clotting factors.
๐ต๐. ๐๐๐ฉ๐๐ข๐ซ๐๐ ๐๐๐ฌ๐ฌ๐๐ฅ ๐๐๐ฅ๐ฅ
The fibrin network strengthens the clot.
Eventually, the clot is dissolved once healing is complete.
๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐๐๐ฅ๐๐ฏ๐๐ง๐๐:
โซHemophilia: Deficiency of Factor VIII (Hemophilia A) or Factor IX (Hemophilia B).
โซVitamin K Deficiency: Affects Factors II, VII, IX, and X, leading to prolonged bleeding.
โซThrombosis: Excessive clotting can lead to deep vein thrombosis (DVT) or stroke.