11/01/2026
Updated Primaquine Dosing Regimen:
To enhance compliance and efficacy in preventing relapses, the current recommendation for the antirelapse regimen is:
👉🏽• Dosage: 0.5 mg/kg body weight.
👉🏽• Duration: 7 days.
👉🏽• Administration: To be administered concurrently with standard blood-stage antimalarial therapy.
Key Clinical Considerations:
✨• G6PD Screening: It is mandatory to screen patients for Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency prior to initiating Primaquine. Patients with severe deficiency are at high risk for drug-induced hemolytic anemia.
✨• Patient Compliance: The transition from a 14-day to a 7-day high-dose regimen is primarily designed to improve treatment adherence while maintaining therapeutic efficacy.
✨• Adverse Effects: Counsel patients to take medication with food to minimize gastrointestinal distress, and to monitor for signs of dark urine or jaundice (hemolysis).