20/10/2025
A middle-aged male was evaluated for chronic loose motions. He was reportedly diagnosed with celiac disease 11 years ago based on mildly elevated TTG IgG, with negative TTG IgA, and normal duodenal biopsy. Serum IgA was not checked at that time. Despite the absence of strong diagnostic evidence, he was kept on a gluten-free diet (GFD) for the past 11 years with reportedly good compliance.
Over the years, he experienced intermittent loose motions during summer, typically lasting a few months, with abdominal cramps relieved by defecation and mucus in stool, but no weight loss or failure to thrive.
On current evaluation:
Serum IgA: Normal
TTG IgA: Normal
No nutritional deficiencies or systemic features of celiac disease.
Given these findings, celiac disease seems unlikely, and the prior diagnosis was likely erroneous.
He was restarted on a gluten-containing diet. An EGD with duodenal biopsies is planned after 4 weeks to assess for any histological changes following gluten reintroduction.
Currently, his symptoms are more in keeping with irritable bowel syndrome (IBS) – diarrhea-predominant type (IBS-D), particularly given:
Crampy abdominal pain relieved by defecation
Change in stool consistency and caliber
Mucus in stool
Association with mood issues
No weight loss or malabsorptive features
He has been counseled about the possible misdiagnosis, reassured regarding gluten intake, and provided supportive management for IBS.
Plan:
1. Continue gluten-containing diet for 4 weeks.
2. EGD + duodenal biopsy to reassess mucosa.
3. IBS management: dietary modification (low FODMAP if needed), stress reduction, symptomatic relief.
4. Follow-up via phone for symptom monitoring.
Impression:
Likely Irritable Bowel Syndrome (IBS-D); prior false diagnosis of celiac disease.