Dr Tanweer Ahmed Dayo

!!!!!Nervous System"""" Wellcome back after Some time,,,,,,

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Allah jo karta he woh behtar hee hota he

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Angiotensin II Causes Biphasic STAT3 Activation Through TLR4 to Initiate Cardiac Remodeling
---ABSTRACT---
Evidence indicates that Ang II (angiotensin II) activates STAT3 (signal transducer and activator of transcription 3) in cardiomyocytes. However, the mechanisms underlying STAT3 activation and downstream responses are not fully known. In this study, we show that Ang II caused biphasic STAT3 activation in cardiomyocytes. A rapid and early activation was mediated by direct association between TLR4 (toll-like receptor-4) and STAT3. This early activation increased IL-6 (interleukin-6) production, which in turn, induced the second STAT3 activation through the IL-6/gp130 (glycoprotein 130)/JAK2 (Janus-family tyrosine kinases 2) pathway, resulting in unregulated expression of genes for cardiac remodeling. Moreover, STAT3 inhibition or TLR4 knockout in mice protected against Ang II–induced hypertrophy, fibrosis, and cardiac functional deficits. Thus, Ang II–induced STAT3 activation in cardiomyocytes was biphasic, providing a sequential induction of IL-6 and myocardial remodeling genes, respectively. This work supports a novel mechanism on STAT3 activation in Ang II–induced cardiac dysfunction and remodeling.
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http://spr.ly/6182D7EMM

فداک یا حبیبی یا رسول اللہ❤️
صلی اللہ علیہ وآلہ وبارک وسلم کثیرا❤️

سچے دل سے گواہی، کامیابی کی ضمانت

⬆⬆ اوپر انگوٹھے کے نشان کو بھی دبا دیجیے (y)
الله عزوجل آپکو یہ شیئر کرنے کی توفیق عطا فرماے آمین

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Remember:
Antibiotics do not treat viral infections, like colds and flu

Antibiotics are precious: ONLY take them when prescribed by a doctor!

Wo bachpan mein kehte they larai larai maff karo ALLAH ka ghar saff karo ab samjh ai ke ALLAH ka ghar to DIL Hai aur mein sari zindgi masjid samjhta raha...
💙

Bharosa to apni saanso ka bhi nahi hai or ham insaano py kar beth'ty hain....
💚

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Quran Lesson - Surah Al-Kahf 18, Verse 27, Part 15
What is the Holy Quran & How to Recite it? https://goo.gl/K9Vq16

وَاتْلُ مَا أُوحِيَ إِلَيْكَ مِنْ كِتَابِ رَبِّكَ ۖ لَا مُبَدِّلَ لِكَلِمَاتِهِ وَلَنْ تَجِدَ مِنْ دُونِهِ مُلْتَحَدًا

And recite what has been revealed to you (O Muhammad ﷺ) of the Book (the Quran) of your Lord (i.e. recite it, understand and follow its teachings and act on its orders and preach it to men). None can change His Words, and none will you find as a refuge other than Him.

اے نبی! جو کچھ آپ کی طرف وحی کیا گیا ہے آپ کے اپنے پروردگار کی کتاب میں سے وہ انھیں پڑھ کر سنا دو۔ کوئی اس کے ارشادات کو بدلنے کا مجاز نہیں (اور اگر کوئی ایسا کام کرے تو) آپ اللہ کے سوا اس کے لئے کوئی پناہ کی جگہ نہ پائیں گے۔

[Al-Quran 18: 27]

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