Cyclical Fasting

31/05/2022

The older you are the more attention to muscle building

This video clip is from Ask Me Anything Episode #32, originally released on February 21, 2022. Listen to the full episode & read show notes here: https://bit...

14/01/2022

A key regulator of the process of autophagy is a drop in cellular levels of acetyl CoA, an end product of nutrient metabolism. As one would expect, fasting –...

12/01/2022

Alternate-day fasting less effectively reduces body fat mass than a matched degree of daily energy restriction and without evidence of fasting-specific effects on metabolic regulation or cardiovascular health.


https://pubmed.ncbi.nlm.nih.gov/34135111/

Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healthy individuals (0:150; n = 12). Control gro...

15/12/2021

https://youtu.be/dmDsFU6WMR4

Scientists have been studying the effect on the body's metabolism of fasting, and how it may play into aging. In this web exclusive, "Sunday Morning" corresp...

06/12/2021

Good to know

https://youtu.be/zC9_g01disc

Intermittent fasting really took off after mice data reported reductions in body weight, blood sugar levels, inflammation, and increased lifespan when follow...

08/11/2021

Fasting from dawn to sunset for 30 days increased levels of proteins that play a crucial role in improving insulin resistance and protecting against the risks from a high-fat, high-sugar diet, according to researchers.

05/11/2021

This article was written for doctors whose patients are doing intermittent fasting. But it's also a good introduction to the topic which shows how much the mainstream medical establishment has come around to seeing the value and benefits of both intermittent and prolonged fasts in the past few years.
Even five years ago, many medical websites were sounding alarms about how "unsafe" fasting was. This has largely been reversed.
From the article (emphases are mine):
"Excluding specific conditions, fasting is exceedingly safe. It has been practiced worldwide for millennia and is a facet of every major religious culture, including Judaism, Christianity, Islam, Hinduism, and Buddhism.
Anecdotally, concern has been expressed about the effect of entering “starvation mode,” a catabolic state in which the body ceases basal metabolic function, turning to muscle protein as a source of fuel. This, however, is physiologically inaccurate with intermittent fasts (for definition, see tables below).
The opposite occurs: basal metabolic rate increases during a fasted state, and is accompanied by increases in serum levels of norepinephrine (noradrenaline) and growth hormone...
Both intermittent fasting and time-restricted feeding (see below) have demonstrated efficacy in reducing weight, central adiposity, and HbA1c in clinical trials ranging from 8 to 52 weeks.
There is also evidence that intermittent fasting and time-restricted feeding improve insulin sensitivity as well as biomarkers relating to cardiovascular disease such as blood pressure and resting heart rate.
A therapeutic fasting regimen in patients with type 2 diabetes is also a known strategy for de-prescription and inducing disease remission.
Ongoing research is exploring the relationship between periods of fasting and improved immune function, increased longevity, treatment for chronic neurological disorders, enhanced cognitive performance, and more...

https://diabetes.medicinematters.com/diet/type-2-diabetes/intermittent-fasting-type-2-diabetes/17226834?fbclid=IwAR1mdtwL-xSnWFL3BSTwnz4t93UqxYksBy9uGab7kE09hDtD_ZwMO9dvHhA

Is this increasingly popular weight management tactic an option for your patients with type 2 diabetes? Primary care physician Jay Shubrook and Jamie Katuna explain in this illustrative case study.

01/11/2021

Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases
(Sept 2021) https://doi.org/10.3390/ph14100982
Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits, vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic acid, and ellagitannin. Some well-known polyphenols include resveratrol, quercetin, curcumin, epigallocatechin gallate, catechin, hesperetin, cyanidin, procyanidin, caffeic acid, and genistein. They can modulate different pathways inside the host, thereby inducing various health benefits. Autophagy is a conserved process that maintains cellular homeostasis by clearing the damaged cellular components and balancing cellular survival and overall health. Polyphenols could maintain autophagic equilibrium, thereby providing various health benefits in mediating neuroprotection and exhibiting anticancer and antidiabetic properties. They could limit brain damage by dismantling misfolded proteins and dysfunctional mitochondria, thereby activating autophagy and eliciting neuroprotection. An anticarcinogenic mechanism is stimulated by modulating canonical and non-canonical signalling pathways. Polyphenols could also decrease insulin resistance and inhibit loss of pancreatic islet β-cell mass and function from inducing antidiabetic activity. Polyphenols are usually included in the diet and may not cause significant side effects that could be effectively used to prevent and treat major diseases and ailments.

Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits, vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic acid, and ellagitannin. Some well-known polyphenols include resveratrol, quercetin, curcumin, epigallocatechin g...

01/11/2021

Resveratrol is well know polyphenol

01/11/2021

Take polyphenols during your meal break. It will improve the effects of autophagy



https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7285205/

It has been thought that caloric restriction favors longevity and healthy aging where autophagy plays a vital role. However, autophagy decreases during aging and that can lead to the development of aging-associated diseases such as cancer, diabetes, neurodegeneration, ...

30/10/2021

Rapamycin blocks the activity of the mTOR gene

Fisetin is an active senoliic.

Their effects can be combined.

Rapamacin is taken once, on the first day of the restriction days. Fisetin is taken daily at 400 mg

29/10/2021

Caffeine – especially when consumed early in the morning – resets the body's internal clocks and provides a mental boost that helps us start the day. But how...

25/10/2021

How does the 5/2 diet work? Very simple!

During work days, you limit your food (calorie) intake by using intermittent fasting (time-restricted feeding protocols). You can walk, run or use any other type of aerobic exercise during these days. You can also rest and do nothing.

On weekends, you have full meals. On these days, you need to go to the gym and do strength exercises.

That's it. Simple, but very powerfull!

22/10/2021

Intermittent fasting is a trendy weight loss strategy. A new study of fasting fruit flies shows how the diet, if properly timed, also slows the aging process and increases longevity by cleaning our cells.

15/10/2021

Scientists continue to explore the connection between fasting and the consequences for human health, both good and bad, and part of this research includes diets that merely mimic its effects. A new study has shown how short spurts of these so-called fasting-mimicking diets can bring about a range…

14/10/2021

https://youtu.be/dhjZcFbKFdM

In this episode, Dr. Mark Mattson discusses how stressing the body through exercise, fasting, and plant phytochemicals have beneficial effects on the brain a...

03/08/2021

How does cyclical fasting combat the loss of muscle mass and prevent infirmity and sarcopenia?
1 .The program includes days of normal nutrition during which exercises are performed that stimulate muscle growth. Please check the Carb Cycling Diet regimes:
https://www.facebook.com/carbcyclingdiet
2. During the food break, sports supplements are taken that protect the muscles from destruction

03/08/2021

7 benefits of Cyclical fasting:
1. Many regimes (based on Carb Cycling Diet regimes)
2. Minimum hunger
3. Preservation of muscle mass
4. Elimination of senescent cells
5. Elimination of lipofuscin
6. А more active autophagy process
7. Marked improvement of insulin resistance