30/01/2026
The human fetal environment was previously thought to be predominantly suppressive and incompatible for T effector maturation.
Researchers from SingHealth Duke-NUS Translational Immunology Institute (TII), KK Women's and Children's Hospital and Duke-NUS Medical School employed a high parametric, mass cytometryโbased approach to study the fetal circulatory and tissue immunomes.
Their findings provided evidence of a fetal regulatory environment that is permissive for T effector maturation, in part contributed by the relative instability and hypofunctionality in fetal Tregs.
Read more about human fetal immunology and inflammation, PNAS: http://bit.ly/3Wvfuyw
AMC researchers involved: Jing Yao Leong, Martin Wasser, Pavanish K*mar, Shi Huan Tay, Sharifah Nur Hazirah, Joo Guan Yeo, Xiu Qi Tan, Nursyuhadah Sutamam, Farah Nadiah Azman, Camillus Jian Hui Chua, Phyllis ZiXuan Chen, Fauziah Ally, Lakshmi Ramakrishna, Su Li Poh, Liang Xie, Yiping Fan, Thaschawee Arkachaisri, Jerry Kok Yen Chan, Florent Ginhoux, Salvatore Albani
Collaborators: Naomi McGovern, Archita Mishra (Agency for Science, Technology and Research (A*STAR)), Charles-Antoine Dutertre (Gustave Roussy Cancer Campus), David Vermijlenl, Catherine Donner, Maria Papadopoulou (ULB - Universitรฉ libre de Bruxelles)
VisAcademic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research