08/07/2025
[New knowledge sharing from the 2025 Chronic Kidney Disease Nutrition Care and Pharmacy Market Trends Seminar~]
probiotics have the potential to delay kidney disease TYCA06 BLI-02 VDD088
I was very happy to be invited by Huaxin International Pharmaceuticals a while ago to participate in the "2025 Chronic Kidney Disease Nutrition Care and Pharmacy Market Trends Seminar" hosted by the Chinese Store Management and Development Association. I took classes with many pharmacists. The seminar course invited Dr. Cai Xinyu, who specializes in probiotics, to share the precise nutritional control of chronic kidney disease and the current status of kidney probiotic applications. I felt that I benefited a lot after the class!
When I was still in the National Taiwan University Hospital, I was responsible for a chronic kidney disease health education clinic every week. I came into contact with countless chronic kidney disease patients. In order to take better care of kidney patients, I also obtained the qualification of a kidney specialist nutritionist.
After several years of outpatient experience, I know that kidney patients have many troubles in life and diet, including what to eat and what not to eat, blood potassium and blood phosphorus control, etc. As the saying goes, "long illness makes a good doctor." Kidney patients need sufficient professional knowledge to take good care of themselves, but there is a lot of wrong information on the Internet. As a professional, I think it is very important to convey correct knowledge to kidney patients. Therefore, when I received the invitation to this seminar, I was naturally eager to learn new knowledge~
According to a large-scale study published in 2016, the global prevalence of chronic kidney disease is about 13.4%. Kidney disease can be divided into stages 1-5, with stage 1 being the mildest and stage 5 being the most severe. The global prevalence of stage 3-5 chronic kidney disease is about 10.6%. Let's look at the situation in our country. According to the data of the Taiwan Nephrology Society, one in eight adults in Taiwan has kidney disease, and the prevalence of chronic kidney disease in adults over 20 years old has exceeded 12%.
Many people think that once kidney disease is confirmed, dialysis must be performed. This is very wrong information, because kidney disease is divided into 5 stages, and the last stage is the stage of dialysis preparation and dialysis. Therefore, for the care of patients who have not yet undergone dialysis, policies such as low-protein diet and reducing the production of renal toxins are all aimed at delaying the course of kidney disease.
Studies have found that the richness and diversity of intestinal bacteria in patients with kidney disease are significantly lower than those in healthy people; dialysis patients also have fewer beneficial intestinal bacteria than healthy people, so the idea of applying probiotics to patients with chronic kidney disease has begun to emerge. A study in 2018 proposed the gut-kidney axis hypothesis:
1. Metabolic pathway: nutritional imbalance > intestinal bacterial imbalance > toxic substances produced after metabolism > damage to the intestinal barrier > increased endotoxins and nephrotoxins > attack on the kidneys
2. Immune pathway: intestinal bacterial imbalance > increased immune response and cytokines > promotion of kidney inflammatory substances > attack on the kidneys
If the good bacteria in the intestine can be increased and some kidney-protecting metabolites can be produced, kidney damage may be delayed.
During the seminar, Dr. Cai proposed three strains with such potential:
1. Bifidobacterium longum BLI-02: has high antioxidant capacity, is not easy to produce indole nephrotoxin, inhibits a variety of pathogens, and reduces infections caused by weak resistance.
2. Lactobacillus acidophilus TYCA06: has good acid production ability, is not easy to produce indole nephrotoxin, has the function of regulating intestinal flora, and can improve the inflammatory response of chronic kidney disease.
3. Bifidobacterium bifidum VDD088: has high intestinal adsorption capacity. Studies have found that patients with stage 3 kidney disease can delay the deterioration of renal function by taking it for 3-6 months, and improve the side effects of long-term medication.
Probiotics have been really popular in recent years, but because there are many strains, each with different functions, if you want to take probiotics, I always recommend doing your homework first. The probiotic strain combination of this seminar has also applied for patents and conducted many clinical studies, so before choosing, you should pay attention to the strains, whether the formula is low in sodium, phosphorus and potassium, check whether there are any clinical studies, etc., and you can also ask your attending physician whether it is suitable, instead of just buying it because the advertisement is attractive and the price is cheap.
Even these strains can only delay the course of kidney disease, not treat it! But even if they can delay the process, it is already amazing to me! So I will share what I have learned with flour~