Peregrine WORx, Atlanta, GA (2025)

04/30/2025

What's an easy task you accomplish before beginning your day? One which can domino into completing more and more.

Eating breakfast?
Shaving?
Walking the dog?

I bet most of you don't make your bed before hopping over to the home office or to your clients.

Leave a comment to share with others what gets you going for the day that most people don't consider?

04/25/2025

Roche to increase its US footprint with sweeping $50B investment, furthering pharma's onshoring push.

Roche also has the newer SBX platform in the NGS space.

Roche is making moves with a $50 billion investment in U.S. manufacturing facilities, focusing on next-gen weight loss meds, glucose monitoring devices, and gene therapy.

This significant investment will create about 1,000 new jobs and expand Roche's existing U.S. footprint, emphasizing its commitment to innovation and growth in the country. The company aims to export more medicines from the U.S. than it imports, aligning with a broader trend of major drugmakers reinforcing their presence in the U.S. to support American jobs and leverage the pro-innovation policy environment.

https://zurl.co/0CHsb

03/20/2025

We have 2 open slots for the Canva Team program. This will save you money on the annual cost of $150.
Dividing the cost amongst 5 people reduces the individual cost down to $30.
All of your designs and information are kept secret and not shared with the team, unless you share it.

03/03/2025

Advanced Job Post and resume creation.

This was an early version of my Agent and in test mode. Depending on how many job posts you have loaded, it could do 5, 10, 30, or 60 resumes in a matter of minutes.

Job postings are now efficiently scraped from multiple job boards and organized into a structured spreadsheet. This allows for easy processing and analysis of large volumes of job data.

Do you know what scraping is? Python can help and there is more than one way to get this done.

Intelligent Data Processing

The scraped job information is fed into an OpenAI assistant module along with the applicant's CV and resume. This creates a powerful combination of job market data and personal qualifications.

Optimized Prompts

The key feature of this system is the carefully engineered prompt. It's designed to extract the most relevant information and create tailored resumes for each job posting.

Vector File Engineering

To ensure high-quality outputs, the vector file in the assistant has been refined to eliminate "garbage in, garbage out" scenarios. This results in more accurate and relevant resume customizations.

Automated Resume Creation

The system generates finalized resumes for each job description directly in Google Docs. This allows for easy review and editing before submission.

AI-Powered Matching

Advanced AI algorithms now compare your qualifications against job requirements, providing a more nuanced matching process.

Continuous Improvement

The field of AI-assisted job applications is rapidly evolving. New tools and techniques are constantly being developed to make the process more efficient and effective.

This advanced system (about 50% shown) streamlines the job application process, saving time and increasing the chances of landing interviews by creating highly tailored resumes for each opportunity.

**AI agents** are revolutionizing resume creation. And you can create any Agent you want.

Video and music were all completed using Canva.

02/28/2025

Are you dosing thiopurines safely?

Irritable Bowel Disease, Crohn's Disease, Ulcerative colitis, SLE, transplants, and more are treated with these medications.

A recent study for Canadian Pediatrics analyzed their population mix with the 1000 Genome Project. See first comment for reference.

For patients with TPMT and NUDT15 variants, standard dosing can lead to severe toxicity.

With increasing immigration from various countries in these regions in the Atlanta, GA area, the likelihood of adverse drug reactions will increase.

Here's what healthcare professionals need to know:

- Intermediate metabolizers (TPMT/NUDT15): Start at 20%-50% of the normal dose to avoid myelosuppression.
- Poor metabolizers: Begin with just 5%-10% of the normal dose or consider alternative therapies.
- Populations like East Asians and Sub-Saharan Africans have higher frequencies of these variants—genetic testing is critical.

Genotype-guided dosing isn’t optional—it’s essential for reducing adverse events and keeping your patients safe.

Start low, monitor closely, and adjust based on clinical response.

Are you using pharmacogenomic (PGx) testing in your practice? Let’s talk about how to integrate it seamlessly.

02/17/2025

LinkedIn is great for networking and expanding your network. Creating workflows and automations to help with the manual tasks helps with connecting and relaying information even greater!

Most people are using spreadsheets to track their contacts or progress through a project.

Many don't track their progress and rely on their memory or use time to search for a conversation with a contact.

That's the old way.

The new way?
New contacts are imported into your CRM automatically when they accept the invite.
Search for contacts based on their interests - and create customized fields in your CRM.
If their email is not found, create an "easy button"* to search for their email address.
*creating the code may not be easy for you, but LLMs can help you.*
Create a task to follow up. Following up makes all the difference.

The workflow picture below shows every connection accepting my requests lately. When they accept the invitation, they are automatically removed from the messaging campaign. Then I can continue the networking and conversations through email, text, social media, and wherever they prefer. It's omnichannel.

Delete connection requests for than 45 days out - this is part of the maintenance on your account. Yes, there's a Python code for this too.

Find a system that works for you and then iterate, iterate, and iterate more.

01/31/2025

Pain: What This Means for My Patients and Yours?

Pain Modulation just got a significant boost with a recent FDA approval of a new pain drug. Vertex Pharmaceuticals has a solution for you named Journavx - I misspelled this 5 times before getting it right.

Via a different mechanism which targets the NaV1.8 channel on the DRG (doral root ganglia), which has multiple receptors for pain modulation, including 5-HT, histamine, and endo/phytocannabinoids, such as anandamide and d9-THC. (**look at the second picture** - taken from a slide in my presentations for 6.5 hours of approved CE 😀)

Trevena received approval with oliceridine as a biased-agonist at the mu-opioid receptor a few years ago and its stock has not performed well since.

However, +50 million Americans live with chronic pain, impacting daily life and mental health - CDC

I've seen firsthand how current pain meds often fall short, with 15% of patients reporting difficulty in treatments - Mayo Clinic

Connections to cancer treatment: how this approval might pave the way for more effective pain management in oncology, and what this could mean for patients with cancer?

Typical treatments involve opioids that may require further metabolism for better treatment.

Cancer patients with certain genetic SNPs have an increased risk of not being adequately treated; thus increasing hospital and clinic visits. (**look at first picture** )

What does this do in the healthcare setting? This likely labels a person an ADDICT, or DRUG-SEEKER...and it's not. And to convince healthcare workers is hard otherwise.

Odds ratio is much higher in slow metabolizers for hospital visits AND to be prescribed morphine or hydromorphone.

Recall codeine --> morphine
Recall hydrocodone --> hydromorphone

All because of CYP2D6.

Potential for Reduced Side Effects: a welcome development for patients struggling with traditional pain meds.

What This Means for My Practice (and Yours)?

Improved Patient Care: better pain modulation strategies for those who need it most - a win for all of us in healthcare.

Happy Friday!

01/28/2025

Just when I thought I had the inside scoop on the latest AI breakthrough, the plot thickens!

I've been raving about Perplexity's model, but there's more to this story now with Deepseek.

As an avid tech enthusiast, I can't help but dive deeper into the controversy surrounding DeepSeek's origins.

Made in China: DeepSeek, the brainchild of Hangzhou-based startup, has sent shockwaves through the AI world. But with great power comes great scrutiny.

The Big Questions:
How did DeepSeek develop such advanced tech so quickly and cheaply?
What's the deal with their massive stockpile of Nvidia chips?
Are there hidden strings attached to this "open-source" marvel?

While Perplexity assures us that all data stays on Western servers, the AI community is buzzing with theories and concerns. DeepSeek's rapid rise has even been dubbed a "Sputnik moment" for AI, shaking up stock prices and challenging the notion that only billion-dollar investments can lead to breakthroughs.

As someone passionate about AI advancements, I'm torn between excitement and caution.

Are we witnessing a genuine leap forward in AI capabilities, or is there more to this story?

I'd love to hear your thoughts! Are you team "revolutionary breakthrough" or team "proceed with caution"? Let's keep the conversation going as we navigate this fascinating chapter in AI history.

01/28/2025

Eli Lilly made a bold move with this acquisition of a PI3Kα inhibitor, targeting breast cancer therapy and solid tumors. More options are coming available and the advances are downstream from the typical receptor tyrosine kinase inhibitors.

The PI3K protein is between the RTK and Akt, a centrally active signaling protein involved in the mTORC2 and mTORC1 pathway.

This pathway was the focus of my research on a naturally occurring chemical made by a mold, called Chaetoglobosin K, which does not inhibit PI3K.

Other therapies targeting this pathway include copanlisib, idelalisib, duvelisib, and umbralisib. However, these medications are not specific to the PI3Kα subunit of the protein.

The drug idelalisib was the first to be approved by the FDA in 2014. The only other PI3Kα inhibitor on the market is alpelisib, which was approved in 2019.

Inhibiting PI3K leads to an increase of estrogen receptor-dependent activity, therefore, fulvestrant has been approved with many of the treatments to dampen down the estrogen activation.

Why is this big?
- It's more targeted than previous therapies
- It advances beyond typical receptor tyrosine kinase inhibitors
- It could be a new weapon against aggressive cancers

https://zurl.co/AeWWD

11/21/2024

Now launched www.GetYourTerpene.com - the world's first clinical decision support tool for finding terpenes based on your medical ma*****na needs. Let's dive into the power of personalized cannabis therapy!

What Makes GetYourTerpene.com Unique?

It's not just about THC and CBD anymore.

Terpenes are the unsung heroes of cannabis medicine.

Our tool helps you find the perfect terpene profile for your specific condition.

How It Works

1. Select your medical condition
2. Get personalized terpene recommendations
3. Find strains or products that match your ideal profile

It's that simple to start optimizing your cannabis experience.

Popular Terpenes and Their Effects

**Myrcene:** The relaxation champion. Great for sleep and pain relief.

**Limonene:** Mood-boosting citrus power. Potential anxiety and depression aid.

**Pinene:** The focus enhancer. May help with memory and alertness.

Why Terpenes Matter

Terpenes work with cannabinoids to create the "entourage effect."

This means more targeted, effective relief for your specific needs.

No more guessing which strain might work - let science guide you.

Ready to Revolutionize Your Cannabis Journey?

Head to www.GetYourTerpene.com and unlock the full potential of medical ma*****na.

Tailored terpene profiles mean better results and fewer side effects.

Let's find your perfect cannabis match today!

Got questions about terpenes or our tool? Drop them below and let's chat!

11/14/2024

Pharmacogenomics: The Key to Employer Cost Savings and Lower Healthcare Costs

Ever wonder how you can slash healthcare costs without sacrificing quality? Pharmacogenomics might just be the secret weapon.

KEY TAKEAWAYS
• Pharmacogenomics can significantly reduce healthcare costs for employers
• PGx testing leads to fewer ER visits and hospital stays
• Implementing PGx programs can improve employee health outcomes
• Self-insured employers are prime candidates for PGx-driven cost savings

What's the Deal with Pharmacogenomics?
Pharmacogenomics (PGx) isn't just a fancy word - it's a game-changer for healthcare.
It's all about using genetic info to pick the right meds and doses for each person.
Think of it like a cheat code for prescribing.

Why Employers Should Care About PGx
Here's the thing: Employers are shelling out big bucks for healthcare.
PGx can help cut those costs. How?
• Fewer adverse drug reactions
• Less trial-and-error prescribing
• More effective treatments from the get-go

Real talk: It's a win-win for employers and employees.

The Numbers Don't Lie

Check this out.
A recent study showed PGx programs led to:
• 39% fewer inpatient visits
• 39% fewer ER visits
• 21% more outpatient visits (that's a good thing!)

Translation: Less money spent on expensive hospital stays and emergency care.

Self-Insured Employers, Listen Up.

If you're self-insured, PGx is your new best friend.
Why?
You've got more control over healthcare spending.
Implementing a PGx program could save you serious cash.
Plus, your employees get better care. It's a no-brainer.

How to Get Started with PGx

1. Partner with a PGx provider, that Peregrine WORx
2. Educate your employees about the benefits
3. Integrate PGx testing into your health benefits package
4. Track the results and savings over time

Pro tip: Look for providers that offer comprehensive medication management along with PGx testing.

Common PGx Misconceptions

"It's too expensive."
Nope. The long-term savings outweigh the upfront costs.

"It's not accurate enough."
Wrong again. PGx testing is highly reliable when done right.

"We don't need it for all employees."
Actually, almost everyone can benefit from PGx insights.

Tech Talk: PGx Software Solutions

Let's get real:
Managing PGx data can be a headache without the right tools.
That's where PGx software comes in.
Look for platforms that:
• Integrate with existing health records
• Provide easy-to-understand reports
• Offer ongoing support and updates

The Bottom Line

Pharmacogenomics isn't just hype.
It's a practical way to cut healthcare costs and improve outcomes.
For employers, especially self-insured ones, it's a smart move.
Ready to dive into the world of PGx?
Your wallet (and your employees) will thank you.

10/29/2024

How often are you measuring cystatin C?

Revolutionizing Kidney Health Assessment: The Evolution of eGFR Equations

A significant advancement in chronic kidney disease detection has emerged with the implementation of new estimated glomerular filtration rate (eGFR) equations. These updated formulas, which now incorporate both creatinine and cystatin C measurements, are providing healthcare professionals with a more precise tool for evaluating kidney function, particularly in pediatric and young adult populations.

This innovative approach is set to enhance early diagnosis and improve patient care across all age groups. As healthcare continues to evolve, such advancements underscore the importance of staying current with the latest diagnostic methodologies.

Peregrine WORx

04/30/2025

04/25/2025

03/20/2025

03/03/2025

02/28/2025

02/17/2025

01/31/2025

01/28/2025

01/28/2025

11/21/2024

11/14/2024

10/29/2024

Address

Telephone

Website

Alerts

Contact The Practice

Shortcuts

Share

Category