05/22/2024
Metabolic Profile and Long-Term Risk of Depression, Anxiety, and Stress-Related Disorders
Depression, anxiety, and stress-related disorders are common psychiatric disorders, affecting approximately one-third of individuals during their life course.(1) Increasing evidence suggests that metabolic dysregulation may contribute to the development of psychiatric disorders. (2-4) Inflammation may play an important role in the link between metabolic dysregulation and psychiatric disorders. Lipid and glucose abnormalities may activate innate immune cells,(5-8) to promote the release of proinflammatory cytokines and biogenic amines catabolism,(9,10) and consequently lead to microglia-induced hypothalamic inflammation,(11) which have all been linked to the development of depression, anxiety, and stress-related disorders. Furthermore, adipokines, saturated fatty acids in plasma, and gut-signal molecules might increase the permeability of the blood-brain barrier, resulting in an elevated risk of chronic inflammation in the brain and eventually a higher risk of psychiatric disorders.(12)
In this cohort study of more than 200,000 participants, high levels of glucose and triglycerides and low levels of high-density lipoprotein were associated with future risk of depression, anxiety, and stress-related disorders. These findings may support closer follow-up of individuals with metabolic dysregulation for the prevention and diagnosis of psychiatric disorders.
Results add further evidence of the association between cardio-metabolic health and psychiatric disorders and potentially advocate for a closer follow-up of individuals with metabolic dysregulations for prevention and early diagnosis of psychiatric disorders.
The upcoming seminar Embodimind: Diagnosing and Treating Cognitive Disorders follows the rule that "Brains evolved to regulate the body’s energy; it is a fact that energy regulation is a core brain function”. Cognitive distortion is not just the brain processing information and using the predictive parts of the brain. But this always comes to worry, rumination and usually, some form of addiction, whether chemical, social or quest for ‘MORE’. This seminar looks at ways to diagnose and treat conditions that affect 25 to 40% of the world’s population.
For more information and bookings click on the link below
Online Bookings
https://www.eventbrite.com.au/e/online-embodimind-diagnosing-and-treating-cognitive-distortion-tickets-900823686897?aff=ebdsoporgprofile
In Person bookings
https://www.eventbrite.com.au/e/santa-monica-embodimind-diagnosing-and-treating-cognitive-distortion-tickets-879861869537?aff=ebdsoporgprofile
Article and References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988352/ #:~:text=Findings,%2C%20and%20stress%2Drelated%20disorders.
1) The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013. Int J Epidemiol. 2014;43(2):476-493. doi:10.1093/ije/dyu038
2) Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications. Dialogues Clin Neurosci. 2018;20(1):63-73. doi:10.31887/DCNS.2018.20.1/bpenninx
3) Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care. 2012;35(5):1171-1180. doi:10.2337/dc11-2055
4) Metabolic dysregulation and late-life depression: a prospective study. Psychol Med. 2017;47(6):1041-1052. doi:10.1017/S0033291716003196
5) Inflammatory proteins and depression in the elderly. Epidemiology. 2003;14(1):103-107. doi:10.1097/00001648-200301000-00025Pub
6) Inflammatory markers in late-life depression: results from a population-based study. J Affect Disord. 2008;106(3):249-255. doi:10.1016/j.jad.2007.07.002
7) Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI study. Biol Psychiatry. 2009;65(11):973-978. doi:10.1016/j.biopsych.2008.11.011
8) Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats. Behav Brain Funct. 2014;10:30. doi:10.1186/1744-9081-10-30
9) Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology. 2010;35(13):2510-2520. doi:10.1038/npp.2010.116
10) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry. 2007;12(4):331-359. doi:10.1038/sj.mp.4001949
11) Obesity, neuroinflammation, and reproductive function. Endocrinology. 2019;160(11):2719-2736. doi:10.1210/en.2019-00487
12) Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Front Neurosci. 2018;12:930. doi:10.3389/fnins.2018.00930
looks at brain anatomy and physiology to measure the Soma/Psychic interface.
