American Journal of Physiology-Endocrinology and Metabolism

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American Journal of Physiology-Endocrinology and Metabolism

Published by the American Physiological Society, the journal features original, mechanistic studies o

The American Journal of Physiology - Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism

, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.

04/21/2026

Special thanks to and for today's , How long should washout be to reliably measure de novo lipogenesis using deuterated water?; Exploratory analysis from a randomised crossover trial (Steven Carter et al.):

https://ow.ly/GLSg50YNCPS

04/16/2026

From our Liver Metabolism collection comes today's , The evolution of steatosis and in mice on a MASH-inducing diet and the effects of housing temperature (Neil Blok et al. ):

https://ow.ly/FfFy50YKxS3

04/14/2026

Check out today's , Impact of infusing the cholesterol precursor mevalonate on the hypocholesterolemia of and its potential consequences: a response (Lauren De Bruyn et al.):

https://ow.ly/XlMx50YJ1qn

04/09/2026

An equally large and talented team from put together this paper, Effect of in utero metformin exposure in gestational mellitus on infant mesenchymal stem cell (Ericka Biagioni et al.):

https://ow.ly/WbRx50YGHqb

04/07/2026

Today's takes a closer look at treating obesity in males and females. S*x differences in exogenous glucose oxidation are attenuated by obesity: Insights from a [U-¹³C₆]glucose home breath test (Stephanie Estafanos et al. and ):

https://ow.ly/C1R150YF3jO

04/02/2026

The first of April is here! Discovery of a novel regulator, 3β-sulfate-5-cholestenoic acid, of lipid and (Yaping Wang et al. ):

https://ow.ly/p23T50YCjn3

03/26/2026

Today's is worth a review knowing how we use lipids to battle , GPR180 reduces adiposity by inhibiting lipogenesis and fatty acid uptake in (Ziming Zhu et al.):

https://ow.ly/5VUC50YzeCr

03/24/2026

Take a short break to review today's Mini-Review , Immunometabolism of IRF4 in Adipose, , and Immune Cells Influences and MASLD (Daniel Marko and Jonathan Schertzer ):

https://ow.ly/4yah50Yyghr

03/19/2026

From our Liver Metabolism collection comes today's , A novel soluble guanylate cyclase activator, avenciguat, in combination with empagliflozin, protects against renal and hepatic injury in diabetic db/db mice (Nisha Sharma et al. ):

https://ow.ly/aB3s50YwmRA

03/17/2026

Today's follows on from other great work in type 2 diabetes. Acute Interleukin-1ß antagonism decreases systemic inflammation, increases GLP-1 release and modulates secretion in individuals with prediabetes (Justus Fischer et al.):

https://ow.ly/8eNo50YvsKH

03/13/2026

Are you passionate about ?
We invite you to submit your research to 's new Call for Papers!
Help us advance the science of metabolism, energy balance, and endocrine function.
Submit today: https://ow.ly/kTiK50YtpT7

03/12/2026

Check out today's work again infections like -coli, The influence of interleukin-27 on in a murine neonatal model of bacterial sepsis (Jessica Povroznik et al. ):

https://ow.ly/mVwG50Yt2f9

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