08/03/2025
Researchers have identified a surprising link between gum disease and colon cancer. A specific type of oral bacterium, Fusobacterium nucleatum—commonly found in inflamed gums—has been detected inside colorectal cancer tumors. This bacterium is known to play a role in periodontal disease and now appears to influence cancer biology beyond the mouth.
Researchers discovered that F. nucleatum can travel from the oral cavity through the bloodstream to the colon. Once there, it invades tumor tissues and creates a microenvironment that supports cancer cell survival and immune evasion. In experimental models, its presence accelerated tumor growth and may have contributed to metastatic potential.
The exact mechanism is still under investigation, but early evidence suggests that this oral bacterium can suppress anti-tumor immune responses and promote inflammation—both of which may help tumors grow and spread more aggressively. It is found more frequently in cancerous tissue than in surrounding healthy colon tissue.
This groundbreaking research strengthens the growing understanding of the mouth–gut connection. It highlights the potential role of oral health, not just in preventing dental disease, but also in maintaining systemic health and possibly influencing cancer outcomes.
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