04/15/2026
You will see me talk about bacterial endotoxin more often than you care to read about. This is my message for almost every ailment you suffer. Get the gut and stress under control, increase the c02 retention through breath work and get the minerals in. Healthy cellular respiration and reduced bacterial load contributes to healing and continued good health
Bacteria can cause misleading thyroid test results.
Bacterial endotoxin, also called lipopolysaccharide (LPS), is a toxin produced by the outer membrane of certain bacteria. It enters the blood when those bacteria die or when endotoxin leaks across a damaged or overly permeable gut barrier.
Bacterial endotoxin lowers thyroid hormones.
Importantly, it also lowers TSH.
Many doctors see TSH as an objective test for thyroid hormones and insist that lower TSH means higher thyroid hormones—but there are a large number of common stressors that reverse the relationship between TSH and thyroid hormones.
Levothyroxine is T4—the precursor to thyroid hormone—it’s effects depend on conversion.
“Endotoxin injection was associated with decreases in T4, FT4, T3, (←thyroid hormones) and TSH and a rise in rT3, reproducing the major features of the euthyroid sick syndrome.”
Bacterial endotoxin is produced in the gut, and harmful doses enter the blood during ‘stress’, causing ‘leaky gut syndrome’.
High concentrations are also found in certain foods, supplements, and, occasionally, drugs. Inhalation of endotoxin causes asthmatic symptoms.
Ref: Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man
Some things that can help in dealing with endotoxin:
—Aged cascara sagrada can stimulate peristalsis, thereby reducing the absorption of endotoxin associated with constipation.
—Aged cascara sagrada contains compounds that alleviate inflammation caused by endotoxin.
—Antibiotics like minocycline are effective in killing bacteria and reducing the risk of endotoxin-induced complications.
—Aspirin works by inhibiting TLR4, the endotoxin receptor.
—Cocoa reduces gut permeability, commonly referred to as “leaky gut.”
—Coffee possesses protective effects on the gut barrier and can reduce circulating endotoxin levels, regardless of its caffeine content.
—Coffee, by increasing peristalsis, can reduce constipation-related endotoxemia.
—DHEA plays a protective role against endotoxin-induced inflammation by suppressing the production of TNF.
—Ginger has the ability to reduce endotoxin levels and associated inflammation.
—Glycine decreases mortality in animals dosed with endotoxin.
—High-fat diets, at least those rich in polyunsaturated fatty acids, can increase endotoxin levels in the body, at least in the short term.
—Inadequate sleep and circadian disorganization increase endotoxin.
—Naringenin, found in citrus fruits, blocks endotoxin-TLR4-related inflammation caused by endotoxin.
—Orange juice reduces gut permeability and circulating endotoxin levels.
—Pregnenolone and allopregnanolone inhibit TLR4 signalling, reducing endotoxin-induced inflammation.
—Progesterone prolongs survival in animals given high doses of endotoxin.
—Some probiotics may reduce endotoxin - promising candidates include Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, Bacillus licheniformis, Mutaflor, Biosporin, and Bacillus clausii.
—Sugar (glucose) protects against stress-induced intestinal permeability.
—Carbohydrate also supports endotoxin clearance.
—Taurine alleviates endotoxin-induced liver injury.
—Vitamin A has numerous protective effects against endotoxin.
—Vitamin B1 in the form of benfotiamine reduces endotoxic inflammation.
—Vitamin C deficiency increases circulating endotoxin.
—Vitamin D helps seal the gut and reduces inflammation caused by endotoxin.
—Vitamin E reduces endotoxin-induced asthma symptoms and general inflammation.
—Vitamin K2 and K1 can protect the testicles from endotoxin damage.
—Well-cooked mushrooms can also help to clear endotoxins from the gastrointestinal system and reduce inflammation.
—Zinc is essential for a healthy gut barrier - keeping endotoxin out of general circulation.