12/04/2021
With the myriad of products out there, over the counter CBD dosing and safety can be very confusing. We can look at a current FDA-approved CBD medication, EPIDIOLEX (cannabidiol) to guide our decision making for safe usage of CBD.
Safety: With most drugs, the more you take the higher the chance of having negative effects. Fortunately, CBD is generally well tolerated. For some people, positive effects may be seen as low as 25 mg/day, while EPIDIOLEX can be given up to 25mg/kg/day for seizures associated with TSC, LGS, and Dravet syndrome. For a 70 kg adult (154 lbs), that is up to 1,750 mg /day. At those doses, most common adverse effects include: elevated liver enzymes, diarrhea, decrased appetite, vomiting, somnolence, and pyrexia. Biggest precautions to CBD? Hypersensitivity with CBD and patients with liver problems.
So how much should I take? Clinical double-blind randomized placebo-controlled trials in healthy volunteers suggest that doses as low as 0.5mg/kg (35mg in a 70kg, 154lbs adult) can reduce anxiety when taken orally, and up to 600mg/day in most trials. This essentially covers most over the counter CBD products available.
Like most medicines, the key to get the right dosing is to slowly titrate the dosing up over a period of several weeks until the effects are felt. That way, you can maximize the effects of CBD while minimizing the side effects.
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Extra Readings:
https://www.mdpi.com/2218-273X/10/11/1575/htm