Dallas Vein Specialists

Dallas Vein Specialists Aesthetic phlebology using state-of-the-art treatments for Varicose Veins, Spider Veins and other Ve Dr. Lonnie L.
(14)

Whiddon is a vascular surgeon with more than 30 years experience. Dr. Whiddon personally provides minimally-invasive vein treatment solutions, including Sclerotherapy and Laser Vein Removal, for Varicose veins, Spider veins, Leg veins, Veins on the face, Venous ulcers and more complex venous disorders.

New featured review on search.google.comDr. Whiddon is amazing and Im so grateful I found him. He and his team are profe...
01/30/2021

New featured review on search.google.com
Dr. Whiddon is amazing and Im so grateful I found him. He and his team are professional and so nice and he cares about the results and patient satisfaction. I required extra treatments beyond the initial plan and he performed them at not additional cost, and assured me if after some more healing time I decided I needed more treatments that would be covered as well. Im so happy with my results, thank you!
https://bit.ly/2DP8UeP

01/29/2021
dallasveinspecialists.com

Dallas Vein Specialists – take appropriate precautions in this time of the viral pandemic

How We Contract the Virus
07/20/2020
How We Contract the Virus - Dallas Vein Specialists

How We Contract the Virus

AIRBORNE SOURCES A SNEEZE – releases about 30,000 droplets, traveling up to 200 miles per hour and may release as many as 200,000,000 (two hundred million) viral particles that are Read More

Vaccine Hopes and Doubts
07/20/2020
Vaccine Hopes and Doubts - Dallas Vein Specialists

Vaccine Hopes and Doubts

The genetic sequence of the COVID-19 virus (SARS COV 2) was first sequenced in laboratory in January of 2020. Since then huge efforts have been applied to progressing to a Read More

The Importance of SLEEP
07/17/2020
The Importance of SLEEP - Dallas Vein Specialists

The Importance of SLEEP

The Importance of Good Quality SLEEP In # 5 of this series of ‘COVID-19 Notes’, on Diet and lifestyle, I discussed the importance of sleep to one’s healthy immunity status. Read More

High Risk for COVID-19
07/07/2020
High Risk for COVID-19 - Dallas Vein Specialists

High Risk for COVID-19

It is well recognized that pre-existing health conditions such as diabetes and heart disease put people at higher risk of COVID-19 complications and death. Advanced age also has been established Read More

06/30/2020

COVID-19 Notes # 22

𝐇𝐢𝐠𝐡 𝐑𝐢𝐬𝐤 𝐟𝐫𝐨𝐦 𝐇𝐢𝐠𝐡 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐒𝐲𝐫𝐮𝐩 - 𝐏𝐚𝐫𝐭 𝐈𝐈 -- 𝐋𝐢𝐯𝐞𝐫 𝐃𝐚𝐦𝐚𝐠𝐞

𝐇𝐢𝐠𝐡 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐒𝐲𝐫𝐮𝐩 (𝐇𝐅𝐂𝐒) became available about 40 years ago. It was cheap, available and easily transported. Processed foodstuffs had become labeled as ‘reduced fat’, and instead of fat, food companies added sugar to make their products palatable. HFCS was and remains the easiest and cheapest additive for food companies to deliver this palatability. There is not one biochemical reaction in the human body that requires fructose, i.e. there is no need for fructose to be in our foods.

Fructose in small amounts, as found in fruit, is not a threat, but in high doses fructose is damaging to the body, especially the liver. Dr. Robert Lustig of UCSF, a pediatric neuroendocrinologist has been sounding the alarm for years about the dangers of consuming fructose in high amounts, think HFCS. He has written and talked extensively of the damage we are doing to ourselves and our children by our increasing consumption of HFCS. He believes that fructose is as bad as alcohol in causing the liver to store fat resulting in 𝐟𝐚𝐭𝐭𝐲 𝐥𝐢𝐯𝐞𝐫 𝐝𝐢𝐬𝐞𝐚𝐬𝐞, now alarmingly being increasingly seen in young children, and thus has detrimental effects beyond its calories in ways similar to ethanol (grain alcohol). Lustig has said, “Indeed, the only distinction is that because fructose is not metabolized in the central nervous system, it does not exert the acute neuronal depression experienced by those imbibing ethanol. These metabolic and hedonic analogies argue that fructose should be thought of as ‘alcohol without the buzz!’”

Fructose is not metabolized like glucose. As HFCS, fructose metabolites overwhelm the liver’s capacity, which drives 𝐥𝐢𝐩𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬(production of fats in the liver) and leads to 𝐡𝐞𝐩𝐚𝐭𝐢𝐜 𝐢𝐧𝐬𝐮𝐥𝐢𝐧 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞, changes which cause chronic metabolic disease. (In the development of fatty liver, 𝐡𝐞𝐩𝐚𝐭𝐢𝐜 𝐬𝐭𝐞𝐚𝐭𝐨𝐬𝐢𝐬, high fructose consumption again mimics high ethanol consumption. 𝑃𝑎𝑟𝑎𝑐𝑒𝑙𝑠𝑢𝑠: 𝑇ℎ𝑒 𝑑𝑜𝑠𝑒 𝑑𝑒𝑡𝑒𝑟𝑚𝑖𝑛𝑒𝑠 𝑡ℎ𝑒 𝑝𝑜𝑖𝑠𝑜𝑛) The vicious cycle of hepatic insulin resistance, leading to increasing insulin secretion, leading to obesity, leading to worsening insulin resistance, finally leads to inadequate insulin secretion in relation to the degree of peripheral insulin resistance and 𝒕𝒚𝒑𝒆 2 𝒅𝒊𝒂𝒃𝒆𝒕𝒆𝒔. All the while in the background fructose is driving changes in the brain’s reward system undermining satiety with increased palatability and pushing for excessive consumption.

In summary of the prior Covid-19 and this one, # 22 and # 23,

𝐇𝐅𝐂𝐒 𝐞𝐟𝐟𝐞𝐜𝐭𝐬: 𝐡𝐲𝐩𝐞𝐫𝐢𝐧𝐬𝐮𝐥𝐢𝐧𝐞𝐦𝐢𝐚

𝐨𝐱𝐢𝐝𝐚𝐭𝐢𝐯𝐞 𝐬𝐭𝐫𝐞𝐬𝐬 𝐰𝐢𝐭𝐡 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐝𝐚𝐦𝐚𝐠𝐢𝐧𝐠 𝐫𝐚𝐝𝐢𝐜𝐚𝐥𝐬 (as in Covid-19)

𝐟𝐚𝐭𝐭𝐲 𝐥𝐢𝐯𝐞𝐫 (𝐡𝐞𝐩𝐚𝐭𝐢𝐜 𝐬𝐭𝐞𝐚𝐭𝐨𝐬𝐢𝐬)

𝐢𝐧𝐬𝐮𝐥𝐢𝐧 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞(a Covid-19 comorbidity risk)

𝐩𝐚𝐧𝐜𝐫𝐞𝐚𝐭𝐢𝐜 𝐛𝐞𝐭𝐚 𝐜𝐞𝐥𝐥 𝐞𝐱𝐡𝐚𝐮𝐬𝐭𝐢𝐨𝐧 (𝐫𝐞𝐝𝐮𝐜𝐞𝐝 𝐢𝐧𝐬𝐮𝐥𝐢𝐧 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧 𝐫𝐞𝐥𝐚𝐭𝐢𝐯𝐞 𝐭𝐨 𝐧𝐞𝐞𝐝)diabetes (a Covid-19 comorbidity risk)

𝐨𝐛𝐞𝐬𝐢𝐭𝐲 (a Covid-19 comorbidity risk)

𝐞𝐥𝐞𝐯𝐚𝐭𝐞𝐝 𝐭𝐫𝐢𝐠𝐥𝐲𝐜𝐞𝐫𝐢𝐝𝐞𝐬, 𝐞𝐥𝐞𝐯𝐚𝐭𝐞𝐝 𝐋𝐃𝐋 𝐚𝐧𝐝 𝐝𝐞𝐩𝐫𝐞𝐬𝐬𝐞𝐝 𝐇𝐃𝐋 𝐜𝐡𝐨𝐥𝐞𝐬𝐭𝐞𝐫𝐨𝐥 𝐥𝐞𝐯𝐞𝐥𝐬

𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐬𝐲𝐧𝐝𝐫𝐨𝐦𝐞 (a Covid-19 comorbidity risk)

So how do we avoid 𝐇𝐅𝐂𝐒 and all its detrimental effects? The simple answer is to begin to 𝐑𝐄𝐀𝐃 𝐈𝐍𝐆𝐑𝐄𝐃𝐈𝐄𝐍𝐓𝐒 in anything we consider buying in food stores. Look for 𝐡𝐢𝐠𝐡 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐜𝐨𝐫𝐧 𝐬𝐲𝐫𝐮𝐩 (𝐇𝐅𝐂𝐒) or simply 𝐜𝐨𝐫𝐧 𝐬𝐲𝐫𝐮𝐩. Do not be tricked by big food companies and be aware that this additive may be listed under 𝐨𝐭𝐡𝐞𝐫 𝐧𝐚𝐦𝐞𝐬listed below:

𝐆𝐥𝐮𝐜𝐨𝐬𝐞-𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐆𝐥𝐮𝐜𝐨𝐬𝐞-𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐬𝐲𝐫𝐮𝐩

𝐈𝐬𝐨𝐠𝐥𝐮𝐜𝐨𝐬𝐞

𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐜𝐨𝐫𝐧 𝐬𝐲𝐫𝐮𝐩

𝐈𝐬𝐨𝐥𝐚𝐭𝐞𝐝 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐌𝐚𝐢𝐳𝐞 𝐬𝐲𝐫𝐮𝐩

𝐆𝐥𝐮𝐜𝐨𝐬𝐞/𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐬𝐲𝐫𝐮𝐩

𝐓𝐚𝐩𝐢𝐨𝐜𝐚 𝐬𝐲𝐫𝐮𝐩

𝐆𝐥𝐮𝐜𝐨𝐬𝐞 𝐬𝐲𝐫𝐮𝐩

𝐃𝐚𝐡𝐥𝐢𝐚 𝐬𝐲𝐫𝐮𝐩

𝐅𝐫𝐮𝐢𝐭 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐂𝐫𝐲𝐬𝐭𝐚𝐥𝐥𝐢𝐧𝐞 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

Do not forget to check “juice cocktails”, cereals, sodas, yogurt, salad dressings, granola/energy/nutrition bars, etc. You will be surprised by what you find.

06/29/2020

COVID-19 Notes # 22

𝐇𝐢𝐠𝐡 𝐑𝐢𝐬𝐤 𝐟𝐫𝐨𝐦 𝐇𝐢𝐠𝐡 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐒𝐲𝐫𝐮𝐩 -- 𝐏𝐚𝐫𝐭 𝐈

What would you do if you learned that an ingredient in most packaged foods and soft drinks enjoyed by both children and adults is degrading your health and making you more likely to be obese and have diabetes and in addition make you more susceptible to complications if you contract Covid-19? Well, if you are the ‘average American’ you are eating 𝟐𝟒.𝟕𝟖 𝐤𝐠 (𝟓𝟒.𝟓 𝐥𝐛𝐬) of this ingredient each year! That rate of consumption is higher than any other country in the world. And no one is speaking out about it, well, very few. I am referring to 𝑯𝑰𝑮𝑯 𝑭𝑹𝑼𝑪𝑻𝑶𝑺𝑬 𝑪𝑶𝑹𝑵 𝑺𝒀𝑹𝑼𝑷 (𝑯𝑭𝑪𝑺). America produces and consumes more of this toxic substance than any other country, and it is playing a major role in the exponential rise in obesity, prediabetes and diabetes in adults and children.

𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 is a naturally occurring substance found in many fruits and corn. When a molecule of 𝐠𝐥𝐮𝐜𝐨𝐬𝐞, derived from carbohydrates, combines with fructose, 𝐬𝐮𝐜𝐫𝐨𝐬𝐞 𝐨𝐫 𝐭𝐚𝐛𝐥𝐞 𝐬𝐮𝐠𝐚𝐫 is produced. Fructose derived from corn is made into a high concentration syrup (𝐇𝐅𝐂𝐒), which is a cheap sweetener used in the making of many foods. One only needs to read labels to see how many food items contain this sweetener. When we see how much worse this sweetener is for our bodies than either glucose or sucrose, the problem becomes obvious.

𝐇𝐅𝐂𝐒 consumption is growing exponentially, as is the increase in obesity, because fructose, a carbohydrate, has greater potential to cause obesity than either of the other 2 sugars, glucose and sucrose. Fructose in high concentrations (HFCS) complicates glucose metabolism, damages liver cells and causes changes in the lipid profile. Fructose increases insulin resistance and is now a recognized cause of pre-diabetes and diabetes. Fructose consumed in fruits does not have the impact seen with the concentrated HFCS, because the fiber in fruits promotes satiety and slows the absorption of the fructose. Fruit juice, on the other hand, lacks the fiber and allows more rapid absorption.

𝐇𝐅𝐂𝐒 has other harmful effects including changes seen in the first month of life where metabolic changes may endure the person’s entire life. Children of mothers who consume fructose have been shown to have increased risk of high body weight, increased food intake, and increased insulin resistance. In animal studies, when rodents were fed fructose or sucrose with no difference in caloric intake in either group, the ones fed fructose gained more weight than those fed sucrose. The fructose fed rodents developed the pattern of abdominal fat accumulation and elevated triglyceride blood levels seen in the dangerous 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐬𝐲𝐧𝐝𝐫𝐨𝐦𝐞, a comorbidity in Covid-19 that is recognized to increase rates of complications and death.

𝐇𝐅𝐂𝐒 has been shown to have a strong systemic 𝐩𝐫𝐨-𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐞 with an increase in circulating inflammation factors also seen in critically ill Covid-19 patients. These factors are implicated in the hyper-immune response (‘cytokine storm’) in the worst cases of Covid-19. In addition, HFCS impairs the antioxidant system that helps to keep in check the hyper-immune reaction that releases the damaging radicals that in Covid-19 is believed to cause the ARDS and vascular endothelial damage leading to vascular thrombosis and poor outcomes. This strong pro-inflammatory response results in 𝐨𝐱𝐢𝐝𝐚𝐭𝐢𝐯𝐞 𝐬𝐭𝐫𝐞𝐬𝐬 and generates the release of some of the same damaging agents implicated in the hyper-immune response (‘cytokine storm’) seen in the worst cases of Covid-19.

Tomorrow, more on 𝐇𝐢𝐠𝐡 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐒𝐲𝐫𝐮𝐩 𝐚𝐧𝐝 𝐋𝐢𝐯𝐞𝐫 𝐃𝐚𝐦𝐚𝐠𝐞.

06/18/2020

COVID – 19 Notes # 21

𝐇𝐞𝐥𝐩 𝐟𝐨𝐫 𝐒𝐢𝐜𝐤 𝐂𝐨𝐯𝐢𝐝 𝐏𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐛𝐮𝐭 𝐍𝐨 𝐒𝐢𝐥𝐯𝐞𝐫 𝐁𝐮𝐥𝐥𝐞𝐭

This week we heard about the Recovery Trial findings in the article, “Low-cost dexamethasone reduces death by up to one-third in hospitalized patients with severe respiratory complications of COVID-19”. 𝐃𝐞𝐱𝐚𝐦𝐞𝐭𝐡𝐚𝐬𝐨𝐧𝐞 is a steroid that was approved for medical use in 1961. It is readily available and is relatively inexpensive. Steroids have been used in a wide range of illnesses that are linked to inflammation among other conditions. In spite of this the World Health Organization disparaged the use of steroids saying that steroid treatment of COVID-19 patients should only be used in clinical trials. Many treating physicians were influenced by this and reframed from using steroids even though the hyper-immune inflammatory response, so called ‘cytokine storm’, they were seeing in sick hospitalized patients was the major contributor to mortality. But some physicians on the front line did use steroids and recognized the improvement in many seriously ill patients, many on ventilators. Dr. Paul Malik of Virginia is one such physician. He was impressed by his results and will probably publish his findings soon.

The study results released this week showed that in hospitalized patients needing oxygen therapy and given dexamethasone, the mortality was reduced 20% compared to a similar group not receiving dexamethasone. Put another way, 20 patients would need to be treated with dexamethasone in order to save one life {number needed to treat (NNT = 20)}. For patients on ventilators receiving dexamethasone, the reduction in mortality was 35% when compared to similar ventilator patients not treated with dexamethasone (NNT = 8 patients). By comparison the study of 𝐑𝐞𝐦𝐝𝐞𝐬𝐞𝐯𝐢𝐫 showed that 28 people would need to be treated in order to save one life (NNT = 28).

Now steroids will be used in more hospitalized COVID-19 patients, and another step in conquering this virus has been taken. This is no silver bullet, no cure. But it is progress.

06/08/2020

COVID – 19 Notes # 20

𝐇𝐲𝐝𝐫𝐨𝐱𝐲𝐜𝐡𝐥𝐨𝐫𝐨𝐪𝐮𝐢𝐧𝐞 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐃𝐚𝐭𝐚 𝐚𝐧𝐝 𝐀 𝐒𝐜𝐚𝐧𝐝𝐚𝐥

In COVID-19 Notes, # 7 and # 16, I made the point that hydroxychloroquine and chloroquine must be given along with 𝐙𝐈𝐍𝐂 in order for the intracellular activity to stop the replication of the virus. I also said that these combinations should be started 𝐄𝐀𝐑𝐋𝐘 before the viral replication creates an overwhelming burden and a hyper-immune response ensues. In 𝑇ℎ𝑒 𝐿𝑎𝑛𝑐𝑒𝑡 publication discussed below neither point was mentioned, and in fact Zinc was not listed as an agent administered. As you will read below the recent medical article that ‘put a nail in the coffin’ of hydroxychloroquine for COVID-19 (SARS CoV-2) as one physician remarked, was terribly flawed and probably used fraudulent data. Please read on to fully understand the scandalous nature of this medical analysis, such that the authors of the article themselves rejected it after it was published.

On May 22 in the prestigious British medical journal, 𝑇ℎ𝑒 𝐿𝑎𝑛𝑐𝑒𝑡, the findings of a multinational registry analysis of data from 671 hospitals on six continents composing more than 96,000 hospitalized patients treated with hydroxychloroquine or chloroquine with or without a macrolide (an antibiotic class that includes Azithromycin) and a control group that received none of these agents. The analysis was interpreted as follows, “We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.”

Even though this was a retrospective study, it was hailed as the end of the controversy about these drugs for the treatment of the virus. The WHO stopped its planned prospective study of the drugs. Then doubts began when investigators, seeking more information about the little-known data collection company, Surgisphere, found discrepancies and raised questions about its data authenticity and honesty. This led the authors of the study to request the data base for their review, and when Surgisphere refused, the authors requested 𝑇ℎ𝑒 𝐿𝑎𝑛𝑐𝑒𝑡 retract the article, which was done.

Still many fine and reputable physicians on the front line who have treated hundreds, if not thousands, of COVID-19 patients persist in their claim of the excellent results with these agents (plus zinc) in all ages and with all comorbidities, some having large series without a single mortality. They testify to hydroxychloroquine’s safety as well.

In time we will have more studies about the combination of hydroxychloroquine, azithromycin, and zinc. The hope is a large randomized prospective double-blind trial, designed well and honestly carried out, will give us definitive answers. In the meantime, there are some good studies, among then a believable French study, that show when the agents are given early with ZINC, bad outcomes are avoided and patients do well. Unfortunately, politics has had an impact on this issue, and alarms have been raised about the safety of hydroxychloroquine and chloroquine. These medications have been around for decades and millions of people have benefited from them. My son and I took chloroquine as an antimalarial while on extensive safaris in East Africa on several occasions. We, like many others, suffered no bad effects and were protected from malaria in areas where it was rampant.

05/27/2020

COVID-19 Notes # 19

𝐓𝐡𝐞 𝐃𝐞𝐚𝐝 𝐓𝐞𝐚𝐜𝐡 𝐭𝐡𝐞 𝐋𝐢𝐯𝐢𝐧𝐠

Over the door of autopsy rooms often seen in earlier days was the Latin inscription 𝑀𝑜𝑟𝑡𝑢𝑖 𝑣𝑖𝑣𝑜𝑠 𝑑𝑜𝑐𝑒𝑛𝑡… the dead teach the living.

On April 29 in 𝐂𝐎𝐕𝐈𝐃-𝟏𝟗 𝐍𝐨𝐭𝐞𝐬 #𝟔, 𝑇ℎ𝑟𝑜𝑚𝑏𝑜𝑠𝑖𝑠 𝑎𝑛𝑑 𝑆𝑡𝑟𝑜𝑘𝑒𝑠 and on May 4, #𝟗 𝐴 𝐷𝑖𝑠𝑒𝑎𝑠𝑒 𝑜𝑓 𝑡ℎ𝑒 𝐸𝑛𝑑𝑜𝑡ℎ𝑒𝑙𝑖𝑢𝑚, I wrote of the vasculature, i.e. the arteries and veins being affected by the virus at the endothelium, which is the single cell layer lining the inside of the arteries, veins and every capillary within the human body. ACE2 receptors on these endothelial cells were hypothesized to be the sites of attachment of the virus instigating a series of events leading to 𝐎𝐗𝐈𝐃𝐀𝐓𝐈𝐕𝐄 𝐒𝐓𝐑𝐄𝐒𝐒, which I explained was the “production of excess damaging radicals within the endothelial cells, a situation where the system is out of balance leading to more dysfunction and thrombosis”.

Last week on May 21, the 𝐍𝐞𝐰 𝐄𝐧𝐠𝐥𝐚𝐧𝐝 𝐉𝐨𝐮𝐫𝐧𝐚𝐥 𝐨𝐟 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 published the article 𝑃𝑢𝑙𝑚𝑜𝑛𝑎𝑟𝑦 𝑉𝑎𝑠𝑐𝑢𝑙𝑎𝑟 𝐸𝑛𝑑𝑜𝑡ℎ𝑒𝑙𝑖𝑎𝑙𝑖𝑡𝑖𝑠, 𝑇ℎ𝑟𝑜𝑚𝑏𝑜𝑠𝑖𝑠, 𝑎𝑛𝑑 𝐴𝑛𝑔𝑖𝑜𝑔𝑒𝑛𝑒𝑠𝑖𝑠 in Covid-19 in which the lungs of 7 patients who died from SARS Cov-2 (COVID-19) were studied. Photo micrographs and electron micrographs were included in the paper. These pathology studies were compared to those of lungs of patients who died of influenza-associated respiratory failure. The article stated in addition to diffuse damage to the lung tissue (alveolae), “The lungs from patients with Covid-19 also showed distinctive vascular features, consisting of severe endothelial injury associated with the presence of intracellular virus and disrupted cell membranes. Histologic analysis of pulmonary vessels in patients with Covid-19 showed widespread thrombosis with microangiopathy. Alveolar capillary microthrombi were 9 times as prevalent in patients with Covid-19.” Electron microscopy “showed ultrastructure damage to the endothelium, as well as the presence of intracellular SARS-CoV-2. The virus could also be identified in the extracellular space.”

The article stressed the following 3 pathologic findings in the lungs of COVID-19 patients:

1. Severe endothelial injury with intracellular SARS-CoV-2 virus

2. Widespread vascular thrombosis

3. New vessel growth attempts (angiogenesis)

These autopsy studies support the hypothesis that the hypoxia (low oxygen levels of the blood) of COVID-19 is in large part because of the clotting in the pulmonary arteries and in the small vessels responsible for the uptake of oxygen from the lung alveolae. In this regard the clinical findings have appeared as if the patient is suffering from high altitude sickness, which results from severe vasoconstriction of the pulmonary arteries from the low atmospheric oxygen concentration. Whereas in high altitude sickness, descending to lower altitude and increasing oxygen intake will often relieve the problem, in the ARDS of COVID-19 patients, the administration of oxygen offers little relief because of the diffuse thrombotic obstruction of the vasculature of the lungs preventing the uptake of the oxygen. This was not recognized only a few months ago, when mechanical ventilation was thought to be the primary treatment for the unresponsive severe hypoxia of many hospitalized COVID-19 patients. Now we know more and are beginning to piece it all together, as the COVID-19 patients who have died are teaching us.

05/22/2020

COVID-19 Notes # 18

𝐇𝐨𝐰 𝐭𝐨 𝐖𝐞𝐚𝐭𝐡𝐞𝐫 𝐭𝐡𝐞 𝐍𝐞𝐱𝐭 𝐏𝐚𝐧𝐝𝐞𝐦𝐢𝐜

𝐖𝐡𝐚𝐭 𝐰𝐞 𝐚𝐫𝐞 𝐮𝐩 𝐚𝐠𝐚𝐢𝐧𝐬𝐭.....𝐓𝐡𝐞 𝐄𝐥𝐞𝐩𝐡𝐚𝐧𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐑𝐨𝐨𝐦

𝐎𝐛𝐞𝐬𝐢𝐭𝐲, 𝐭𝐲𝐩𝐞 𝟐 𝐝𝐢𝐚𝐛𝐞𝐭𝐞𝐬 𝐚𝐧𝐝 𝐚 𝐜𝐥𝐮𝐬𝐭𝐞𝐫 𝐨𝐟 𝐫𝐢𝐬𝐤 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 𝐚𝐥𝐥 𝐥𝐢𝐧𝐤𝐞𝐝 𝐭𝐨 𝐩𝐨𝐨𝐫 𝐝𝐢𝐞𝐭 𝐢𝐬 𝐭𝐡𝐞 𝐫𝐨𝐨𝐭 𝐜𝐚𝐮𝐬𝐞 𝐛𝐞𝐡𝐢𝐧𝐝 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐝 𝐝𝐞𝐚𝐭𝐡 𝐫𝐚𝐭𝐞𝐬 𝐨𝐟 𝐜𝐨𝐫𝐨𝐧𝐚𝐯𝐢𝐫𝐮𝐬 – Dr. Robert Lustig

Only 1 out of 8 adults is metabolically healthy

Obesity, type 2 diabetes and metabolic syndrome appear to be associated with a 10-fold increase in death with this virus.

Definition of 𝐌𝐄𝐓𝐀𝐁𝐎𝐋𝐈𝐂 𝐒𝐘𝐍𝐃𝐑𝐎𝐌𝐄 - present If 3 or more of the following 5 criteria are present:

1. Waist circumference over 40 inches in men or 35 inches in women

2. Blood pressure over 130/85 mm Hg

3. Fasting triglyceride level over 150 mg/dl

4. HDL cholesterol, the “good cholesterol”, less than 40 mg/dl in men or less than 50 mg/dl in

women

5. Elevated fasting blood sugar of 100 mg/dl or higher

𝐔𝐋𝐓𝐑𝐀-𝐏𝐑𝐎𝐂𝐄𝐒𝐒𝐄𝐃 𝐅𝐎𝐎𝐃 𝐢𝐬 𝐭𝐡𝐞 𝐩𝐫𝐢𝐧𝐜𝐢𝐩𝐚𝐥 𝐩𝐫𝐨𝐛𝐥𝐞𝐦 𝐚𝐧𝐝 𝐦𝐚𝐤𝐞𝐬 𝐮𝐩 𝐎𝐕𝐄𝐑 𝟓𝟎% 𝐨𝐟 𝐦𝐨𝐬𝐭 𝐀𝐦𝐞𝐫𝐢𝐜𝐚𝐧𝐬' 𝐜𝐚𝐥𝐨𝐫𝐢𝐜 𝐢𝐧𝐭𝐚𝐤𝐞...𝐁𝐌𝐉

Definitions: 𝐔𝐍𝐏𝐑𝐎𝐂𝐄𝐒𝐒𝐄𝐃 𝐨𝐫 𝐌𝐈𝐍𝐈𝐌𝐀𝐋𝐋𝐘 𝐏𝐑𝐎𝐂𝐄𝐒𝐒𝐄𝐃 𝐅𝐎𝐎𝐃𝐒 𝐚𝐫𝐞 𝐰𝐡𝐨𝐥𝐞 𝐟𝐨𝐨𝐝𝐬 𝐢𝐧 𝐰𝐡𝐢𝐜𝐡 𝐭𝐡𝐞 𝐯𝐢𝐭𝐚𝐦𝐢𝐧𝐬 𝐚𝐧𝐝 𝐧𝐮𝐭𝐫𝐢𝐞𝐧𝐭𝐬 𝐚𝐫𝐞 𝐬𝐭𝐢𝐥𝐥 𝐩𝐫𝐞𝐬𝐞𝐧𝐭. 𝐄𝐱𝐚𝐦𝐩𝐥𝐞𝐬 𝐚𝐫𝐞 𝐚𝐩𝐩𝐥𝐞𝐬, 𝐜𝐚𝐫𝐫𝐨𝐭𝐬, 𝐫𝐚𝐰 𝐜𝐡𝐢𝐜𝐤𝐞𝐧, 𝐫𝐚𝐰 𝐮𝐧𝐬𝐚𝐥𝐭𝐞𝐝 𝐧𝐮𝐭𝐬.

𝐏𝐑𝐎𝐂𝐄𝐒𝐒𝐄𝐃 𝐅𝐎𝐎𝐃𝐒 𝐚𝐫𝐞 𝐜𝐡𝐚𝐧𝐠𝐞𝐝 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐧𝐚𝐭𝐮𝐫𝐚𝐥 𝐬𝐭𝐚𝐭𝐞 𝐛𝐲 𝐚𝐝𝐝𝐢𝐧𝐠 𝐬𝐚𝐥𝐭, 𝐨𝐢𝐥, 𝐬𝐮𝐠𝐚𝐫, 𝐨𝐫 𝐨𝐭𝐡𝐞𝐫 𝐬𝐮𝐛𝐬𝐭𝐚𝐧𝐜𝐞𝐬. 𝐄𝐱𝐚𝐦𝐩𝐥𝐞𝐬 𝐚𝐫𝐞 𝐜𝐚𝐧𝐧𝐞𝐝 𝐟𝐢𝐬𝐡 𝐨𝐫 𝐜𝐚𝐧𝐧𝐞𝐝 𝐯𝐞𝐠𝐞𝐭𝐚𝐛𝐥𝐞𝐬, 𝐟𝐫𝐮𝐢𝐭𝐬 𝐢𝐧 𝐬𝐲𝐫𝐮𝐩.

𝐔𝐋𝐓𝐑𝐀 𝐨𝐫 𝐇𝐈𝐆𝐇𝐋𝐘 𝐏𝐑𝐎𝐂𝐄𝐒𝐒𝐄𝐃 𝐅𝐎𝐎𝐃𝐒 𝐡𝐚𝐯𝐞 𝐦𝐚𝐧𝐲 𝐚𝐝𝐝𝐞𝐝 𝐢𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐬 (𝐬𝐮𝐠𝐚𝐫, 𝐬𝐚𝐥𝐭, 𝐟𝐚𝐭, 𝐚𝐫𝐭𝐢𝐟𝐢𝐜𝐢𝐚𝐥 𝐜𝐨𝐥𝐨𝐫, 𝐩𝐫𝐞𝐬𝐞𝐫𝐯𝐚𝐭𝐢𝐯𝐞𝐬). 𝐔𝐥𝐭𝐫𝐚-𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐝 𝐟𝐨𝐨𝐝𝐬 𝐚𝐫𝐞 𝐦𝐨𝐬𝐭𝐥𝐲 𝐦𝐚𝐝𝐞 𝐟𝐫𝐨𝐦 𝐬𝐮𝐛𝐬𝐭𝐚𝐧𝐜𝐞𝐬 𝐞𝐱𝐭𝐫𝐚𝐜𝐭𝐞𝐝 𝐟𝐫𝐨𝐦 𝐟𝐨𝐨𝐝, 𝐬𝐮𝐜𝐡 𝐚𝐬 𝐟𝐚𝐭𝐬, 𝐬𝐭𝐚𝐫𝐜𝐡𝐞𝐬, 𝐚𝐝𝐝𝐞𝐝 𝐬𝐮𝐠𝐚𝐫𝐬, 𝐡𝐲𝐝𝐫𝐨𝐠𝐞𝐧𝐚𝐭𝐞𝐝 𝐟𝐚𝐭𝐬. 𝐄𝐱𝐚𝐦𝐩𝐥𝐞𝐬 𝐚𝐫𝐞 𝐟𝐫𝐨𝐳𝐞𝐧 𝐦𝐞𝐚𝐥𝐬, 𝐡𝐨𝐭 𝐝𝐨𝐠𝐬, 𝐬𝐨𝐟𝐭 𝐝𝐫𝐢𝐧𝐤𝐬, 𝐟𝐚𝐬𝐭 𝐟𝐨𝐨𝐝, 𝐩𝐚𝐜𝐤𝐚𝐠𝐞𝐝 𝐜𝐨𝐨𝐤𝐢𝐞𝐬, 𝐜𝐚𝐤𝐞𝐬 𝐚𝐧𝐝 𝐬𝐚𝐥𝐭𝐲 𝐬𝐧𝐚𝐜𝐤𝐬.

In this time of the virus many Americans have put themselves in danger because of poor dietary habits and nutrition. A whole generation has grown up eating junk food, eating out of a box. This is the 𝐄𝐥𝐞𝐩𝐡𝐚𝐧𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐫𝐨𝐨𝐦.Now is the time to embrace some healthy changes, changes that will reverse obesity, put diabetes type 2 in permanent remission, improve our metabolic health, strengthen our immune system and make us less vulnerable to this and any future virus. 𝐀𝐦𝐞𝐫𝐢𝐜𝐚𝐧𝐬 𝐜𝐚𝐧 𝐬𝐭𝐚𝐫𝐭 𝐧𝐨𝐰 𝐛𝐲 𝐫𝐞𝐣𝐞𝐜𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐡𝐢𝐠𝐡𝐥𝐲 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐝 𝐚𝐧𝐝 𝐮𝐥𝐭𝐫𝐚-𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐝 𝐣𝐮𝐧𝐤 𝐟𝐨𝐨𝐝𝐬 𝐚𝐧𝐝 𝐜𝐨𝐧𝐬𝐮𝐦𝐞 𝐧𝐮𝐭𝐫𝐢𝐞𝐧𝐭 𝐝𝐞𝐧𝐬𝐞 𝐦𝐢𝐧𝐢𝐦𝐚𝐥𝐥𝐲 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐝 𝐰𝐡𝐨𝐥𝐞 𝐟𝐨𝐨𝐝𝐬 𝐥𝐢𝐤𝐞 𝐨𝐮𝐫 𝐠𝐫𝐚𝐧𝐝𝐩𝐚𝐫𝐞𝐧𝐭𝐬 𝐚𝐭𝐞.

05/19/2020

COVID Notes # 17

𝐀 𝐒𝐢𝐥𝐯𝐞𝐫 𝐁𝐮𝐥𝐥𝐞𝐭 𝐟𝐨𝐫 𝐭𝐡𝐞 𝐕𝐢𝐫𝐮𝐬...𝐏𝐞𝐫𝐡𝐚𝐩𝐬?

Study of the addition of a supplement that is readily available without prescription is about to take place in COVID-19 infected patients. The working hypothesis is that the administration of 𝐍𝐀𝐂 (𝐍-𝐚𝐜𝐞𝐭𝐲𝐥𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞) may prevent the hyper-immune response that leads to the severe lung changes and vascular changes that lead to serious complications and sadly in some, death. There is already good data on this agent showing that it decreases the course of influenza by 50%, inhibits viral replication and reduces the inflammatory syndrome associated with “cytokine storm”, reduces the length of ICU stay in ARDS patients, reduces the brain injury in stroke patients, has a beneficial effect on abnormal clotting and aids in break up (thrombolytic effect) and removal of arterial clots. There are other advantages that NAC offers our health including anti-aging effects with no serious adverse consequences. Sounds too good to be true, I know.

NAC is a building block for the biosynthesis of 𝐆𝐋𝐔𝐓𝐀𝐓𝐇𝐈𝐎𝐍𝐄, a master antioxidant that reverses oxidative stress, the process that generates the damaging radicals that are responsible for the hyper-immune response mentioned above. Many of us are deficient in glutathione levels in our body because of a frequently found genetic snip in our DNA, i.e. we do not make enough of it. Patients with asthma and many other chronic ENT diseases are severely deficient in glutathione. Taking NAC literally recharges our levels of glutathione. In COVID-19, NAC is not a cure, but it may significantly reduce the course of disease and the complications that lead to prolonged ICU care and severe pulmonary and vascular dysfunction. The first studies will be retrospective and uncontrolled. The results will be interesting, and if promising, further controlled studies will come. I take NAC 500mg twice a day. If one is on anticoagulants (blood thinners) because of NAC’s anti-thrombotic action, one should consult one’s physician before use.

05/18/2020

COVID-19 Notes # 15

𝐇𝐨𝐰 𝐖𝐞 𝐂𝐨𝐧𝐭𝐫𝐚𝐜𝐭 𝐭𝐡𝐞 𝐕𝐢𝐫𝐮𝐬

𝐀𝐈𝐑𝐁𝐎𝐑𝐍𝐄 𝐒𝐎𝐔𝐑𝐂𝐄𝐒

𝐀 𝐒𝐍𝐄𝐄𝐙𝐄 – releases about 𝟑𝟎,𝟎𝟎𝟎 𝐝𝐫𝐨𝐩𝐥𝐞𝐭𝐬, 𝐭𝐫𝐚𝐯𝐞𝐥𝐢𝐧𝐠 𝐮𝐩 𝐭𝐨 𝟐𝟎𝟎 𝐦𝐢𝐥𝐞𝐬 𝐩𝐞𝐫 𝐡𝐨𝐮𝐫 and may release as many as 𝟐𝟎𝟎,𝟎𝟎𝟎,𝟎𝟎𝟎 (𝐭𝐰𝐨 𝐡𝐮𝐧𝐝𝐫𝐞𝐝 𝐦𝐢𝐥𝐥𝐢𝐨𝐧) 𝐯𝐢𝐫𝐚𝐥 𝐩𝐚𝐫𝐭𝐢𝐜𝐥𝐞𝐬 that are dispersed in a large surrounding area where, as small droplets, they may linger in the air. A sneeze is the worst.

𝐀 𝐂𝐎𝐔𝐆𝐇 – releases about 𝟑,𝟎𝟎𝟎 𝐝𝐫𝐨𝐩𝐥𝐞𝐭𝐬, 𝐭𝐫𝐚𝐯𝐞𝐥𝐢𝐧𝐠 𝐚𝐭 𝟓𝟎 𝐦𝐢𝐥𝐞𝐬 𝐩𝐞𝐫 𝐡𝐨𝐮𝐫; most of the droplets are large and fall quickly but smaller ones stay suspended in the air and can travel across a room

𝐀 𝐁𝐑𝐄𝐀𝐓𝐇 – single breaths release from 𝟓𝟎 𝐭𝐨 𝟓,𝟎𝟎𝟎 𝐝𝐫𝐨𝐩𝐥𝐞𝐭𝐬 which travel at low velocity and fall quickly. Fewer droplets are released from nose breaths than from mouth breathing. The lowered exhalation force of a normal breath means that viral particles from the lower respiratory system are not expelled. The cumulative viral count in breaths of infectious individuals goes up as the number of breaths exhaled.

𝐒𝐏𝐄𝐀𝐊𝐈𝐍𝐆 – increases the release of droplets about 10-fold or about 𝟐𝟎𝟎 𝐯𝐢𝐫𝐮𝐬 𝐩𝐚𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐩𝐞𝐫 𝐦𝐢𝐧𝐮𝐭𝐞𝐬. It would take 5 minutes of inhaling all these viral particles to reach the hypothetical 1,000 viral particle threshold for infection. Loud talking expels more viral particles than normal conversation.

𝐒𝐔𝐑𝐅𝐀𝐂𝐄 𝐂𝐎𝐍𝐓𝐀𝐂𝐓

𝐒𝐔𝐑𝐅𝐀𝐂𝐄𝐒 – especially in public bathrooms – Treat with Caution the door handles, faucets doors and surfaces.

We know this virus is very contagious, but how much of this virus is necessary to establish an infection? The short and accurate answer is that we do not know, but some experts estimate that as few as 1000 SARS-CoV2 viral particles are sufficient to bring on infection. An infectious dose may result from an eye rub or from one or more breath inhalations.

𝐓𝐡𝐞 𝐫𝐢𝐬𝐤 𝐨𝐟 𝐢𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐧 𝐢𝐧 𝐚𝐧 𝐨𝐮𝐭𝐝𝐨𝐨𝐫 𝐞𝐧𝐯𝐢𝐫𝐨𝐧𝐦𝐞𝐧𝐭 𝐰𝐢𝐭𝐡 𝐩𝐡𝐲𝐬𝐢𝐜𝐚𝐥 𝐝𝐢𝐬𝐭𝐚𝐧𝐜𝐢𝐧𝐠 𝐢𝐬 𝐪𝐮𝐢𝐭𝐞 𝐥𝐨𝐰.

𝐓𝐡𝐞 𝐠𝐫𝐞𝐚𝐭𝐞𝐬𝐭 𝐫𝐢𝐬𝐤 𝐨𝐟 𝐢𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐧 𝐜𝐨𝐦𝐞𝐬 𝐟𝐫𝐨𝐦 𝐥𝐨𝐧𝐠 𝐩𝐞𝐫𝐢𝐨𝐝𝐬 𝐨𝐟 𝐭𝐢𝐦𝐞 𝐰𝐢𝐭𝐡 𝐠𝐫𝐨𝐮𝐩𝐬 𝐨𝐟 𝐩𝐞𝐨𝐩𝐥𝐞 𝐢𝐧 𝐜𝐨𝐧𝐟𝐢𝐧𝐞𝐝 𝐬𝐩𝐚𝐜𝐞𝐬 𝐢𝐧𝐝𝐨𝐨𝐫𝐬. According to Erin Bromage, Associate Professor of Biology and Comparative Immunologist of the University of Massachusetts Dartmouth, from whom much of this information comes,“The main sources for infection are home, workplace, public transport, social gatherings, and restaurants. This accounts for 90% of all transmission events. In contrast, outbreaks spread from shopping appear to be responsible for a small percentage of traced infections.”

05/18/2020

COVID-19 Notes # 16

𝐇𝐲𝐝𝐫𝐨𝐱𝐲𝐜𝐡𝐥𝐨𝐫𝐨𝐪𝐮𝐢𝐧𝐞, 𝐀𝐳𝐢𝐭𝐡𝐫𝐨𝐦𝐲𝐜𝐢𝐧, 𝐚𝐧𝐝 𝐙𝐢𝐧𝐜 𝐑𝐞𝐯𝐢𝐬i𝐭𝐞𝐝

Recently more information about the pharmaceutical agents, hydroxychloroquine and azithromycin and the supplement zinc in the treatment of COVID-19 has become available from a recent retrospective study on patients with COVID-19 admitted to New York University School of Medicine. In COVID-19 Notes # 7, the role of hydroxychloroquine was explained. Zinc as an ion cannot cross the cell membrane. Hydroxychloroquine, acting as an ionophore, “opens a gate” at the cell wall and allows Zinc to enter the virus infected cell. Once in the cell the Zinc stops the making of new viruses by shutting down the replicating enzyme, replicase (RNA dependent RNA polymerase). The result is the cessation of new virus particles, a decrease in the viral load and resolution of the illness. 𝐈𝐧 𝐞𝐚𝐫𝐥𝐢𝐞𝐫 𝐰𝐫𝐢𝐭𝐢𝐧𝐠, 𝐈 𝐬𝐭𝐫𝐞𝐬𝐬𝐞𝐝 𝐭𝐡𝐚𝐭 𝐭𝐡𝐞𝐬𝐞 𝐚𝐠𝐞𝐧𝐭𝐬 𝐰𝐨𝐮𝐥𝐝 𝐰𝐨𝐫𝐤 𝐛𝐞𝐬𝐭 𝐢𝐟 𝐬𝐭𝐚𝐫𝐭𝐞𝐝 𝐛𝐞𝐟𝐨𝐫𝐞 𝐭𝐡𝐞 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 𝐩𝐫𝐨𝐠𝐫𝐞𝐬𝐬𝐞𝐝 𝐭𝐨 𝐚𝐧 𝐨𝐯𝐞𝐫𝐰𝐡𝐞𝐥𝐦𝐢𝐧𝐠 𝐯𝐢𝐫𝐚𝐥 𝐥𝐨𝐚𝐝 𝐚𝐧𝐝 𝐟𝐮𝐥𝐥-𝐛𝐥𝐨𝐰𝐧 𝐩𝐧𝐞𝐮𝐦𝐨𝐧𝐢𝐚 𝐰𝐚𝐬 𝐞𝐬𝐭𝐚𝐛𝐥𝐢𝐬𝐡𝐞𝐝.

The study looked at hydroxychloroquine and azithromycin treated patients and then at patients given the 2 drugs plus zinc. There were 411 patients in the Zinc group and 521 in the No Zinc group. Addition of zinc to the hydroxychloroquine and azithromycin showed a significant decrease in mortality or transition to hospice among patients that did not require ICU care but was not significant for those needing ICU care. In other words, once the severity of disease reached a level requiring the ICU, with immune mediators bringing on what is termed cytokine storm and ARDS, the addition of zinc appeared to be ineffective. The conclusion was that the addition of zinc to hydroxychloroquine and azithromycin showed therapeutic value if used early or at presentation of disease. 𝐀𝐠𝐚𝐢𝐧, 𝐭𝐡𝐞 𝐩𝐨𝐢𝐧𝐭 𝐢𝐬 𝐭𝐡𝐚𝐭 𝐭𝐡𝐞 𝐜𝐨𝐦𝐛𝐢𝐧𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞𝐬𝐞 𝐝𝐫𝐮𝐠𝐬 𝐚𝐧𝐝 𝐳𝐢𝐧𝐜 𝐦𝐮𝐬𝐭 𝐛𝐞 𝐬𝐭𝐚𝐫𝐭𝐞𝐝 𝐞𝐚𝐫𝐥𝐲, 𝐛𝐞𝐟𝐨𝐫𝐞 𝐭𝐡𝐞𝐫𝐞 𝐢𝐬 𝐞𝐱𝐭𝐞𝐧𝐬𝐢𝐯𝐞 𝐢𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐯𝐢𝐫𝐮𝐬 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐡𝐚𝐬 𝐩𝐫𝐨𝐝𝐮𝐜𝐞𝐝 𝐚 𝐡𝐮𝐠𝐞 𝐯𝐢𝐫𝐚𝐥 𝐥𝐨𝐚𝐝 𝐰𝐢𝐭𝐡 𝐭𝐡𝐞 𝐜𝐨𝐧𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐞𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐡𝐲𝐩𝐞𝐫-𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐞 𝐚𝐧𝐝 𝐬𝐞𝐯𝐞𝐫𝐞 𝐩𝐮𝐥𝐦𝐨𝐧𝐚𝐫𝐲 𝐝𝐲𝐬𝐟𝐮𝐜𝐭𝐢𝐨𝐧.

05/14/2020

COVID-19 Notes # 14

𝐊𝐚𝐰𝐚𝐬𝐚𝐤𝐢 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 𝐢𝐧 𝐕𝐢𝐫𝐮𝐬 𝐈𝐧𝐟𝐞𝐜𝐭𝐞𝐝 𝐂𝐡𝐢𝐥𝐝𝐥𝐫𝐞𝐧

Recent news has reported a number of young children who have manifested findings of a rare disease, Kawasaki disease, which is thought to be of unknown cause. The symptoms and findings include fever, conjunctival congestion, changes in oral cavity and lips including bright red lips and red “strawberry” tongue, infection of the mucosal lined pharyngeal and oral cavities, redness of the soles of feet and palms of hands with edema and prominent lymph nodes in the neck. On pathologic study there is inflammation of medium-sized muscular arteries throughout the body. This disease is thought to be the result of a pathogen, likely a virus, that invades the child’s body through the lungs or gastrointestinal tract. This leads to a systemic vasculitis where there is diffuse inflammation of the blood vessels, especially the arteries, resulting from the body’s immune system going to war with the invading virus.

In COVID-19 Notes # 9, I gave evidence that the COVID-19 virus may enter by the respiratory tract and then spread to the arteries and veins attacking the inner lining of the arteries and veins, the endothelium. It appears that in earlier descriptions of Kawasaki disease the initial attack was at this endothelium, and in some cases the lungs were involved secondarily. What is being seen in a small group of young children with COVID-19 infections is strikingly similar to what has been described in Kawasaki disease, i.e. a systemic vasculitis, with high mortality rates.

Address

8722 Greenville Avenue, Suite 101
Dallas, TX
75243

Opening Hours

Tuesday 8:30am - 5pm
Wednesday 8:30am - 5pm
Thursday 8am - 5pm
Friday 8am - 4pm

Telephone

(214) 221-9222

Alerts

Be the first to know and let us send you an email when Dallas Vein Specialists posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Business

Send a message to Dallas Vein Specialists:

Videos

Share

Category


Comments

New featured review on www.yellowpages.com
Dr. Whidden knows, and knows that he knows. A true professional.
https://bit.ly/3sCyGKs
New featured review on search.google.com
Dr. Whiddon is amazing and Im so grateful I found him. He and his team are professional and so nice and he cares about the results and patient satisfaction. I required extra treatments beyond the initial plan and he performed them at not additional cost, and assured me if after some more healing time I decided I needed more treatments that would be covered as well. Im so happy with my results, thank you!
https://bit.ly/2DP8UeP
Dallas Vein Specialists – take appropriate precautions in this time of the viral pandemic
A Disease of the Endothelium
Diet and Lifestyle Driving the Risks for COVID-19
How We Contract the Virus
Vaccine Hopes and Doubts
The Importance of SLEEP
Pre-existing Chronic Disease Puts COVID-19 Patients in Hospital
High Risk for COVID-19
COVID-19 Notes # 22

𝐇𝐢𝐠𝐡 𝐑𝐢𝐬𝐤 𝐟𝐫𝐨𝐦 𝐇𝐢𝐠𝐡 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐒𝐲𝐫𝐮𝐩 - 𝐏𝐚𝐫𝐭 𝐈𝐈 -- 𝐋𝐢𝐯𝐞𝐫 𝐃𝐚𝐦𝐚𝐠𝐞

𝐇𝐢𝐠𝐡 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐒𝐲𝐫𝐮𝐩 (𝐇𝐅𝐂𝐒) became available about 40 years ago. It was cheap, available and easily transported. Processed foodstuffs had become labeled as ‘reduced fat’, and instead of fat, food companies added sugar to make their products palatable. HFCS was and remains the easiest and cheapest additive for food companies to deliver this palatability. There is not one biochemical reaction in the human body that requires fructose, i.e. there is no need for fructose to be in our foods.

Fructose in small amounts, as found in fruit, is not a threat, but in high doses fructose is damaging to the body, especially the liver. Dr. Robert Lustig of UCSF, a pediatric neuroendocrinologist has been sounding the alarm for years about the dangers of consuming fructose in high amounts, think HFCS. He has written and talked extensively of the damage we are doing to ourselves and our children by our increasing consumption of HFCS. He believes that fructose is as bad as alcohol in causing the liver to store fat resulting in 𝐟𝐚𝐭𝐭𝐲 𝐥𝐢𝐯𝐞𝐫 𝐝𝐢𝐬𝐞𝐚𝐬𝐞, now alarmingly being increasingly seen in young children, and thus has detrimental effects beyond its calories in ways similar to ethanol (grain alcohol). Lustig has said, “Indeed, the only distinction is that because fructose is not metabolized in the central nervous system, it does not exert the acute neuronal depression experienced by those imbibing ethanol. These metabolic and hedonic analogies argue that fructose should be thought of as ‘alcohol without the buzz!’”

Fructose is not metabolized like glucose. As HFCS, fructose metabolites overwhelm the liver’s capacity, which drives 𝐥𝐢𝐩𝐨𝐠𝐞𝐧𝐞𝐬𝐢𝐬(production of fats in the liver) and leads to 𝐡𝐞𝐩𝐚𝐭𝐢𝐜 𝐢𝐧𝐬𝐮𝐥𝐢𝐧 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞, changes which cause chronic metabolic disease. (In the development of fatty liver, 𝐡𝐞𝐩𝐚𝐭𝐢𝐜 𝐬𝐭𝐞𝐚𝐭𝐨𝐬𝐢𝐬, high fructose consumption again mimics high ethanol consumption. 𝑃𝑎𝑟𝑎𝑐𝑒𝑙𝑠𝑢𝑠: 𝑇ℎ𝑒 𝑑𝑜𝑠𝑒 𝑑𝑒𝑡𝑒𝑟𝑚𝑖𝑛𝑒𝑠 𝑡ℎ𝑒 𝑝𝑜𝑖𝑠𝑜𝑛) The vicious cycle of hepatic insulin resistance, leading to increasing insulin secretion, leading to obesity, leading to worsening insulin resistance, finally leads to inadequate insulin secretion in relation to the degree of peripheral insulin resistance and 𝒕𝒚𝒑𝒆 2 𝒅𝒊𝒂𝒃𝒆𝒕𝒆𝒔. All the while in the background fructose is driving changes in the brain’s reward system undermining satiety with increased palatability and pushing for excessive consumption.

In summary of the prior Covid-19 and this one, # 22 and # 23,

𝐇𝐅𝐂𝐒 𝐞𝐟𝐟𝐞𝐜𝐭𝐬: 𝐡𝐲𝐩𝐞𝐫𝐢𝐧𝐬𝐮𝐥𝐢𝐧𝐞𝐦𝐢𝐚

𝐨𝐱𝐢𝐝𝐚𝐭𝐢𝐯𝐞 𝐬𝐭𝐫𝐞𝐬𝐬 𝐰𝐢𝐭𝐡 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐝𝐚𝐦𝐚𝐠𝐢𝐧𝐠 𝐫𝐚𝐝𝐢𝐜𝐚𝐥𝐬 (as in Covid-19)

𝐟𝐚𝐭𝐭𝐲 𝐥𝐢𝐯𝐞𝐫 (𝐡𝐞𝐩𝐚𝐭𝐢𝐜 𝐬𝐭𝐞𝐚𝐭𝐨𝐬𝐢𝐬)

𝐢𝐧𝐬𝐮𝐥𝐢𝐧 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞(a Covid-19 comorbidity risk)

𝐩𝐚𝐧𝐜𝐫𝐞𝐚𝐭𝐢𝐜 𝐛𝐞𝐭𝐚 𝐜𝐞𝐥𝐥 𝐞𝐱𝐡𝐚𝐮𝐬𝐭𝐢𝐨𝐧 (𝐫𝐞𝐝𝐮𝐜𝐞𝐝 𝐢𝐧𝐬𝐮𝐥𝐢𝐧 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧 𝐫𝐞𝐥𝐚𝐭𝐢𝐯𝐞 𝐭𝐨 𝐧𝐞𝐞𝐝)diabetes (a Covid-19 comorbidity risk)

𝐨𝐛𝐞𝐬𝐢𝐭𝐲 (a Covid-19 comorbidity risk)

𝐞𝐥𝐞𝐯𝐚𝐭𝐞𝐝 𝐭𝐫𝐢𝐠𝐥𝐲𝐜𝐞𝐫𝐢𝐝𝐞𝐬, 𝐞𝐥𝐞𝐯𝐚𝐭𝐞𝐝 𝐋𝐃𝐋 𝐚𝐧𝐝 𝐝𝐞𝐩𝐫𝐞𝐬𝐬𝐞𝐝 𝐇𝐃𝐋 𝐜𝐡𝐨𝐥𝐞𝐬𝐭𝐞𝐫𝐨𝐥 𝐥𝐞𝐯𝐞𝐥𝐬

𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐬𝐲𝐧𝐝𝐫𝐨𝐦𝐞 (a Covid-19 comorbidity risk)

So how do we avoid 𝐇𝐅𝐂𝐒 and all its detrimental effects? The simple answer is to begin to 𝐑𝐄𝐀𝐃 𝐈𝐍𝐆𝐑𝐄𝐃𝐈𝐄𝐍𝐓𝐒 in anything we consider buying in food stores. Look for 𝐡𝐢𝐠𝐡 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐜𝐨𝐫𝐧 𝐬𝐲𝐫𝐮𝐩 (𝐇𝐅𝐂𝐒) or simply 𝐜𝐨𝐫𝐧 𝐬𝐲𝐫𝐮𝐩. Do not be tricked by big food companies and be aware that this additive may be listed under 𝐨𝐭𝐡𝐞𝐫 𝐧𝐚𝐦𝐞𝐬listed below:

𝐆𝐥𝐮𝐜𝐨𝐬𝐞-𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐆𝐥𝐮𝐜𝐨𝐬𝐞-𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐬𝐲𝐫𝐮𝐩

𝐈𝐬𝐨𝐠𝐥𝐮𝐜𝐨𝐬𝐞

𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐜𝐨𝐫𝐧 𝐬𝐲𝐫𝐮𝐩

𝐈𝐬𝐨𝐥𝐚𝐭𝐞𝐝 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐌𝐚𝐢𝐳𝐞 𝐬𝐲𝐫𝐮𝐩

𝐆𝐥𝐮𝐜𝐨𝐬𝐞/𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞 𝐬𝐲𝐫𝐮𝐩

𝐓𝐚𝐩𝐢𝐨𝐜𝐚 𝐬𝐲𝐫𝐮𝐩

𝐆𝐥𝐮𝐜𝐨𝐬𝐞 𝐬𝐲𝐫𝐮𝐩

𝐃𝐚𝐡𝐥𝐢𝐚 𝐬𝐲𝐫𝐮𝐩

𝐅𝐫𝐮𝐢𝐭 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

𝐂𝐫𝐲𝐬𝐭𝐚𝐥𝐥𝐢𝐧𝐞 𝐟𝐫𝐮𝐜𝐭𝐨𝐬𝐞

Do not forget to check “juice cocktails”, cereals, sodas, yogurt, salad dressings, granola/energy/nutrition bars, etc. You will be surprised by what you find.