EDS Zebra Articles

09/16/2025

2025 Varied Presentations of Arterial Events in Vascular Ehlers-Danlos Syndrome

AbstractSpontaneous arterial aneurysms and dissections are relatively common in patients with vascular Ehlers-Danlos syndrome, and arterial rupture accounts for most deaths. Members of the Aortic a...

09/16/2025

2025 Conservative Management of Massive Retroperitoneal Hemorrhage in a Patient with Vascular Ehlers-Danlos Syndrome: A Case Report

Retroperitoneal hemorrhage in patients with vascular Ehlers-Danlos syndrome (vEDS) is uncommon, and its optimal management remains controversial because both surgical and endovascular interventions carry substantial risks. A 36-year-old man with ...

09/10/2025

2025 Mitral annular disjunction distance is associated with adverse outcomes in children and young adults with connective tissue disorders

A small MAD distance can be measured in healthy children and young adults. Children and young adults with CTD have a longer MAD distance than healthy control subjects, and a longer MAD distance is associated with adverse outcomes.

09/09/2025

2025 Median arcuate ligament syndrome: challenges, comorbidities, and controversies

Patients with MALS deserve a comprehensive multidisciplinary team to address their health. There is also a desperate need for collaborative research including randomized control trials in adults and a multicenter patient registry.

09/09/2025

2025 Postdural Puncture Headache in a Patient With Thoracic Arachnoid Web With Known Joint Hypermobility: Case Report

BACKGROUND: Patients with connective tissue disorders (CTDs), such as Ehlers-Danlos syndrome, can present unique challenges in the management of spinal pathology and procedural complications due to underlying tissue fragility and susceptibility to dural ruptures. Thus, there is a need for less invas...

09/08/2025

2025 KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome

https://www.sciencedirect.com/science/article/pii/S2589004225016049?fbclid=IwZnRzaAMrj3NleHRuA2FlbQIxMAABHjo_MqQc6Z3YFVYkGkoIbvOUe7upUuD32JT0QrncF3zRAlimibdiYR5Qse2__aem_-9t6KqXeZ0TNJdEoOkmhvg

Hypermobile Ehlers-Danlos syndrome (hEDS) is a debilitating multisystem condition characterized by joint hypermobility, chronic pain, and diverse como…

09/01/2025

2025 B3GALT6 mutations lead to compromised connective tissue biomechanics in Ehlers-Danlos syndrome

https://www.researchgate.net/publication/394979787_B3GALT6_mutations_lead_to_compromised_connective_tissue_biomechanics_in_Ehlers-Danlos_syndrome/fulltext/68aeda6fd9261f6f51af2ebb/B3GALT6-mutations-lead-to-compromised-connective-tissue-biomechanics-in-Ehlers-Danlos-syndrome.pdf?origin=publication_detail&_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uRG93bmxvYWQiLCJwcmV2aW91c1BhZ2UiOiJwdWJsaWNhdGlvbiJ9fQ&fbclid=IwQ0xDSwMiZn1leHRuA2FlbQIxMQABHhI4hleqMNLhJesZ5XkpsaIWZSNxvL4n7kRsqVOAdWsAy-kSOp6tHV3lvsVv_aem_M1f1-02y6mW810LLa45N6g

08/31/2025

2025 Defining the Chronic Complexities of hEDS and HSD: A Global Survey of Diagnostic Challenges, Life-Long Comorbidities, and Unmet Needs

Background: Hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSDs) are prevalent, complex conditions marked by chronic pain, joint instability, and multisystem involvement. Despite affecting an estimated 1 in 500 individuals, these conditions remain poorly understood...

08/31/2025

2025 Unveiling the Spectrum: Clinical and Molecular Insights from a Spanish Pediatric Cohort with Hypermobility Disorders and Ehlers-Danlos Syndrome

Diagnosing hypermobility disorders and Ehlers-Danlos syndrome (EDS) in children is challenging due to overlapping features with generalized joint hypermobility (GJH) and the lack of biomarkers. Background/Objectives: This study aims to describe the clinical and genetic features of pediatric EDS pati...

08/26/2025

2025 Exploring patient experiences of pain fatigue and physical activity in syndromic heritable thoracic aortic disease using mixed methods

The combination of chronic pain, fatigue, physical activity restrictions, and a potentially life-threatening disease poses significant challenge for individuals with syndromic Heritable Thoracic Aortic Disease (sHTAD). The primary aim of this study is to explore the interplay between chronic pain, f...

08/23/2025

2025 ADAMTS2: More than a procollagen N-proteinase

08/22/2025

2025 Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features