
10/04/2025
Today's Science Friday from Rx4Prevention: A new vaccine strategy to get ahead of coronaviruses
We’ve become accustomed to receiving annual influenza—and now COVID-19— vaccines developed to fight specific viral strains each autumn.
However, a new “Nature Communications” article highlights a different approach: broad-based vaccines that protect against a wide range of coronaviruses. These vaccines could be stockpiled and quickly deployed when a new virus emerges, shielding vulnerable groups early in the outbreak.
In discussing the strategy, the authors say this alternative approach would “buy valuable time” in a future pandemic—saving lives, easing the burden on health systems, and helping societies stay open—while scientists develop a vaccine to specifically target the new pathogen.
Using a mathematical model, the authors found a broadly protective vaccine has the potential to reduce deaths by more than 50 percent.
The team also applied their strategy to the recent COVID-19 pandemic to assess the potential impact of a broad-based vaccine. Estimates suggest up to 65% of COVID-19 deaths might have been prevented in the first year.