01/23/2026
Thank you for participating in Under the Scope with Octavius! 🔬🐙 This week's answer is...
Basophilic stippling! 🩸
Basophilic stippling refers to the presence of small, blue-purple granules scattered throughout the cytoplasm of red blood cells. These granules represent aggregates of ribosomal RNA and indicate abnormal or accelerated erythropoiesis. They may be evenly dispersed (fine stippling) or larger and irregular (coarse stippling).
Basophilic stippling is seen in a variety of conditions involving disordered hemoglobin synthesis, impaired RNA degradation, or toxic inhibition of enzymes, including lead poisoning, thalassemia, megaloblastic anemia, myelodysplastic syndromes, and severe hemolytic anemia.