01/05/2026
Low iron and “anemia” are often not true iron deficiencies - iron is abundant and accumulates - very high or low ferritin is more often a functional issue.
Many have asked about vitamin E and how it helps low ferritin. In short, it works by reducing iron toxicity and oxidative stress so the body can store iron safely again.
More specifically, Vitamin E reduces iron catalyzes lipid peroxidation—especially when PUFA is present. It quenches lipid peroxyl radicals, preventing iron from damaging cell membranes, which lowers the “need” to keep iron circulating defensively. So when oxidative stress falls, the body is more willing to store iron as ferritin.
Vitamin e may also indirectly raise ferritin to normal ranges by supporting ferritin synthesis. Ferritin is a stress-sensitive protein. High lipid peroxidation suppresses ferritin gene expression and keeps iron mobile instead of stored. Vitamin E normalizes redox signaling, allowing ferritin to be synthesized normally. This prevents ferritin degradation.
Additionally, there ir a strong relationship between thyroid, prolactin and ferritin. Vitamin E lowers prolactin and estrogen signaling - estrogen mobilizes iron into circulation and prolactin suppresses metabolic rate and iron handling. By antagonizing the effects of prolactin and estrogens you get better prolactin dopamine tone, better thyroid function and thus better iron utilization and storage.