23/11/2023
Similarities and differences
Let’s explore some of the similarities and differences concerning semaglutide vs tirzepatide as it pertains to weight loss:
Both medications work by limiting damaging postprandial glucose excursions (PPGEs) (aka blood sugar spikes)
Both medications work by balancing hormone levels which can be disrupted due to lifestyle, diet, and stress
Both medications increase adiponectin levels, which facilitates the further breakdown of fatty acids
Both medications reduce systemic inflammation
The only key difference between the two is that tirzepatide acts on both GIP and GLP-1 (although it binds more strongly to GIP receptors than GLP-1 receptors), whereas semaglutide only acts on GLP-1 receptors.
Finally, let’s get down to brass tacks: which one produces superior results? Here’s the side-by-side data:
In the clinical trials linked above, tirzepatide produced a 15% body weight reduction on average vs. semaglutide’s 14.9% average body weight reduction – nearly identical results
So, the bottom line is that the medications are virtually indistinguishable in terms of the weight loss results they deliver via the optimization of hormonal signaling.
