11/13/2025
Lyme disease represents one of the most complex biological interactions between a pathogen and its host.
Borrelia burgdorferi doesn’t simply invade — it influences multiple body systems, altering immune signaling, hormone regulation, and mitochondrial function.
This cascade affects how the nervous and endocrine systems communicate, disrupting neuroinflammation, stress response, and cellular energy production. The result is a wide range of symptoms — fatigue, pain, sleep disruption, cognitive changes — that vary dramatically from person to person.
Two individuals with identical exposure can have entirely different trajectories because their systems respond uniquely. Genetics, microbiome composition, toxin load, and baseline immune tone all shape the body’s resilience or vulnerability.
Understanding Lyme through a multi-system view of illness helps us move beyond the idea of a single-cause infection.
True recovery means addressing immune, hormonal, neurological, and metabolic systems together to restore balance and resilience throughout the body.