AxoSim

AxoSim empowers advancements in human neuroscience and accelerates the drug development

AxoSim’s NerveSim® and BrainSim® technology is revolutionizing drug development by offering the CRO industry’s most advanced, clinically-relevant models of neural tissue. The Company developed a 3D cell-based platform that looks and acts like a real nerve, serving as an alternative to costly animal testing and ineffective 2D models. AxoSim’s services provide pharmaceutical companies with high content data faster and earlier than currently possible. Currently, the Company uses its proprietary model to screening treatments for neurodegenerative diseases, such as multiple sclerosis and ALS, as well as advanced models for neurotoxicity testing.

07/29/2024

A little red (map2), white (dapi), and blue (gfap) to celebrate on this .

07/26/2024

Athletes are known for their strength and speed, but to compete at an elite level, their brains must connect with their bodies to enable precise motor function.

AxoSim wishes athletes across the globe a safe, meaningful, and victorious Olympics.

Pictured: Our creative take on the Olympic rings using immunofluorescent neurons of our brain organoids

07/25/2024

It was an honor to present yesterday at . If you missed the presentation or want to learn more about AxoSim, stop by our booth to see Megan Terral and Amit Johal.

07/01/2024

AxoSim's BrainSim® spheroids are differentiated for 84 days total. BrainSim® spheroids exhibit markers from neurons (MAP2), astrocytes (GFAP), and oligodendrocyte lineages (Olig2); major cellular components of the human brain.

06/25/2024

For those who weren't able to attend or would like more time to evaluate the data, we have made our posters from the MPS World Summit available on our website: https://buff.ly/3VXInUU

06/24/2024

Brightfield images of NerveSim® before (DIV43) and after (DIV50) dosing with 100 nM Vincristine. A dose range was performed, yielding quantifiable nerve fiber degeneration to produce an IC50 for the three image analysis metrics below.

Molecular Devices LLC

06/20/2024

Meet AxoSim in Montreal for the Peripheral Nerve Society annual meeting. Tyler Rodriguez, PhD will present on Monday at 5:30 PM (O 418).

06/17/2024

AxoSim's microBrain™ organoids can be used to simulate various neurodevelopmental and degenerative diseases. Here, we've grown organoids using iPSCs from a healthy donor (Control) and those of a patient with CDKL5 Deficiency Disorder (CDKL5 KO). While neurons (green) and astrocytes (magenta) develop normally, the CDD organoids show a dramatic hyperactivity phenotype that can be measured via high throughput calcium imaging.

06/11/2024

We are pleased to announce the appointment of Alif Saleh as AxoSim’s new chief executive officer. Founder and current CEO Lowry Curley, PhD, will step into the chief scientific officer role to lead all R&D efforts.

Read more about Alif's appointment and Lowry's new role: https://buff.ly/4aRbayw

06/07/2024

Join AxoSim scientist Corey Rountree for an oral presentation at MPS, "Human NerveSim® is a Peripheral Nerve Model for High-Throughput Functional Neurotoxicity and Neuroprotection Assays."

The presentation will take place on Friday, June 14, 2024, from 11:00 AM to 1:00 PM. Learn more: https://buff.ly/4dUx32J

06/06/2024

Next week at MPS, AxoSim scientist Nicholas Coungeris will present "Identification of a potential therapeutic compound for Rett syndrome using a highly homogenous human iPSC-derived cortical organoid screening platform." Stop by to see Nick at Poster #290 on Thursday, June 13, from 10:00 to 11:30 a.m.

Learn more: https://buff.ly/4dUx32J

06/05/2024

In one week, AxoSim scientist Lise Harbom will present "Modulation of glial differentiation in a 3D iPSC-derived CNS model" at MPS. Visit Lise at Poster #100 on Tuesday, June 11, 2024, from 4:30 PM to 6:00 PM.

Learn more: https://buff.ly/4dUx32J

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New Orleans, LA

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(504) 609-3469

Website

http://www.axosim.com/

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