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The Children's Hospital of Philadelphia Research Institute CHOP Research advances the health of children by turning scientific discovery into medical innovation
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Researchers at Children's Hospital of Philadelphia are studying how to generate cartilage implants for laryngotracheal r...
22/07/2025

Researchers at Children's Hospital of Philadelphia are studying how to generate cartilage implants for laryngotracheal reconstruction (LTR) less invasively than the current standard of care. LTR, which is a surgical procedure for patients with narrowed airways, involves enlarging the windpipe to make breathing easier. Building on previous LTR research, Dr. Riccardo Gottardi, leader of CHOP’s Bioengineering and Biomaterials lab, and his team are evaluating the potential for different cartilage cell types to provide the most sustainable results.

Learn more in a new Cornerstone story: http://ms.spr.ly/6189sDjsD

Before mastering the skills of business and budget sheets, CHOP Research Institute’s Director of Clinical Trials Financi...
21/07/2025

Before mastering the skills of business and budget sheets, CHOP Research Institute’s Director of Clinical Trials Financial Management (CTFM) Ray Goodridge was a Brooklyn child entranced by the sound and smells of race cars outside his window. Today, the CTFM leader still finds time to indulge his passion for drag racing by following the National Hot Rod Association U.S. Nationals each year, collecting fast cars, & going to professional races. Read more in our latest post:
http://ms.spr.ly/6183sDjDT

Children's Hospital of Philadelphia

18/07/2025

🎬 In our latest Lab Life episode, step into the research lab of Jennifer M. Kalish, PhD, Director of the Beckwith-Wiedemann Syndrome Program of Excellence at Children's Hospital of Philadelphia. Dr. Kalish and her team members share what it's like studying the role of genetic and epigenetic alterations in overgrowth syndromes, particularly Beckwith-Wiedemann syndrome. Watch the full video on our site now: http://ms.spr.ly/6184sBtsw

Congratulations to our Executive Vice President and Chief Scientific Officer, Dr. Susan Furth, on receiving the 2025 Cor...
16/07/2025

Congratulations to our Executive Vice President and Chief Scientific Officer, Dr. Susan Furth, on receiving the 2025 Corporate Leadership Award from the Philadelphia Business Journal.

Under Dr. Furth's leadership, Children's Hospital of Philadelphia Research Institute's 1,000+ principal investigators and their teams have developed many transformative translational research programs that are bringing much-needed solutions to children more quickly.

Learn more about Dr. Furth: http://ms.spr.ly/6184s6Qk6.

14/07/2025

We are incredibly grateful for the organizations - many of which are founded by patient families - who raise funds and awareness for pediatric research. In the second installment of our Power of Philanthropy podcast series, tune into a conversation between Children's Hospital of Philadelphia's Chief Scientific Officer Dr. Susan Furth and Dr. Laura Adang, an attending physician in the Division of Neurology whose research is grounded in years of collaboration with family-founded groups supporting research into leukodystrophies, a group of rare neurological disorders. Listen to the full episode now: http://ms.spr.ly/6189ShKuF

Children's Hospital of Philadelphia researchers developed a new screening tool to better understand how DNA methylation ...
10/07/2025

Children's Hospital of Philadelphia researchers developed a new screening tool to better understand how DNA methylation regulates gene expression and influences traits such as aging and disease risk. The tool “opens the door for exploring epigenetic mechanisms across tissues, aging, environmental exposures, and diverse populations,” according to Dr. Wanding Zhou, a computational scientist in CHOP’s Center for Computational and Genomic Medicine. Learn more in a new Snapshot Science blog post: http://ms.spr.ly/6186S7ycu

Did you know that baby KJ – the world’s first patient to receive a customized gene-editing therapy – began his breakthro...
10/07/2025

Did you know that baby KJ – the world’s first patient to receive a customized gene-editing therapy – began his breakthrough journey with a rapid genetic test developed and administered at Children's Hospital of Philadelphia?

CHOP’s Baby Eagle Initiative, established in 2023, is a fully in-house system for patients to receive rapid genome sequencing and analysis, often returning results in under a week. The Baby Eagle team swiftly diagnosed KJ with a rare genetic disorder a few days after his birth, and thanks to the quick diagnosis, researchers were able to develop a personalized gene therapy for the infant.

“KJ would not have had access to a test like this two years ago,” said Dr. Nancy Spinner, CHOP’s Chief of the Division of Genomic Diagnostics and a Baby Eagle team leader. “His diagnosis and subsequent treatment are the result of CHOP Research Institute’s investment in science, cutting-edge technology, and multidisciplinary team building.”

In a new Cornerstone story, dive deeper into Baby Eagle and how it transforms the lives of our patients: http://ms.spr.ly/6182S7HKu

😎 Summer is well under way and so are these undergraduate students who are spending their breaks learning how to make th...
10/07/2025

😎 Summer is well under way and so are these undergraduate students who are spending their breaks learning how to make the world a safer place! Meet the 2025 cohort of the Injury Science Research Experiences for Undergraduates (REU) program - a 10-week paid internship hosted by our Center for Injury Research and Prevention at CHOP! Last week, REU interns completed week 5 of the dynamic program that includes mentorship from CIRP's stellar faculty and staff + hands-on research experience in engineering, behavioral science, education, population science, and statistics. Learn more about the program: http://ms.spr.ly/6188S7Gy6

Our researchers at Children's Hospital of Philadelphia uncovered an electrophysiological phenomenon that could explain t...
30/06/2025

Our researchers at Children's Hospital of Philadelphia uncovered an electrophysiological phenomenon that could explain the clinical effects of electroconvulsive therapy (ECT), an intervention that delivers brief electrical pulses to the brain, as treatment for severe depression. The discovery advances our understanding of ECT's mechanisms and could guide researchers toward developing more personalized ECT therapies in the future. Learn more in a new Snapshot Science blog post: http://ms.spr.ly/6187SFXmd

How do you reset and recharge? For Dr. Valentina Graci, a research scientist in our Center for Injury Research and Preve...
25/06/2025

How do you reset and recharge? For Dr. Valentina Graci, a research scientist in our Center for Injury Research and Prevention at CHOP, recharging looks like donning a wetsuit and volunteering as a scuba diver for a local aquarium. In our latest story, Dr. Graci shares how she shifts from the demands of life in the lab to nurturing a love for being in the water.

“I’m in a completely different environment with different restrictions and different demanding tasks,” Dr. Graci said. “I put aside all my work problems because I have to be focused on how much air I have left or what I have to clean. It is like meditation. It’s something I absolutely need.”

Read the full story now: http://ms.spr.ly/6185SxJJS

Dr. Audrey Odom John, Chief of the Division of Infectious Diseases at Children's Hospital of Philadelphia, and her team ...
23/06/2025

Dr. Audrey Odom John, Chief of the Division of Infectious Diseases at Children's Hospital of Philadelphia, and her team received funding from the Gates Foundation to collect and refine breath volatile biomarkers when screening for . In a new Cornerstone story, learn how the grant brings the researchers closer to advancing the development of a 'malaria breathalyzer' that will detect the malaria-causing parasite in asymptomatic patients and help reduce malaria transmission. http://ms.spr.ly/6181Sxy1L

What do traffic jams and the cellular processes in our DNA have in common? Find out in a new Cornerstone story featuring...
20/06/2025

What do traffic jams and the cellular processes in our DNA have in common? Find out in a new Cornerstone story featuring Dr. Priya Sivaramakrishnan, a Children's Hospital of Philadelphia researcher who is one of 10 scientists recognized with a Beckman Young Investigator (BYI) Award from the Beckman Foundation! With funding over the course of four years, Dr. Sivaramakrishnan will elucidate her research project titled “The Choice Between RNA and DNA: Navigating Traffic Jams During Embryonic Cell Fate Programming”. Read the full story now: http://ms.spr.ly/6181SQGFv

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