The Children's Hospital of Philadelphia Research Institute

The Children's Hospital of Philadelphia Research Institute CHOP Research advances the health of children by turning scientific discovery into medical innovation
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03/11/2026

Dr. Jami Young, Associate Chair of Research in the Department of Child and Adolescent Psychiatry and Behavioral Sciences at Children's Hospital of Philadelphia, shares why primary care is a critical access point for detection and early intervention of and su***de risk. Read more about this and other best practices CHOP investigators shared in the last year in our 2025 Research Annual Report: http://ms.spr.ly/6183QcvEF

With the support of Dr. Jordan Orange, Children's Hospital of Philadelphia's Chair of the Department of Pediatrics, worl...
03/10/2026

With the support of Dr. Jordan Orange, Children's Hospital of Philadelphia's Chair of the Department of Pediatrics, world-renowned immunologist, and At-Large Director on the American Academy of Allergy, Asthma, and Immunology's (AAAAI) Board of Directors, high school students in our CHOP-RISES summer internship programs attended a very special event last week: the AAAAI's Annual meeting! The event enriched an already incredible internship experience for the students as they explore careers in science and health.

"Supporting the future of our community is a priority at CHOP and in helping advance the flourishing of Philadelphia’s youth," Dr. Jordan said. "This collaboration with the AAAAI, which I am proud to be a part of, represents a partnership with important opportunity created by an organization visiting our city to be able to benefit the growth of its emerging scholars. I hope many national organizations visiting Philadelphia will choose to do the same moving forward."

Learn more about CHOP-RISES, a two-summer STEM-M internship that empowers local public and charter high school students in to explore and pursue careers in science and health: http://ms.spr.ly/6180QcQau

Opioid use in pregnancy and postpartum increased 131% between 2010 and 2017, according to the Center for Disease Control...
03/10/2026

Opioid use in pregnancy and postpartum increased 131% between 2010 and 2017, according to the Center for Disease Control and Prevention. A range of adverse outcomes for both mother and baby are associated with this use, including maternal morbidity, neonatal opioid withdrawal syndrome, preterm birth, restricted fetal growth, and stillbirth. Researchers in Children's Hospital of Philadelphia’s PolicyLab and Qualitative Research Core highlighted how substance use disorder care for pregnant and postpartum people is different from other populations.

Their research methods focused on the stories of pregnant and parenting people, prenatal care providers, treatment centers, and county-level administrators across Pennsylvania. Learn more in a new Snapshot Science story: http://ms.spr.ly/6189QcSmv

The National Institutes of Health recognized last week. KJ Muldoon, the first patient to receive a personalized gene t...
03/02/2026

The National Institutes of Health recognized last week. KJ Muldoon, the first patient to receive a personalized gene therapy, along with his mom and doctors, participated in a panel discussion at the NIH 😍 KJ was diagnosed with a rare urea cycle disorder last year via a Rapid Targeted Analysis of the Genome-Infant (rTAG-I) test developed by researchers in CHOP’s Baby Eagle Initiative to identify rare diseases.

Read more about how the CHOP-Penn team that developed his customized treatment look to make the precision medicine approach accessible for many more patients: http://ms.spr.ly/6180QdUGr

Our Clinical In Vivo Gene Therapy (CIGT) team hosted a lunch this week and showed their support for rare disease resea...
02/28/2026

Our Clinical In Vivo Gene Therapy (CIGT) team hosted a lunch this week and showed their support for rare disease research by wearing stripes.

Led by in vivo gene therapy experts with more than 10 years of clinical trial experience, our CIGT team develops and conducts adeno-associated virus gene transfer and molecular therapy trials at CHOP. Learn more about the CIGT: http://ms.spr.ly/6184QjKkj

02/27/2026

In this video, Drs. David Teachey and Stephen Hunger, investigators at the Cancer Center at CHOP, talk about a 2025 New England Journal of Medicine study that "changes the way that we treat children with leukemia across the globe". Following the results of a Phase 3 clinical trial co-led by Drs. Teachey and Hunger, most children in the United States newly diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) can now receive an immunotherapy called blinatumomab as part of their standard treatment. Learn more in our Research Annual Report: http://ms.spr.ly/6185QbxeT

One year after baby KJ Muldoon became the first patient to receive a personalized gene therapy for his rare urea cycle d...
02/26/2026

One year after baby KJ Muldoon became the first patient to receive a personalized gene therapy for his rare urea cycle disorder, the researchers at Children's Hospital of Philadelphia and University of Pennsylvania who developed the customized treatment are working toward making the precision medicine approach accessible for more patients. Learn how Dr. Rebecca Ahrens-Nicklas, Director of the Gene Therapy for Inherited Metabolic Disorders Frontier Program (GTIMD) at CHOP, and her team aim to create a scalable pathway for the development of personalized gene therapies, in a new Cornerstone story: http://ms.spr.ly/6180Qbyni

02/17/2026

In this short video from our 2025 Research Annual Report, Dr. Audrey Odom John, Chief of the Division of Infectious Diseases at Children's Hospital of Philadelphia, shares why she is excited about developing a noninvasive breath test that could help detect malaria. Learn more in the full story: http://ms.spr.ly/6183Qp7Xl

A new training program at Children's Hospital of Philadelphia invites early career investigators to learn how their rese...
02/12/2026

A new training program at Children's Hospital of Philadelphia invites early career investigators to learn how their research studies could better support individuals with Down syndrome. Read about the Program to Advance Research and Transdisciplinary TraiNing in the Care of PeRsons with Down Syndrome (PARTNERS) and how it cultivates a generation of collaborative investigators with expertise on working in clinical research settings with individuals with ability differences: http://ms.spr.ly/6183QRMCP

Our February featured monthly Faculty Spotlight is Dr. Robert Potter, microbiologist and faculty member in CHOP’s Depart...
02/12/2026

Our February featured monthly Faculty Spotlight is Dr. Robert Potter, microbiologist and faculty member in CHOP’s Department of Pathology and Laboratory Medicine. Dr. Potter studies clinical microbiology, next-generation sequencing, and phenotypic assays to enhance patient health outcomes. He shares more about his research and ways investigators can seek funding for their work, in a new Q&A: http://ms.spr.ly/6186QRyRI

02/11/2026

Thank you to our amazing Office of Research Safety at CHOP Research Institute for hosting another fun, informative, and productive Safety Day! Safety in the lab is the foundation for the discoveries we make and the lives we transform through pediatric research ❤️ This annual event, which included an admin expo, vendor booths, games, and prizes, always brings our community together to raise awareness of the shared responsibility that is research safety.

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