Treating Corticobasal Syndrome - CBS

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This is Us

I’m Chavonne Sladek, and I’m Don Sladek’s wife. Don is a Vietnam Era Veteran who was stationed in Southeast Asia and proudly served his country. He was also employed at Edwards Air Force Base's Rocket Propulsion Laboratory in the area of research and development. We are not scientists, doctors, or researchers; we are just regular people dealing with a terminal diagnosis called Corticobasal Syndrome (CBS). We are usually a private couple, but we are now compelled to share our unique story.

Don participated in a Phase I Clinical Trial called the TauBasket. He was given an infusion every 28 days. The medication that he was given was manufactured by Biogen, and called BIIB092, Gosuranemab. The positive changes in Don were remarkable and all clinically verified through the University of California, San Francisco, and the University of California, Los Angeles.

Biogen was using their medication BIIB092, Gosuranemab, in three concurrent clinical trials. Their goal is to manufacture a drug that will help Alzheimer’s patients: that is their money maker and where they will reap billions of dollars on the open market, and recoup the cost of trials. Unfortunately Alzheimer’s is hard to unlock.

For many years, amyloid plaques were seen to be the cause of Alzheimer’s and all research was focused on that. Currently, the research focus has shifted to tau tangles, but it is hard to isolate that in Alzheimer’s. There are two diseases that are believed to be a straight tauopathy. Progressive Supranuclear Palsy (PSP) is rare, but has a significant population where you could test different drugs, and Don’s disease, Corticobasal Syndrome (CBS) which is much rarer.

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