Center for Innovative Phage Applications and Therapeutics

Phage therapy: From biological mechanisms to future directions

Today, I published a review paper in the journal Cell with colleagues Chip Schooley, Graham Hatfull & Vivek Mutalik. Given that some of the research we discussed was directly influenced by our experiences with Tom's case and others that followed (such as Mallory Smith, Isabelle Carnell Holdaway, John Wilson, John Haverty and Greg Breed), I feel very proud. Together, we are moving the needle. PHAGE ON!

Phage therapy: From biological mechanisms to future directions Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years…

NIH-supported clinical trial of phage therapy for cystic fibrosis begins

It's finally happening! So excited to see NIAID's first phage therapy trial launched to treat multi-drug resistant bacterial infections in cystic fibrosis patients under the leadership of Robert Schooley at IPATH through the Antimicrobial Resistance Leadership Group in collaboration with Walter Reed, Adaptive Phage Therapeutics. Special thanks to the Mallory Smith Legacy Fund for additional funding at IPATH. It's especially gratifying to see the quote from Tony Fauci in this press release.

NIH-supported clinical trial of phage therapy for cystic fibrosis begins The trial is evaluating whether the bacteriophage therapy is safe and able to reduce the amount of bacteria in the lungs of volunteers.

Viruses to Fight Superbugs? Scientists Are Working on It

https://www.wired.com/story/phage-viruses-fighting-drug-resistant-bacteria/

Viruses to Fight Superbugs? Scientists Are Working on It Phages may help fight drug-resistant infections—but finding the right ones for each bacterium is no mean feat.

Phage Therapy: Past, Present and Future | ASM.org

https://asm.org/Articles/2022/August/Phage-Therapy-Past,-Present-and-Future

Phage Therapy: Past, Present and Future | ASM.org The use of phage therapy to treat bacterial infections has largely existed on the fringes of medicine in the U.S. Why? And what needs to happen to make phage therapy mainstream?

Ny metod: Bakterieätande virus används för att behandla infektioner

Sweden now has a phage therapy program in Uppsala. https://www.svt.se/nyheter/lokalt/uppsala/akademiska-forst-i-landet-med-ny-behandling-av-protesinfektioner

Ny metod: Bakterieätande virus används för att behandla infektioner På Akademiska har man som första sjukhus i landet provat en ny behandling av infekterade ledproteser – en komplikation som kan uppstå efter en knä- eller höftledsoperation. Nu hoppas läkarna att den nya metoden ska ersätta komplicerade operationer och månaders antibiotikabehandling. – De...

Novel Insights into Jumbo Phages and Their Defenses against Bacteria

Awesome new research from UCSD colleagues that has the potential to make phage therapy even better by capitalizing upon the ability of some phage to make giant compartments to keep their genetic material safe from enemy bacteria.

https://www.genengnews.com/news/novel-insights-into-jumbo-phages-and-their-defenses-against-bacteria/

Novel Insights into Jumbo Phages and Their Defenses against Bacteria A group of researchers report new insights into previously unrecognized phage biological structures and processes.

Meet the scientist who used a bacteria-fighting virus to save her husband when nothing else worked

Meet the scientist who used a bacteria-fighting virus to save her husband when nothing else worked Her story is one that might save countless lives from the increasing threat of antibiotic-resistant superbugs.

IPATH's Drs Schooley and Strathdee on the potential of phage therapy to treat superbug infections.

https://www.healio.com/news/infectious-disease/20220516/rediscovering-phages-we-finally-have-the-tools-to-harness-them

A Guide to Decentralized Biotech

A Guide to Decentralized Biotech Shared lab space, DAO-funded projects, and other signs of big structural change in a traditionally centralized industry.

Dr. Steffanie Strathdee: Stigma and why phage therapy was forgotten - Everybody Hates Me: Let's Talk About Stigma

Phage therapy was 'forgotten' in the West for 100 years. Find out why in this podcast!

Dr. Steffanie Strathdee: Stigma and why phage therapy was forgotten - Everybody Hates Me: Let's Talk About Stigma Dr. Steffanie Strathdee is Associate Dean of Global Health Sciences and Harold Simon Distinguished Professor in the Department of Medicine at the University of California San Diego School of Medicine. She co-directs UCSD’s new center for Innovativ...

French Hospital Starts Program to Fight Antibiotic Resistance

France embraces phage therapy!

https://www.medscape.com/viewarticle/972140?fbclid=IwAR1T2CWX0SaKhVsGIzNdV-RQAPx_ZQgZ1ivNduWzTylmC0lt3J_8FZCVErY

French Hospital Starts Program to Fight Antibiotic Resistance To address the growing problem of antibiotic resistance, researchers are turning to bacteriophages, which kill bacteria effectively without affecting human cells.

Considerations for the Use of Phage Therapy in Clinical Practice | Antimicrobial Agents and Chemotherapy

Congrats to IPATH's Saima Aslam and David Pride for this seminal paper on guidelines for phage therapy in clinical practice.

https://journals.asm.org/doi/10.1128/AAC.02071-21

Considerations for the Use of Phage Therapy in Clinical Practice | Antimicrobial Agents and Chemotherapy Increasing antimicrobial resistance and medical device-related infections have led to a renewed interest in phage therapy as an alternative or adjunct to conventional antimicrobials. Expanded access and compassionate use cases have risen exponentially but ...

Salt In My Soul: Poignant Film Calls Attention To The Need For Phages For Antibiotic Resistance

A must watch film on the life of Mallory Smith, a young woman who strove to 'live happy' despite battling CF and a deadly superbug infection.

https://www.forbes.com/sites/judystone/2022/01/22/salt-in-my-soul-poignant-film-calls-attention-to-the-need-for-phages-for-antibiotic-resistance/?sh=28e8e2547592

Salt In My Soul: Poignant Film Calls Attention To The Need For Phages For Antibiotic Resistance Phage therapy could save many lives. Hopefully, sharing Mallory Smith's story will boost research into cystic fibrosis, growing antibiotic resistance, and the promise of phages.

Many of you will remember Mallory Smith, one of the earliest patients we tried to save but didn't make it in time. Her parents believe that phage therapy could have saved her life and since then have advocated fearlessly, generated hundreds of thousands of dollars to support phage therapy research, and published Mal's memoir, Salt in My Soul. The documentary based on her story is coming soon! Don't miss it!

Timeline photos

Books, Booze, and Authors! 📕 - https://mailchi.mp/sciencemarchind/perfect-predator

Can viruses save lives? | Science Journal for Kids and Teens

Can viruses save lives? | Science Journal for Kids and Teens Researchers reviewed scientific articles and case reports to evaluate phage therapy as an alternative to antibiotics and found this can be beneficial for patients. Scientific article for students.

Tom and I are thrilled that our story was featured in this amazing documentary, along with the one and only Dr. Chip Schooley! It's great to see it recognized as a Cannes official selection!

We're proud to announce that BEATING SUPERBUGS: CAN WE WIN? is now a Cannes World Film Festival Official Selection for their current monthly competition.

Center for Innovative Phage Applications and Therapeutics updated their website address.

Center for Innovative Phage Applications and Therapeutics updated their website address.

Q&A Steff Strathdee author “The Perfect Predator” - Phage Club

Q&A Steff Strathdee author “The Perfect Predator” - Phage Club Friday, March 26 at 1:00pm CDT with Dr. Sabrina Green PhD, Adriana C Hernandez PhD. (RECORDED)Phage Phridays special guest is Dr. Steffanie Strathdee author of “The Perfect Predator”

We are excited to announce the premiere of the documentary, BEATING SUPERBUGS: CAN WE WIN?, which features IPATH's very own Co-Directors, Drs. Steffanie Strathdee and Robert Schooley.

Date: Thursday, February 11, 2021
Time: 4:30 PM -6:30 PM, PST (and coast to coast at the same hour in your time zone)
Location: Zoom
Cost: Free event
Registration required (maximum of 1,000 registrants)

You can register at the below link: https://ucsd.zoom.us/webinar/register/WN_IlE0NiP5QhKoXYHFfSrxsg

Why the truth is sometimes more terrifying than fiction

Why the truth is sometimes more terrifying than fiction The Perfect Predator warns against the coming catastrophe of a post-antibiotic era and proves more frightening than fictional thrillers The Silence by Don DeLillo and The Russian Pink by Matthew Hart.

The Actinobacteriophage Database | Phage Strathdee

A dream come true thx to students at the University of Ottawa...I have a phage named after me! I'm so jazzed!

The Actinobacteriophage Database | Phage Strathdee

Kidney Transplant Patient Turns a Phage

Learn how IPATH's Dr Saima Aslam helped cure Madrigal from her superbug infection (Spanish w/ English subtitles)

Kidney Transplant Patient Turns a Phage Maria Madrigal was born with a kidney disease that ultimately required removal of both organs, and a new donor kidney. But before and after the transplant, s...

While the world is gripped by COVID-19, another devastating health threat is building — this one from bacteria

While the world is gripped by COVID-19, another devastating health threat is building — this one from bacteria Diseases caused by bacteria already kill 700,000 people every year. The threat is slowly growing, with few ways to stop it.

Viruses, lords of creation—exploring the little-known viral universe

Viruses, lords of creation—exploring the little-known viral universe Our podcast on the science and technology making the news. Also this week: how viruses shape human development and how to combat viral threats

Women In Bio

Women In Bio YWIB and its partners are offering three Experiential Learning Sessions this summer! Come and Chat with STEM Influencers, while learning and making your own STEM-inspired jewelry designs. This event is for all skill levels - if you have not studied STEM before, come join us and learn; if you are use...

Help Us Win the War on Superbugs

Ten days left to help support IPATH!

https://crowdsurf.ucsd.edu/project/21390?fbclid=IwAR20iRShV1QX3XfHNpRDBuMxQWrgQzDjBLDl50CTNEUVGkmUjyXqU97x_78

Help Us Win the War on Superbugs Help UC San Diego raise $10,000 for the project: Help Us Win the War on Superbugs. Your gift will make a difference!

Sharing a photo of IPATH's littlest caregiver who made some phage art to cheer her Grammy who started receiving phage therapy yesterday! Go phages go!

Delighted to see IPATH mentioned in Nature discussing phage therapy to treat superbugs associated with cystic fibrosis!

Phage therapy shows potential for treating prosthetic joint infections

Congrats to the Mayo Clinic for the publication of their first successful treatment of a superbug infection with phage therapy. Check out the video featuring the patient, John Haverty!

Phage therapy shows potential for treating prosthetic joint infections ROCHESTER, Minn. — Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according [...]

Help Us Win the War on Superbugs

Did you know that the COVID19 pandemic is making the superbug crisis even worse? IPATH is the 1st dedicated phage therapy center in N.America based at UCSD & we are crowdfunding so we can help more superbug patients. Please consider donating. Every little bit helps!

Help Us Win the War on Superbugs Help UC San Diego raise $10,000 for the project: Help Us Win the War on Superbugs. Your gift will make a difference!