09/29/2023
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648126/
"Allergies are chronic inflammatory disorders involving various immune cells such as mast cells, eosinophils, and T lymphocytes. IgG4 was also found to be higher in patients with AR, asthma, and AD than in non-allergic subjects and had a positive correlation to allergic diseases."
IgG4 is a subclass of IgG antibody with a unique molecular feature of (Fragment antigen- binding) Fab-arm exchange, allowing bispecific antigen binding in a mono-valent manner. With low binding affinity to C1q and Fcγreceptors, IgG4 is incapable ...