01/10/2026
Psoriasis is often treated as a skin-limited condition, but global data suggest a broader and growing challenge.
Using Global Burden of Disease estimates and time-series modeling, this analysis projects a continued rise in psoriasis incidence through 2050, with meaningful differences by age, s*x, and region.
A higher burden was observed in higher-SDI regions, and incidence increased more sharply with age in men.
In functional medicine, we rarely view skin in isolation. Skin health is deeply connected to the gut, and the gut is shaped by diet, environment, and immune signaling. While this study does not examine mechanisms, it raises important questions about how modern exposures may influence chronic inflammatory skin disease at the population level.
These findings are descriptive, not causal, but they highlight why a systems-based lens matters when we think about long-term disease trajectories.
Source: doi: 10.1001/jamadermatol.2025.4572
