Nancy's Nutrition Inc

05/01/2026

04/30/2026

04/30/2026

If you have both MTHFR variants and histamine intolerance, you are likely not managing two separate conditions. You are managing one underlying issue with two expressions.

Your body has two main pathways for clearing histamine. The first is DAO (diamine oxidase), an enzyme in the gut lining that breaks down histamine from food. The second is HNMT, which works inside cells to clear systemic histamine and depends directly on methylation to function.

When MTHFR is struggling, the methylation cycle runs below capacity. That puts HNMT under strain. All the pressure then falls on DAO alone.

DAO is already compromised in many people by leaky gut, SIBO, alcohol, certain medications, and low copper or B6 levels. Asking it to handle the full histamine load by itself is rarely sustainable.

Addressing histamine without supporting methylation is treating the surface and leaving the root in place.

The most direct action you can take is supporting the DAO enzyme directly. DAO supplementation supports healthy breakdown of histamine in the gut before it enters circulation, givingbuying your body time while you address the underlying methylation needsdeficit. Supporting cofactors like B6, copper, and zinc gives both pathways nourishment to function well.*

Comment HISTA below and we will send you our number one recommendation for DAO and histamine support.*

04/30/2026

What exactly is a digestive enzyme?

It’s a question I’ve been asked many times over the years.

Put simply:

👉 Enzymes are what break your food down

Every time you eat, your body relies on enzymes to convert food into smaller, usable nutrients.

For example:
• Proteases → break down protein
• Lipase → breaks down fats
• Amylase and related enzymes → break down carbohydrates

Without enough enzyme activity:

👉 Food isn’t fully broken down

And when that happens:

• It can sit in the gut longer
• It may ferment
• Gas and bloating can increase
• Nutrient absorption may be reduced

In my clinical experience, many digestive issues don’t come down to what people are eating…

👉 But how well they are digesting it

This is why enzyme function is such an important — and often overlooked — part of gut health.

Because digestion isn’t just about diet…

👉 It’s about what your body can actually break down and use.