AlphaJoeCoffee

18/06/2025

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I cover the facts about hydrolyzed whey few are aware of. Does it have benefits over regular whey? If so, for who and why? Is it superior for bodybuilders an...

22/05/2025

As creatine is generally neuro protective, and has benefits in some neuro muscular diseases, and so forth, no surprises here. More data needed, but very promising:

New creatine study suggesting promise with AD! That's a potentially important finding:

"Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition”

Highlights

Creatine monohydrate supplementation was feasible in patients with Alzheimer's disease.

Creatine monohydrate was associated with increased brain total creatine.

Creatine monohydrate was associated with improvements in cognition.

Efficacy of creatine monohydrate in Alzheimer's disease should be studied further.

Abstract

BACKGROUND

Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the effects of CrM in patients with AD.

METHODS

In this single-arm pilot trial, we investigated the feasibility of 20 g/day CrM for 8 weeks in 20 patients with AD. We measured compliance throughout; serum creatine at baseline, 4 weeks, and 8 weeks; and brain total creatine (tCr) and cognition (National Institutes of Health [NIH] Toolbox, Mini-Mental State Examination [MMSE]) at baseline and 8 weeks.

RESULTS

Nineteen participants achieved the target of ≥80% compliance with the CrM intervention. Serum Cr was elevated at 4 and 8 weeks (p < .001) and brain tCr increased by 11% (p < .001). Cognition improved on global (p = .02) and fluid (p = .004) composites, List Sorting (p = .001), Oral Reading (p < .001), and Flanker (p = .05) tests.

DISCUSSION

Our data suggest that CrM supplementation is feasible in AD and provides preliminary evidence for future efficacy and mechanism studies.

BACKGROUND Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer's disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the ...

25/04/2025

Creatine is a widely used ergogenic aid that enhances muscle strength and lean mass. However, concerns have been raised about the potential role in promoting hair loss by increasing dihydrotestoste...

11/04/2025

More creatine win!

Creatine has been reported as one of the most commonly used dietary sports supplements, yet the latest research suggests that its benefits may extend far beyond athletic performance and muscle recovery.

31/03/2025

Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

24/02/2025

Chocolate/Cocoa News! 😎

Another study finds vascular benefits of cocoa ingestion:

"The Effect of Dark Chocolate Consumption on Arterial Function in Endurance Male Runners: Prospective Cohort Study"
Sports (Basel) 2024 Dec 13;12(12):344.

Abstract
Foods rich in polyphenols have beneficial effects on health. This study aimed to examine the impact of dark chocolate on endurance runners’ arterial function. Forty-six male amateur runners, aged 25–55, participated. The initial assessments included clinical testing, arterial stiffness measurements, and a cardiopulmonary exercise test. The participants then consumed 50 g of dark chocolate (70% cocoa) daily for two weeks, maintaining their usual training routine. After this period, the baseline assessment was repeated. The results showed significant improvements. Pulse wave velocity decreased by 11.82% (p < 0.001), and augmentation index by 19.47% (p < 0.001). Systolic brachial blood pressure reduced by 2.12% (p < 0.05), diastolic by 2.79% (p < 0.05), and mean pressure by 2.41% (p < 0.05). Central arterial pressure also decreased, with systolic by 1.24% (p < 0.05), diastolic by 2.80% (p < 0.05), and mean pressure by 2.43% (p < 0.05). Resting heart rate increased by 4.57% (p < 0.05) and left ventricular ejection time decreased by 4.89% (p < 0.05), particularly in athletes over 40. Exercise time increased by 2.16% (p < 0.05), heart rate (max) by 1.15% (p < 0.05), VO2max by 2.31% (p < 0.05), and anaerobic threshold shifted by 6.91% (p < 0.001) in exercise time and 6.93% (p < 0.001) in VO2max. In conclusion, dark chocolate improves arterial function in endurance runners, enhancing vascular health.
Keywords: polyphenols, dark chocolate, vascular function, arterial stiffness, endurance runners

https://pmc.ncbi.nlm.nih.gov/articles/PMC11679228/

Foods rich in polyphenols have beneficial effects on health. This study aimed to examine the impact of dark chocolate on endurance runners’ arterial function. Forty-six male amateur runners, aged 25–55, participated. The initial assessments included ...

12/02/2025

Will Brink, February 12, 2025February 12, 2025, Bomb-Proof Coffee, General Health, Supplement Science, 6 2025 Updates: Data continues to support the fact creatine is far more than a simple sports nutrition supplement per studies below, which I have updated several times. Yet another study supporting...

04/02/2025

Alpha Joe users, creatine may augment the effects of therapy, which supports prior data supporting Cr as mood booster and brain function:

"Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area"
European Neuropsychopharmacology

Volume 90, January 2025, Pages 28-35

Highlights

•Creatine is an inexpensive compound that can augment antidepressants’ effects.
•Creatine appears better than placebo in increasing the antidepressant efficacy of CBT.
•Creatine is as safe and well-tolerated as placebo in depressed participants at 8 weeks.
•Longer and adequately sized trials of creatine in depression are warranted.

Abstract

Pre-clinical and clinical evidence proposes that creatine monohydrate, an affordable nutraceutical, could be a useful adjunct to conventional antidepressant treatments. In this pilot feasibility and exploratory study, we investigate the 8-week effects of creatine in addition to cognitive-behavioural therapy (CBT) versus placebo plus CBT in depression. For the primary efficacy outcome of change in Patient Health Questionnaire-9 depression score at study endpoint, we used mixed-model repeated measures analysis of covariance. Logistic regressions were employed to assess acceptability (any-cause dropouts), tolerability (dropouts for adverse events), and safety (patients experiencing one or more adverse events). We calculated effect sizes adjusted for age, s*x, and baseline depression score. One-hundred participants (50 females, mean age= 30.4 ± 7.4 years) with depression (mean PHQ-9 = 17.6 ± 6.3) were randomised to either creatine+CBT (N = 50) or placebo+CBT (N = 50). At 8 weeks, PHQ-9 scores were lower in both study arms, but significantly more so in participants taking creatine (mean difference= -5.12). Treatment discontinuations due to any cause and to adverse events, and proportion of participants with at least one adverse event were comparable between study arms. This hypothesis-generating trial suggests that creatine could be a useful and safe supplement to CBT for depression. Longer and larger clinical trials are warranted.

Pre-clinical and clinical evidence proposes that creatine monohydrate, an affordable nutraceutical, could be a useful adjunct to conventional antidepr…

28/10/2024

Via Nutrition Made Simple. That's one YT channel I recommend for balanced evidence based information, so comes under "BrinkZone Approved" 😎

https://www.youtube.com/watch?v=EE3QMhS6FHw

Coffee can affect your metabolism, risk of diabetes, brain function & even cancer. Find out howConnect with me:Facebook: https://www.facebook.com/DrGilCarval...

19/10/2024

The coffee maker slows down if you stare at it.

17/10/2024

FREE SEMINAR (You Missed) 😎😉💪

For those who were unable to attend my first Alpha Joe/BrinkZone seminar:

•I covered the changes coming to AlphaJoeCoffee
•A new whey protein based product that will be available soon. More details to come!
•The difficulties in obtaining German (Creapure) creatine for Alpha Joe.
•The difficulties in obtaining the grade of whey I plan to offer in the new product.
•Answered a variety of Qs attendees had regarding the above, as well as others!

The plan is to offer the free seminar and casual discussion to select people on my lists monthly. If you want to attend, join the mailing list at my site (www.BrinkZone.com) or purchase some AlphaJoe!

I may move it to another day and time as feedback comes in. From those who attended the first one, feedback was great!

02/10/2024

🔍 Can L-Tyrosine "Help Elevate Your Mental Performance”?

L-Tyrosine (one of the core ingredients in our AlphaJoe Coffee Booster) isn't just any amino acid; it's a supplement that data from many studies demonstrate may help increase neurotransmitters responsible for your mental alertness, concentration, and mood, and one of the supplements often used by elite military forces.

Here’s how L-Tyrosine enriches your AlphaJoe experience:

- Research indicates it may boost cognitive function: L-Tyrosine can help support memory and decision-making processes under stress or fatigue.

- It can enhance mental clarity and help cut through the fog, giving you clear-headedness for those demanding days.

- It can also improve stress response by helping synthesize neurotransmitters like dopamine and norepinephrine; L-Tyrosine can help you stay calm and focused under pressure.

Want to know more?

Incorporating L-Tyrosine into your daily routine is as easy as enjoying your morning cup by simply adding AlphaJoe.

👉 “Elevate Your Coffee, Elevate Your Mind: With AlphaJoe Coffee Booster,” Discover how each ingredient in AlphaJoe Coffee Booster is selected for its unique benefits, just like L-Tyrosine at BoostYourCoffee.com