05/10/2022
Approximately 12% of the population (children and adults) experience painful and debilitating migraines. Migraines are complex and their exact cause and trigger are not known. Inflammation in the nervous system (neurogenic inflammation), dilation of blood vessels on the surface of the brain, and alterations in neurochemicals and neuropeptides (serotonin, nitric oxide, endothelin, CGRP) are some of the abnormal brain activities associated with migraines.
A recent review article concluded that lavender, peppermint, German chamomile, anise, basil CT estragole, rose, and garlic essential oils were useful for migraines. They further identified constituents in these oils that contribute to relief of factors that contribute to migraines: menthol (pain relief, reduces neurogenic inflammation); borneol (relaxes blood vessels, reduces neurogenic inflammation); 1,8-cineole (dilates blood vessels, reduces neurogenic inflammation, inhibits CNS pain); linalool/linalyl acetate (reduces neurogenic inflammation, inhibits CNS pain); menthone (reduces neurogenic inflammation); limonene (pain relief, reduces neurogenic inflammation, balances vasomotor abnormalities); alpha-pinene (reduces neurogenic inflammation); beta-elemene (reduces neurogenic inflammation); beta-caryophyllene (reduces neurogenic inflammation, balances vasomotor abnormalities); trans-anethole (reduces neurogenic inflammation, balances vasomotor abnormalities); diallyl trisulfide (reduces neurogenic inflammation); estragole (reduces neurogenic inflammation, balances vasomotor abnormalities); and citronellol (relaxes blood vessels, reduces neurogenic inflammation, reduces excess pain response).
https://www.sciencedirect.com/science/article/pii/S0378874120332086
Based on the oils and the mechanisms by which the constituents work, create a blend in a 10 mL roller bottle using the oils in the image.