08/18/2025
As weight management and diabetes control remain hot topics in the healthcare industry, two medications—semaglutide and tirzepatide—have taken center stage. Though they differ in several important ways, both medications have proven effective for weight loss. Healthcare providers now commonly use them to help treat patients with Type 2 diabetes.
Commonly known by brand names Ozempic, Wegovy, and Rybelsus, semaglutide is a GLP-1 receptor agonist. When injected, it mimics a naturally occurring hormone called glucagon-like peptide-1 (GLP-1) that stimulates insulin production.
Patients and physicians have had significant success using semaglutide to:
Regulate appetite and calorie intake
Reduce cravings
Slow down digestion (making you feel fuller longer)
Control your liver’s sugar production
Support weight loss
Improving blood sugar levels
Lessening the reliance on insulin
Newer to the market, tirzepatide (branded as Mounjaro and ZepBound) also mimics the GLP-1 hormone. But it also imitates another hormone called gastric inhibitory polypeptide (GIP), which makes it easier for your pancreas to release insulin and impacts how your body stores fat.
This dual-action approach offers all the benefits of semaglutide, but has shown even more effective for blood sugar control and weight loss.
Studies have revealed that both medications help lower blood sugar and can reduce (or eliminate) insulin dependence. However, recent research suggests that tirzepatide is slightly more effective in improving Hemoglobin A1c (HbA1c), a critical blood sugar indicator for patients with diabetes.
According to a study conducted by UC Irvine, both weight management medications also have the potential to dramatically decrease the risk for cardiovascular events (like heart attacks or strokes), with tirzepatide achieving a projected reducation rate of about 24% and semaglutide at about 20%. That being said, semaglutide may drive up your resting heart rate. More research is needed to get a complete picture of each drug’s impact on cardiovascular health.
Semaglutide and tirzepatide share many of the same potential side effects, including…
Nausea & vomiting
Constipation
Diarrhea
Abdominal discomfort
Hypoglycemia (low blood sugar)
And other gastrointestinal problems
Both semaglutide and tirzepatide are administered via subcutaneous injections. But the dosage protocols differ significantly.
Ready to discuss your options with a qualified healthcare provider in Wilmington or Leland, NC who focuses on weight loss and diabetes management?
Request a personal consultation with the team at BioSymmetry Wilmington—register as a new patient today!