ADACC Network

04/30/2025

Dr. Anne Murray, a member of the ADACC Network, collaborated with others to conduct a secondary data analysis using data from the ASPREE, ALSOP, and ASPREE-XT studies to explore whether social determinants of health could be a risk factor contributing to dementia.

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INTRODUCTION Social determinants of health (SDH) are recognized as contributing factors to cognitive disorders, but their collective influence on dementia risk remains unclear. METHODS A gender-di...

04/16/2025

In a first-of-its-kind national survey, Drs. Soeren Mattke and Ying Liu, members of the ADACC Network, and their colleagues examined the first 924 patients in the United States to receive amyloid-targeting treatment for Alzheimer’s disease outside of clinical trials, between 2021 and 2023. The study highlights key characteristics of this early patient group.

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04/09/2025

A member of the ADACC Network, Dr. Nicole Fowler, collaborated with colleagues to conduct a cross-sectional, nationally representative survey study—the National Survey of Healthcare Organizations and Systems (NSHOS II) for Physician Practice Survey—in 2022–2023. The survey identifies how prepared primary care clinics are to care for patients with ADRD. One of their findings was that “most practices have processes to screen for ADRD and refer patients for ADRD diagnostic testing, although one-third to one-quarter, respectively, do not.”

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INTRODUCTION It is unknown how prepared primary care practices are to deliver recommended dementia care. METHODS A nationally representative survey of US primary care practices focused on care del...

04/01/2025

Dr. Neelum Aggarwal, a member of the ADACC Network, worked alongside colleagues on population-based cohort study to answer, “Is socioeconomic status (SES) across the lifespan associated with cognitive decline and brain characteristics?” The study found that, “Higher SES, mainly in adulthood, was associated with better cognitive function, less cognitive decline, and better brain characteristics, including white matter hyperintensities and total brain volume.”

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This cohort study examines associations of socioeconomic status across the lifespan with cognitive decline and brain characteristics in Black and White individuals in Chicago, Illinois.

03/19/2025

Jalayne Arias, a member of the ADACC Network, collaborated on a qualitative study that used semi-structured interviews with legal professionals. The study explored their experiences and professional insights on the legal, policy, ethical, and logistical challenges of providing adequate care to justice-involved individuals living with dementia.

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Crime, Incarceration, and Dementia: An Aging Criminal System - Volume 49 Issue 2-3

03/14/2025

📣 The 2024 ADACC Network Conference Proceedings have been published in The Journals of Gerontology!

Read the full proceedings: https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glaf052/8064633
(The PDF is available.)

Presentations from the 2024 ADACC Conference include:
➡️ The Significance of MCCs in AD/ADRD presented by Heather E. Whitson, MD, MHS
➡️ Use of Biomarkers in Medical Care presented by Marcel E. Salive, MD, MPH
➡️ Considerations for Implementation of AD/ADRD BBMs presented by Michelle M. Mielke, PhD
➡️ Assessing Cognitive Impairment and Determining Etiology among Patients with Cancer presented by Heidi D. Klepin, MD, MS and Jeff Williamson, MD, MHS
➡️ Addressing Health Disparities in AD/ADRD Biomarkers presented by Antoine R. Trammell, MD, MPH and Ambar Kulshreshtha, MD, PhD
➡️ Clinician and Patient Perspectives on Plasma AD/ADRD Biomarker Testing presented by Kyra S. O’Brien, MD, MSHP and Nicole R. Fowler, PhD, MHSA
➡️ Ethical Implications of AD/ADRD Biomarkers Testing presented by Margaret Manchester, MPH

Watch recorded videos from the 2024 Annual Conference:
📽️ https://www.youtube.com/

Abstract. The Alzheimer’s Disease in Older Adults with Chronic Conditions (ADACC) Network is funded by the National Institute on Aging as a U24 cooperative

03/10/2025

The ADACC Network had an amazing time hosting the “Intersection of Multiple Chronic Conditions (MCCs) and Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD)" conference with the Advancing Geriatrics Infrastructure and Network Growth (AGING) Initiative! The days were filled with insightful presentations, enriching discussions, and interactive small-group sessions. We are grateful to have collaborated with American Geriatrics Society (AGS) in planning a wonderful conference!

02/21/2025

A member of the ADACC Network, Dr. F***y Elahi, worked alongside collaborators on a study that wanted to understand the relationship between neurovascular coupling and functional connectivity in individuals with MCI.

📘Read more about this study here:

INTRODUCTION Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI is critical for comprehending disease progression and e...

02/13/2025

Dr. Neelum Aggarwal, a member of the ADACC Networked, collaborated with colleagues on a study that used a service-learning program called Bringing Art to Life 🎨 to educate undergraduate students about dementia and other cognitive disorders. The study aims to “honor and validate people with dementia and other cognitive disorders through art therapy, other expressive arts, and life story/narrative.”

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IntroductionEmpathy is a fundamental element of high-quality healthcare, though it has been shown to be in decline among medical students and residents. Appe...

02/07/2025

A few members of the ADACC Network, Drs. Mielke, Karikari, and Hansson worked alongside their colleagues on a paper entitled “Diagnosis of Alzheimer’s Disease using plasma biomarkers adjusted to clinical Probability.” This manuscript includes a study of 6,896 individuals evaluated from 11 cohort studies from six countries and determined the positive and negative predictive value of five plasma biomarkers for amyloid-β pathology in cognitively impaired individuals in relation to clinical pretest probability.

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Therriault et al. provide a framework for the individual-level interpretation of plasma biomarkers by determining their positive and negative predictive values for amyloid positron emission tomography status in relation to patient age and clinical symptoms.

01/31/2025

Members of the ADACC Network, Drs. Michelle Mielke and Anne Murray, collaborated with their colleagues on a research review focused on AD plasma biomarkers. Their goal was to discuss the factors that could alter blood biomarker levels for detecting AD.

📘 Read their review here: https://lnkd.in/e3jcCyMN.

01/24/2025

🧠A couple of members of the ADACC Network, Drs. Jeffrey Dage and Oskar Hansson worked alongside other collaborators on a paper focused on therapies and biomarkers for Alzheimer’s disease. “This review focuses on the evidence of fluid biomarkers from recent amyloid-β-targeting clinical trials, summarizing biomarker data across 12 trials. It further proposes a simple framework to put biomarker guidance in the context of amyloid-pathway-targeted disease modification, delineates factors that impact biomarker data in clinical trials, and highlights knowledge gaps and future directions.”

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In this review, Hu et al. summarize fluid biomarker findings across 12 anti-amyloid-β clinical trials. The emerging biomarker data provide evidence of impact of the new therapies on the underlying pathophysiological processes of the AD, supporting the presence of a disease-modifying effect.