31/01/2024
Antiphospholipid syndrome (APS) may cause infertility by interfering with endometrial decidualization (changes in endometrium) and decreasing ovarian reserve. Studies also show an association between antiphospholipid antibodies and repeated implantation failure
In some people, APS causes the immune system to develop abnormal antibodies called “antiphospholipid antibodies”. These antibodies can affect blood flow and increase the risk of developing blood clots in the veins or arteries. In pregnant women, these antibodies can also affect the cells of the womb and the placenta, reducing blood flow to the baby.
Other complications of APS during pregnancy include:
* Recurrent miscarriage
* Early delivery
* Oligohydramnios
* Prematurity
* Intrauterine growth restriction
* Fetal distress
* Fetal or neonatal thrombosis
* Pre-eclampsia/eclampsia
* HELLP syndrome
* Arterial or venous thrombosis
* Placental insufficiency
Tests recommended for detecting APS include:
* Standardized enzyme-linked immunosorbent assay (ELISA) to detect aCL and aβ₂GPI
* Clotting assays for LA performed according to the guidelines of the International Society on Thrombosis and Haemostasis
* Beta-2 glycoprotein
* 1 antibody tests
Treatment for APS usually involves heparin or heparin with aspirin. Low-dose aspirin can be started before a person starts trying to get pregnant. Heparin must be given as an injection, either under the skin or into a vein.
If you have questions or think you may have APS, talk to your doctor or reproductive endocrinologist.
