CNS Inflammation (2025)

12/09/2024

Shedding light on brain inflammation in Alzheimer’s disease

University of Miami neuroscientist Oliver Bracko and his team are conducting cutting-edge research on Alzheimer’s disease that could lead to new treatments.

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Oliver Bracko, an assistant professor in the Department of Biology, and graduate students Nairuti Bhatt, center, and Zeynab Tabrizi posing for a photo in the laboratory where they conduct Alzheimer's research. Photo: Joshua Prezant/University of Miami

04/09/2024

Eastern equine encephalitis is spread by bites from infected mosquitoes. The disease can cause brain inflammation and may impair a person’s neurological and nerve functions.

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Eastern equine encephalitis, or EEE, is a rare but serious disease that can cause brain inflammation. There is so far no vaccine against it for humans.

27/08/2024

Investigators at Brigham and Women's Hospital, a founding member of the Mass General Brigham health care system, have demonstrated for the first time that astrocytes, non-immune cells, can acquire a memory of their previous interactions with the immune system, with important implications for our understanding of tissue inflammation.

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Immunological memory—the ability to respond to a previously encountered antigen or foreign substance with greater speed and intensity on re-exposure is a hallmark of adaptive immunity.

21/08/2024

Research from Washington University School of Medicine in St. Louis reveals how brain inflammation triggers extreme muscle weakness across several diseases, including viral infection, bacterial infection and Alzheimer’s disease.

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In fruit flies and mice, scientists ID possible way to block muscle fatigue in long COVID, other diseases

16/08/2024

Stroke, a major health issue worldwide, is increasing in prevalence, particularly among younger adults due to modifiable risk factors like obesity and hypertension.

Systemic inflammation, often marked by elevated inflammatory biomarkers like interleukin-1β (IL-1β), and IL-6, is a key factor in stroke development. Dietary patterns significantly affect this inflammation.

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The relationship between the dietary inflammatory index (DII) and stroke incidence.

07/08/2024

Strokes remain one of the most substantial side effects of transcatheter aortic valve replacement (TAVR), occurring in approximately 2% of patients following treatment. Cerebral protection devices (CPDs) such as the Sentinel Cerebral Protection System from Boston Scientific are designed to help alleviate this issue. They work by capturing and removing loose debris before it reaches the brain, but early studies have not identified a significant shift in stroke rates.

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Using a cerebral protection device during TAVR was associated with lower readmission rates, shorter hospital stays—and, yes, a lower risk of patients suffering a major stroke. A team of specialists with Cleveland Clinic shared their new findings in the Journal of the American Heart Association.

25/07/2024

A new study has identified new genetic and molecular risk factors that may reveal new pathways for treating patients after they experience their first stroke. The study identified CCL27 and TNFRSF14, two proteins that are associated with subsequent MACE, but not initial strokes. These proteins are known to activate inflammation, which plays a key role in the development of strokes and many chronic conditions and diseases.

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Study discovered genetic markers in inflammation that may be related to a second stroke or other major cardiovascular event following a stroke.

25/07/2024

People who survive an ischemic stroke are much more likely to develop major heart complications during the first month after their stroke, and, as a result, they also have an increased risk of death, heart attack or another stroke within five years, compared to people who don't develop heart problems soon after a stroke, according to research published in Stroke, the peer-reviewed, flagship journal of the American Stroke Association, a division of the American Heart Association.

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People who survive an ischemic stroke are much more likely to develop major heart complications during the first month after their stroke, and, as a result, they also have an increased risk of death, heart attack or another stroke within five years, compared to people who don't develop heart problem...

25/07/2024

More than half of stroke survivors do not receive rehabilitation after the first days of advanced stroke care. Instead of living for months or years with visible or hidden disabilities, stroke survivors can take advantage of new techniques of advanced rehabilitation to improve their function and freedom.

One condition, called spatial neglect – in which a person’s three-dimensional reality and spatial movements are distorted on one side – is particularly underdiagnosed and undertreated among those who have suffered strokes and other brain injuries.

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About half of those recovering from a stroke or a brain injury have spatial neglect. But prism adaptation therapy – noninvasive and easy to administer – can help.

24/07/2024

The rise in neurodegenerative diseases such as Alzheimer's and Parkinson's is becoming a significant challenge. However, the field of photobiomodulation (PBM), which is emerging as a promising alternative to conventional treatments, shows promise. A recent study published in Advanced Photonics Nexus introduces a noninvasive photonic approach that could revolutionize how we combat these debilitating diseases.

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As the world grapples with an aging population, the rise in neurodegenerative diseases such as Alzheimer's and Parkinson's is becoming a significant challenge. These conditions place a heavy burden not only on those afflicted but also on their families and society at large. Traditional treatments, i...

12/07/2024

Stroke stands as a predominant cause of mortality and morbidity worldwide, and there is a pressing need for effective therapies to improve outcomes and enhance the quality of life for stroke survivors. In this line, effective efferocytosis, the clearance of apoptotic cells, plays a crucial role in neuroprotection and immunoregulation.

To learn more, read the full article:

Stroke stands as a predominant cause of mortality and morbidity worldwide, and there is a pressing need for effective therapies to improve outcomes and enhance the quality of life for stroke survivors. In this line, effective efferocytosis, the clearance of apoptotic cells, plays a crucial role in n...

03/07/2024

Up to a third of people who experience a traumatic brain injury (TBI) have persisting symptoms, including headaches, sensitivity to stimuli, and difficulty thinking clearly. Even though as many as 20% of Canadians will experience a TBI in their lifetime, the causes of these persisting symptoms are poorly understood.

Previous research has linked astrogliosis, a type of inflammation that takes place in the brain, to TBIs. Dr. Jeffrey Meyer and his team set out to establish if astrogliosis might continue long after the initial injury and potentially have a role in the persisting symptoms afflicting some patients.

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Up to a third of people who experience a traumatic brain injury (TBI) have persisting symptoms, including headaches, sensitivity to stimuli, and difficulty thinking clearly. Even though as many as 20% of Canadians will experience a TBI in their lifetime, the causes of these persisting symptoms are p...

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