18/02/2022
Eat Fish to Fix Your Aging Brain
Dietary supplementation with a fish mix containing omega-3 fatty acids and low molecular weight peptides prevented the age-related memory deficits.
In addition, the fish mix displayed anxiolytic activities with the reduction of anxiety in aged mice, restored the corticosterone levels similar to normal following stress and decreased the hypothalamic stress response.
These effects on behaviour can be explained by the immunomodulatory and neuroprotective properties of the fish that limited pro-inflammatory cytokines and increased the expression of growth factors such as BDNF and NGF in vitro.
Thus, n-3 LC-PUFAs and low molecular weight peptides contained in the fish can play an important role in the limitation of neuroinflammation and stress response alterations during aging and
Are a strategy for the prevention of age-related cognitive decline.
Brain aging is characterized by a decline in cognitive functions, which can lead to the development of neurodegenerative pathologies. Age-related spatial learning and memory deficits are associated with a chronic low-grade inflammation. Anxiety disorders and stress response alterations, occurring fo...