25/06/2025
The Glycosaminoglycan (GAG) layer Explained 👇
The GAG layer is the lining of the bladder. It protects the inside of the bladder from bacteria and the irritants found in urine. In certain bladder conditions, like Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) and recurrent urinary tract infections (rUTIs), the GAG layer becomes damaged which means the bladder lining is unprotected. This can cause irritation and damage; resulting in pain.
Nerve endings which are usually protected by the GAG layer may also become exposed; changing the signals sent to the brain about when to urinate; even a very small amount of urine in the bladder can feel like you’re about to burst. The risk of infection is also higher.
So, what can help?
As a healthy GAG layer is made of more than one component, it follows that an effective therapy will contain a combination. iAluRil is a medical device presented in a prefilled syringe. The solution within the syringe is instilled directly into the bladder to help rebuild the damaged bladder lining.
Because two of the three main ingredients in iAluRil, hyaluronic acid (HA) and chondroitin sulphate (CS), are also components in the GAG layer, it can effectively replenish the damaged GAG layer. In doing so, the symptoms associated with bladder conditions; pain, urgency and frequency, may be alleviated and the risk of bacterial infection is significantly reduced.