04/03/2022
Counteracting Alzheimer's and Dementia in General:
BDNF - brain-derived neurotrophic factor improves learning and memory retention. It is a kind of "aftercare" for older brains. It helps neurons heal and form new connections.
When BDNF levels get low, which usually happens with age, the grey matter in our brains shrinks and we have fewer neural connections. This makes it harder to form and retain memories.
Low levels of BDNF are associated with anxiety. Binge drinkers have low BDNF levels. BDNF levels are extremely low in Alzheimer's and dementia patients.
About 30% of people of European descent have a mutation known as rs6265 or the Val66Met polymorphism which results in lower BDNF levels. If you inherit this from both your parents, your likelihood of having dementia as you age increases about 12-fold.
What decreases our levels of BDNF? Eating processed foods and sugars, stress, lack of adequate sleep, inflammation, obesity, insulin resistance, type 2 diabetes, social isolation, loneliness, depression, substance abuse, breathing polluted air, and lack of sunlight on your skin.
So how do we increase our levels of BDNF?
Yoga, meditation, and other stress-reducing activities.
Intense aerobic exercise, resistance training (weight lifting), body-building anaerobic exercise. Exercise raises BDNF fast, but the greatest effect comes after some weeks of regular exercise.
Solid social connections with family and friends.
Breathing fresh air and getting sunlight on as much of your skin as possible.
Polyphenols and antioxidants. Dark chocolate is rich in polyphenols. The more bitter olive oils are rich in polyphenols. Olive leaf extract is sky-high in polyphenols. Coffee is rich in polyphenols. Best of all is an extract of fresh coffee berries.
Butyrate, a short-chain fatty acid found in butter also appears to raise BDNF
Omega 3 fatty acids from eating oily fish increase BDNF - and are associated with reduced depression.
A high protein diet, especially when combined with exercise.
A low-carb diet. When you are on a low-carb diet, your liver produces a ketone called Beta-hydroxybutyrate which increases BDNF levels. The combination of fewer than 50 grams of carbs per day plus high-intensity interval training (HIIT) is very effective.
If you don't want to go on a keto diet, temporary carb restriction can be very effective. Intermittent fasting has little effect on BDNF levels. But after 48 hours of fasting, BDNF levels can increase by nearly 4x!
MCT oil contains Beta-hydroxybutyrate. Eating it will give you a similar effect as carb restriction.
Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant and possesses neuroprotective effects. It increases levels of BDNF. Green tea also contains l-theanine which greatly reduces anxiety and the jitters that caffeine can produce.
Attend to the lifestyle changes listed above before adding nutrients that boost BDNF.
My morning drink for increasing BDNF levels:
Coffee with some butter, MCT oil, coconut oil, cream, organic cocoa powder, vanilla extract.
I often also take a capsule of green tea extract. It is extremely bitter so I don't mix it into my coffee drink.