Redox Stasis

13/02/2023

15/01/2023

Methylation status/development starts in the womb and is influenced by the generation way before your own birth. For example, copper metabolism is tied to DNA methylation in the placenta and the copper-associated patterns in DNA methylation mediate normal fetal development. As you can see mineral imbalances strongly influence fetal development. Epigenetics leaves a wake throughout history that also paints a picture of what human health will be like centuries later. Will there be a point in time that people have so many health issues that their quality of life is dramatically reduced in the presence of an ever-increasing toxic enviroment with poor dietary habits? Our predecessors help build the world of tomorrow but what happens when our predecessors (society) lose their way decade after decade? We build a toxic world that produces an unhealthy and destructive population.

15/01/2023

‼️During a zinc deficiency, the methyl group of the S-adenosylmethionine in the liver turns over much more slowly‼️

✅ This was reflected in the depressed rates of methylation of various macromolecules, particularly DNA and histones.

✅ The synthesis of nuclear proteins, histones and nonhistone chromosomal proteins, were depressed in the livers from zinc-deficient rats.

✅ The enzyme methionine adenosyltransferase converts methionine, in the presence of ATP, to S-adenosyl-L-methionine, the main biological methyl donor.

⁉️How is copper toxicity linked to impaired methylation⁉️

✖ The accumulation of copper can lead to the reduction of S-adenosylmethionine synthesis in the liver.

✖ The activities of several enzymes of the methionine cycle were affected, during copper accumulation.

✅ The main change was a redox-mediated 80% decrease in the mRNA levels of the methionine adenosyltransferase regulatory subunit as compared to the control group‼️

⚠️ Remember, the enzyme methionine adenosyltransferase converts methionine, in the presence of ATP, to S-adenosyl-L-methionine.

✅ During copper toxicity, the production of S-adenosyl-L-methionine is significantly reduced ➡️ leading to methylation dysregulation.

⁉️Do you have copper toxicity⁉️

14/01/2023

‼️Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a Parkinson's disease model‼️

✅ Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease‼️

✅ NF-κB, a key activator of inflammation primes the NLRP3-inflammasome for activation by inducing pro-IL-1β and NLRP3 expression.

✅ In PD patients, the proportion of dopaminergic neurons with immunoreactive NF-κB in their nuclei was more than 70-fold than in control subjects.

✅ Zinc deficiency-induced NF-kB activation promotes hypertension by driving renal sodium reabsorption.

↪ Also known as a high Na/K ratio‼️

✅ Potassium conductance influences dopamine release from midbrain dopaminergic neurons.

↪ Parkinson's disease is closely associated with the dysfunction of potassium channels.

‼️Low potassium promotes NF-κB/DNA binding in neuronal apoptosis induced by potassium Loss‼️

⚠️ Nickel, Lead and Mercury induce inflammatory activation via NF-κB.

⚠️ Lead exposure induces dopaminergic neurotoxicity and is known to prohibit the stimulated release of dopamine.

⚠️ Also, excess manganese potentiates the effects of inflammatory cytokines on NF-κB-dependent expression of nitric oxide synthase 2 in astrocytes‼️

⚠️ Iron directly elicits the signaling required for activation of NF-kB‼️

✅ As a result, NF-κB is a well-established inflammatory transcription factor that fuels neurodegeneration.

⁉️Do you have a high Na/K ratio⁉️

14/01/2023

I tried seeking out why semen retention is so beneficial for overall brain and body function. First we must go into what makes-up s***m. Semen contains citric acid, free amino acids, fructose, enzymes, phosphorylcholine, prostaglandin, potassium, and zinc. Putrescine, s***midine and s***mine are also involved in s***m production and are widely distributed in the human body. Earlier studies quantified s***mine levels and found that there is a lot of it in human s***m. Much more than in other other tissues of the human body! How is s***mine made in the body? Putrescine combines with decarboxylated S-adenosylmethionine and then transformed into s***midine and s***mine. Why is this important? SAMe helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. S-adenosylmethionine is a substrate for de novo synthesis of choline. Your brain and nervous system need choline to regulate memory, mood, muscle control, and other functions. The question is... can semen retention cause the body to retain more of these vital nutrients and compounds for improved brain and body function?

13/01/2023

Is Vitamin D blood testing an accurate measurement of Vitamin D utilization? Yes and no. It can have the same drawbacks as serum hormone testing. An individual can have normal or elevated hormone levels in their blood and still have symptoms of a deficiency. Blood analysis does not always measure cellular health. In the case of Vitamin D, high levels in the blood can represent impaired utilization of the hormone and/or chronic inflammation. Even normal levels dont always illustrate sufficient vitamin D utilization. For example, the VDR gene provides instructions for making a protein called vitamin D receptor, which allows the body to respond to vitamin D. What if VDR expression is reduced? The body will not be able to optimally utilize vitamin D. In one study, the VDR gene expression of a zinc deficient group was downregulated 88.89%!!! During a zinc deficiency, not only is vitamin d not utilized properly but inflammation, also, usually increases. Having enough magnesium, which plays an important role in activating Vitamin D, does not always guarantee the hormones proper utilization on the cellular level.

11/01/2023

Practitioners often times believe one needs to supplement extra iron in order to improve iron status. The train of thought is that one needs more iron in order to correct an iron deficiency or anemia but this is not necessarily true. It is how the body uses iron that is important. Practitioners should focus more on improving the body's ability to use/transport iron. Iron isn't a one-man team... so why treat it that way? A whole-systems approach is better but more complex. It is also more complex than just consuming more iron-rich foods- that won't necessarily fix the problem either. At times, when practitioners see that serum iron status/utilization is improved... it isnt because you had one consume more iron rich foods... its because of the other minerals in that food or supplement that improved iron bioavailability. For example, impaired iron absorption can be caused by a decrease in zinc, which is found in the structure of enzymes that coordinate or catalyst iron metabolism. Also when you detox heavy metals, iron utilization improves significantly. To correct one mineral imbalance can require increasing or decreasing that of another.

10/01/2023

There is a problem behind thyroid medication... it doesnt use minerals to speed up and/or improve thyroid function. Whenever you use exogenous hormones to improve hormone status you can actually worsen the delicate balance of minerals. The mineral ratios can get worse. It can also make a person feel worse later on. There may be an initial period of more energy but the negative impact comes later. In this sense it provides an illusion of energy until it messes up the mineral levels and ratios so much to the point that one's health goes downhill. I see this happen as the TSH level significantly lowers but the T4 and T3 level only slightly increases. During this time, a hair test can still show low zinc and copper levels while the calcium/potassium ratio decreases. Essentially, you "speed up" the thyroid but the adrenals are still sluggish. By this, thyroid meds can negatively impact the Na/K ratio. Eventually the hormone medication lowers the Na/K ratio. This is one reason why Dr. Paul Eck said thyroid medication is an illusion of energy and vitality.

09/01/2023

I always say... the day I become a coffee drinker will be the day that I become a slow oxidizer. Caffeine increases dopamine levels in the same way that he**in and co***ne do... caffeine is just weaker. Caffeine blocks adenosine reception so you feel alert and it injects adrenaline into the system. This can cause a cycle of up's and down's. This is what people with low energy suffer from. I dont find many fast oxidizers who drink coffee. Fast oxidizers usually already have plenty of dopamine and adrenaline. Elevated dopamine during copper deficiency (fast oxidation) can be due to limiting dopamine-β-monooxygenase. On the opposite end, when copper is elevated-dopamine levels can decrease. Low dopamine is linked to certain symptoms of depression, such as low motivation. A slow oxidizer is always looking for a pick-me-up. Slow oxidizers also have elevated tissue magnesium which may be able to block dopamine and glutamate release.
Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens- a key structure involved in emotional and motivation processing and increasing reward and pleasure.

05/01/2023

At the time of America's founding in 1776, the average newly-minted American citizen could expect to live to the ripe old age of 35. I dont know how true this is and if true then this may be due to starvation, hard labor, war, social classes and etc (similar to today)... meanwhile, most of the founding fathers lived to a ripe old age of 80 or beyond without the medical advances that we have today or even the sheltered lifestyle and living accommodations that we now have. So are people really living longer lives due modern medical advances? Or are people living longer than they normally would given our poor diet, pollution, heavy metals, EMFs, crime... you name it? So if you were to take away the poor diet, pollution, heavy metals, EMFs , lab made viruses and etc then people would still live to 80 or even way longer without the medical advancements today save the lavish living accommodations and beneficial technology. In a way we can say medical advancements are allowing people to live longer lives (or in this case a normal lifespan) but in the midst of growing ignorance and toxicity but with a lower quality of life.

02/01/2023

I would have to say that heavy metal exposure usually does not show severe consequences until later in life. For example, 90-95% of the total lead burden is contained within bone. A person can be exposed to lead early in life but not experience the full amount of side effects until decades later. So from about age 25 to age 50, bone density tends to stay stable with equal amounts of bone formation and bone breakdown. After age 50, bone resorption outpaces bone formation and bone loss often accelerates. Unfortunately, bone resorption influences the release of bone lead stores into circulation. Natural aging of the skeletal system can cause more heavy metals to be released into the blood stream. Why is this important?! In one Alzheimer's disease study, the average blood lead level was 22.22 ± 28.57 μg/dL!! ➡️Which was significantly higher than controls. There is no safe blood level but less than 5 micrograms per deciliter (µg/dL) is considered safe enough! Blood lead levels can increase by 4 to 5 times higher than what is considered 'safe enough' during the aging process even when lead exposure has stopped.

27/12/2022

Why would the telecommunication industry come out and say well there are some dangers to EMF exposure coming from cellphones, WiFi and etc? It would not benefit them in anyway. The objective is never to plant that seed into the minds of the people because they may start investigating more into the matter and/or start fearing the possible dangers. That is one fear they dont want people to be concerned about because it would negatively impact their end-goal and profit. Also, knowledge is power and it is important to control what people know or concern themselves about. It is not about sharing truth... it is about creating a digital or virtual world regardless of the consequences. We should be very concerned about how far they will take it. It is almost like a disease.

26/12/2022

In time people wont even have a brain left if we keep going down this road. Civilizations always find a reason to collapse... history of man tells it all... does it not?

20/12/2022

Circulation determines how well you recover and heal. You can take every supplement known to man but if you have poor circulation it wont be nearly as effective as in someone with superb circulation. It is common sense but sometimes not stressed enough. For example, why is exercise so beneficial? It comes down to improving circulation by increasing your heart rate. It also whips the adrenals. I can review blood work of people with good levels of white blood cells but they are in slow oxidation... which automatically reduces circulation. Therefore, their immune response is automatically impaired. Adrenal insufficiency impairs circulation! Researchers found that adrenal extracts can act as remarkable cardiovascular stimulants! This is why in hair analysis research, we stress the need and science of balancing the oxidation rate for optimal healing! The body eventually is able to heal itself. Anything that improves circulation will speed up the process of healing.

20/12/2022

Understanding ferritin is a bit challenging because practitioners can make the assumption that ferritin is only influenced by iron or copper when this can be just part of the issue. Ferritin, an iron homeostasis protein, has important functions in transition and storage of many heavy metal ions. Therefore, ferritin is also used by the body for heavy metal detoxification. Ferritin has a strong affinity for certain metal ions besides iron. Fixing a zinc deficiency can help detox excess iron and heavy metals from the tissues/organs, which can raise the ferritin level at times. Zinc detoxifies iron and heavy metals. A zinc deficiency can cause heavy metals and iron to accumulate. A Copper dysregulation can also impact ferritin levels as seen on blood tests. Treating each scenario has to be done in a specific way according to the Na/K ratio and oxidation rate. Raising or lowering the Na/K ratio can influence the ferritin and iron levels.

19/12/2022

⁉️ Can Parkinson's Disease be stopped⁉️ Depends on the Stage.

‼️What allopathic medicine does not tell these patients⤵️

▶️ Meta-analysis indicate that patients with hypothyroidism and hyperthyroidism were at a 1.5 times greater risk of developing Parkinson disease.

✅ High Calcium and Magnesium and with low Sodium and Potassium represents slow oxidation.

‼️There is also heavy metal accumulation‼️

💇‍♂️💇‍♀️ Hair analysis research indicates that the causes of PD are chronic manganese or lead toxicity. Other nutrient deficiencies and constipation can also play a role.

✖ Mongolian subjects with PD showed high accumulated levels of manganese, iron, lead, cadmium and aluminum accumulations in hair, as compared with Japanese subjects.

⚠️ These levels were correlated with urinary 8-OHdG levels. The subjects with Parkinsonism and arthritis demonstrated higher levels in these heavy metals than healthy subjects.

✅ The mean urinary 8-OHdG increased with each stage of Parkinson's Disease and was not influenced by the current dose of DOPA.

✖ Vanadium, manganese, nickel, and lead exposures were positively associated with 8-OHdG levels‼️

🔺️ At times the Na/K ratio rises significantly, indicating acute inflammation and the need for more zinc. Reduced zinc levels in the serum and plasma are associated with an increased risk for PD.