Dr Nikki Adler

05/06/2025

17/02/2025

Dermatology Research
Our research plan focuses on translational projects that will enable better understanding of the immune mechanisms of skin cancer and inflammatory skin diseases, better ways to prevent and to treat these disorders, and better understanding of the impact of skin disease on quality of life. A key area of focus is on groups at extreme risk of skin cancer.

In 2023 the results of the RPA-led multicentre Phase 3 trial of nicotinamide (vitamin B3) for skin cancer chemoprevention in transplant recipients were published in the New England Journal of Medicine. Work using the novel technology of imaging mass cytometry is ongoing in keratinocyte cancers and melanomas arising in immune suppressed and immune competent individuals. Collaborations with The Charles Perkins Centre (CPC) and the RPAH Department of Tissue Pathology and Diagnostic Oncology have enabled this work to be undertaken with MPhil student Dr Catherine Zilberg supervised by Professor Damian, Associate Professor Ruta Guta (Tissue Pathology and Diagnostic Oncology) and Dr Angela Ferguson (CPC).

Ongoing work in human oral squamous cell carcinoma is examining the role and nature of epithelial plasticity in cancer development and progression. We have established monoclonal cell lines from individual tumours and demonstrated that they interact with respect to cell growth and drug resistance. This suggests that a novel mechanism involving symbiosis between clones might promote tumour malignancy and resistance to therapy.

Studies with the Sydney Melanoma Diagnostic Centre are assessing the utility of new ex-vivo confocal microscopy for ensuring clear surgical margins and enabling rapid diagnosis of skin cancers, and a Medical Research Futures Fund supported clinical trial of topical sirolimus to reduce skin cancer incidence in transplant patients will commence soon.

Investigator initiated trials include intralesional triamcinolone for lower leg squamous cell carcinomas in elderly patients, and perioperative propranolol and celecoxib to modify the tumour microenvironment and reduce recurrence in patients with nodal and cutaneous metastatic melanoma.

Our Department's psoriasis research program continues with an evaluation of Drug survival of biologic treatments in patients with psoriasis. Investigators in this collaborative RPAH/Westmead project include Associate Professor Patricia Lowe, MPhil candidate Samantha Ting, Professor Pablo Fernandez P***s and Dr Annika Smith. The PSoHO study of adults with moderate to severe plaque psoriasis has completed recruitment. The PSoHO study, an international observational study of health outcomes in the biological treatment of moderate to severe plaque psoriasis has now completed recruitment. The main purpose of the study is to compare how effective different biologic therapies are at treating plaque psoriasis over time, and to gain a better understanding of how plaque psoriasis affects overall health and quality of life.

Our Research Team
Professor Diona Damian
Diona Damian is Professor of Dermatology at The University of Sydney, Clinical Academic in Dermatology at Royal Prince Alfred Hospital and Associate of the Melanoma Institute Australia. Her research over the past 27 years has focussed on the role of the skin's immune system in the causation, prevention and treatment of skin cancer. This work has been funded primarily by a range of Cancer Institute NSW, Cancer Council NSW and NHMRC Project Grants and Fellowships. Professor Damian's findings in the fields of skin cancer chemoprevention with nicotinamide (vitamin B3), the effects of UV radiation on the skin's immune responses and the use of topical immunotherapy with diphencyprone for metastatic melanoma have been translated into clinical practice in Australia and internationally.

Current research is examining skin cancer prevention in organ transplant recipients, and the immune microenvironment within skin cancers in transplant recipients and in people with normal immunity. Professor Damian and Drs Moreno, Lin and Ge are also working with the Sydney Melanoma Diagnostic Centre to assess the use of a new ex-vivo confocal microscope (first in Australia) that will let them examine the microscopic edges of skin cancers in clinic to check whether there are clear margins (microscopically controlled excision).

Clinical Associate Professor Guy Lyons
Clinical Associate Professor Guy Lyons' research group uses a combination of mathematical modelling and novel laboratory-based models to follow the fate of cells during carcinogenesis in the skin, eye and mouth. They have found that the location of stem cells for the cornea at its perimeter, together with the limited lifespan of the cells that they give rise to, causes a flux of cells towards the centre of the cornea, and that UV radiation increases this. Professor Lyons' group has also used models of oral carcinogenesis, together with advanced image analysis techniques, to examine the evolution of clones of cells during the development of squamous cell carcinomas of the tongue. The group have shown that tongue cells exposed to a chemical carcinogen used as a surrogate for to***co evolve much faster than those from untreated tongues. Cell lines have been established from the tumours that arise so that the gene mutations that underlie malignant behaviour can be understood, and new strategies for treating oral cancer can be devised and tested.

The group has also been elucidating the mechanisms by which squamous cell carcinomas develop in the skin and other tissues. Collaboration with investigators at the University of NSW and the Save Sight Institute, have found that UV radiation has dramatic effects on the mechanisms by which cell proliferation is maintained in the cornea. In collaboration with investigators at the Garvan Institute and University of California, San Diego, they have developed novel fluorescent cell lines for study of squamous cell carcinoma, determined the mutations that they have and identified a key pathway that drives malignancy in them.

Clinical Associate Professor Patricia Lowe
Clinical Associate Professor Patricia Lowe is a Senior Staff Specialist. Recent research has included the Clinical Trial AMAGINE-3 - A Phase 3 Study to Evaluate the Efficacy and Safety of Induction and Maintenance Regimens of Brodalumab Compared With Placebo and Ustekinumab in Subjects With Moderate to Severe Plaque Psoriasis. This international multi-centre clinical trial looked at the effect and safety of a novel biologic agent, Brodalumab, in the treatment of psoriasis, a common skin disease. This agent is an inhibitor of an interleukin-17 receptor (IL-17R) and is given as a subcutaneous injection. Additionally, the trial compared the efficacy of this agent to a currently PBS listed biologic agent of another class, Ustekinumab (an IL-12/23 inhibitor).

19/06/2024

♻️ Instructions for use:
1.Clean and dry the affected area thoroughly.
2.Apply the medicated plaster to the affected area.
3.It is preferable to use it at night when the body is naturally detoxifying, enhancing its effectiveness.
4.Use once nightly for optimal results.

Uses:
Osteoarthritis 🌿, Back Pain, Joint Pain, Arthritis, Sports Injuries, and Accidents.
Detoxification 💧, Boosts Metabolism; Fat Reduction, Body Shaping; Edema Elimination.
Improves Mobility, Reduces Swelling, Pain Relief. Soothes Irritated Skin and Sore Muscles.
Treats Bruises, Sprains, and Fractures. Repairs Tendons, Ligaments, and Connective Tissues.
Do not use on open wounds.

Product Description:
Ingredients: Curcumin, Black Pepper Extract, Glucosamine, Cayenne pepper ,Milk Thistle, Peppermint Menthol, Beeswax, Rosin, Vitamins, Essential Oils - 🌸 Lavender, Tea Tree, Lemon.
Description: This herbal ointment medicated plaster uses a unique natural formula, produced in the rolling hills of Wisconsin, with many herbs sourced from the family’s organic gardens. Each patch is infused with local pure wild herbs and essential oils, local beeswax, and a lot of love! ❤️
Main Components and Benefits:
Curcumin: Improves blood circulation, boosts metabolism, has anti-inflammatory, analgesic, anti-proliferative, and detoxifying effects. Curcumin accumulates in the synovium, inhibits crystal formation, stimulates lymphocyte activity, and treats joint inflammation. It also aids cartilage repair, slows osteoarthritis progression, and improves joint function. Thus, it can be used to treat arthritis, joint hyperplasia, and obesity.
Black Pepper Extract: Contains multiple active ingredients that can increase body heat production, promote fat breakdown and burning. It enhances cellular insulin sensitivity, promotes glucose utilization and metabolism, helping control blood sugar levels, prevent insulin resistance, and reduce liver fat deposition. When used with glucosamine, it can improve glucosamine utilization, thus treating arthritis and reducing obesity symptoms.
Glucosamine: An amino monosaccharide that connects tissues, synovial fluid, and other structures. It is a precursor of joint cartilage matrix. Topical glucosamine can act on joint cartilage, promoting its integrity. Topical glucosamine can be absorbed through the skin, quickly reaching the joint area to enhance its efficacy.
Cayenne Pepper 🌶️: Known for its active compound capsaicin.
Pain Relief: Capsaicin helps alleviate joint pain by depleting the neurotransmitter substance P, which transmits pain signals to the brain. Reducing substance P lowers pain sensation.
Anti-Inflammatory: Helps reduce joint inflammation.
Improves Circulation: Enhances blood flow, delivering more oxygen and nutrients to joints, aiding in their repair and maintenance.
Why Choose Organic Herbal medicated plaster?
Natural remedies are either loved or scoffed at. Most people implicitly trust traditional medicines. However, studies show that various antibiotics (considered the greatest drug forms in history) are linked to a 41% increase in Parkinson’s disease incidence, a 40% increased risk of stomach cancer, a 40% increased risk of lung cancer, a 60% increased risk of rheumatoid arthritis, and a 23-56% increased risk of depression. They are also associated with an increased risk of our number one killer, heart disease.

The skin is the largest organ in the body, making it an excellent substrate for quick absorption and rapid effects. Once absorbed through the skin, our organic herbal medicated plaster take immediate effect. Unlike essential oils that must be metabolized in the body, patches can be precisely applied to any part of the body.

17/06/2024

Barbara O'Neill is a well-known educator and well sought-after lecturer for natural health and healing. She is a wonderful caring and healthful Australia lady who has helped hundreds of thousands people around the world. Barbara helps people to embrace a healthier, happier and longer life though simple lifestyle changes.

This video is part of her full lecture at Royal Oak Church in Feb 2016. For the full video, please visit this link here:https://www.youtube.com/watch?v=YgjzY6cyXEM

07/05/2024

🔥Discover the Power of Nature with Revolutionary Treatment! SALICYLIC ACID, TEA TREE OIL, AND BEE VENOM THERAPY, THESE THREE INGREDIENTS EFFECTIVELY TREAT WARTS, HPV, MELANOMAS, ACNE, AND ECZEMA. Experience the natural solution for healthier skin!
Dr. Eric Berg has recommended salicylic acid, tea tree oil, and bee venom therapy for their various health benefits. Here’s a brief overview of each:
✅Bee Venom Therapy:
Benefits: Bee venom contains compounds that have anti-inflammatory and analgesic properties. It is believed to stimulate the immune system, reduce pain and swelling, and improve skin health.
Uses: Utilized in skincare products to help with anti-aging, acne, and skin rejuvenation. It's also used in some therapeutic treatments for conditions like arthritis and multiple sclerosis.
These natural remedies are often highlighted by Dr. Berg for their potential to support overall health and address specific skin concerns.
Accelerate the process of recovery, making removal easier than ever! 👋
Natural Ingredients: All ingredients are derived from natural plants and ethically sourced bee venom, ensuring a safe and cruelty-free product.

07/05/2024

🔥Discover the Power of Nature with Revolutionary Treatment! SALICYLIC ACID, TEA TREE OIL, AND BEE VENOM THERAPY, THESE THREE INGREDIENTS EFFECTIVELY TREAT WARTS, HPV, MELANOMAS, ACNE, AND ECZEMA. Experience the natural solution for healthier skin!
Dr. Eric Berg has recommended salicylic acid, tea tree oil, and bee venom therapy for their various health benefits. Here’s a brief overview of each:

✅Tea Tree Oil (Melaleuca Alternifolia):
Benefits: Tea tree oil is praised for its antiseptic and anti-inflammatory properties. It can help with acne, fungal infections, and other skin issues.
Uses: Applied topically in diluted form to treat acne, cuts, insect bites, and fungal infections. It’s also used in various skincare and hair care products.
Uses: Utilized in skincare products to help with anti-aging, acne, and skin rejuvenation. It's also used in some therapeutic treatments for conditions like arthritis and multiple sclerosis.
These natural remedies are often highlighted by Dr. Berg for their potential to support overall health and address specific skin concerns.
Accelerate the process of recovery, making removal easier than ever! 👋

05/05/2024

🔥Discover the Power of Nature with Revolutionary Treatment! SALICYLIC ACID, TEA TREE OIL, AND BEE VENOM THERAPY, THESE THREE INGREDIENTS EFFECTIVELY TREAT WARTS, HPV, MELANOMAS, ACNE, AND ECZEMA. Experience the natural solution for healthier skin!
Dr. Eric Berg has recommended salicylic acid, tea tree oil, and bee venom therapy for their various health benefits. Here’s a brief overview of each:
✅Salicylic Acid:
Benefits: Salicylic acid is well-known for its effectiveness in treating acne and other skin conditions. It helps to exfoliate the skin, unclog pores, and reduce inflammation.
Uses: Often found in skincare products like acne treatments, exfoliating pads, and wart removal solutions.
Uses: Utilized in skincare products to help with anti-aging, acne, and skin rejuvenation. It's also used in some therapeutic treatments for conditions like arthritis and multiple sclerosis.
These natural remedies are often highlighted by Dr. Berg for their potential to support overall health and address specific skin concerns.
Accelerate the process of recovery, making removal easier than ever! 👋

05/05/2024

17/08/2023

You are never too old to acquire new knowledge and a new skill🥳🥳🥳

13/08/2023

Avoid refined foods, fat and sugary foods, consume more fibre, protein and stay hydrated in order to maintain a healthy body weight..... Follow, like and share to receive more tips.