Creative Bioarray

29/08/2025

An age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8+ T cells, suggesting that modulating adipocyte-derived leptin levels may be a promising therapeutic strategy for older cancer patients. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00383-0

29/08/2025

Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors
https://www.nature.com/articles/s41586-025-09433-w

20/08/2025

Initiation of meiosis from human iPSCs under defined conditions offers the potential to treat most cases of infertility and expand reproductive autonomy. https://www.science.org/doi/10.1126/sciadv.adu0384

20/08/2025

Allogeneic microglia replacement to treat fatal brain diseases https://nature.com/articles/s41586-025-09461-6
https://nature.com/articles/s41586-025-09477-y

As tissue resident macrophages of the central nervous system (CNS) parenchyma, microglia perform diverse essential functions during homeostasis and perturbations1. They primarily interact with neurons via synaptic engulfment and through the rapid elimination of apoptotic cells and nonfunctional syna...

12/08/2025

Sca1- committed progenitor cells were highly efficient to replace microglia following intracerebral injection, which may pave the way for the development of allogeneic microglial cell therapies for the brain. https://www.nature.com/articles/s41586-025-09461-6

12/08/2025

Respiratory viral infections awaken metastatic breast cancer cells in lungs https://www.nature.com/articles/s41586-025-09332-0

28/07/2025

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures https://www.cell.com/cell/abstract/S0092-8674(25)00749-4

28/07/2025

Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories https://www.cell.com/cell/fulltext/S0092-8674(25)00750-0

23/07/2025

Relative importance of the anti-apoptotic versus apoptosis-unrelated functions of MCL-1 in vivo https://www.science.org/doi/10.1126/science.adw1836

23/07/2025

Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy https://www.cell.com/cell/abstract/S0092-8674(25)00570-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425005707%3Fshowall%3Dtrue

10/07/2025

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids https://www.cell.com/cell/abstract/S0092-8674(25)00628-2

10/07/2025

Advancements and challenges in CAR T cell therapy in autoimmune diseases https://www.nature.com/articles/s41584-024-01139-z