10/05/2026
💬 Perspective by Daniel Lieberman, PhD; Daniel Aslan, PhD, and Steven Heymsfield, MD: Although -1 receptor agonists have transformed pharmacologic approaches to , most patients discontinue use within one year and are at risk for rapid weight regain.
Exercise at appropriate doses achieves high efficacy for weight control and preservation of fat-free mass, yet rarely succeeds in real-world clinical practice due to low adherence.
Physicians are encouraged to routinely assess physical activity levels, communicate the health benefits of exercise, and collaborate with patients to mitigate barriers by creating personalized, feasible activity plans, potentially involving allied health professionals.
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