The GUT CLUB

31/01/2026

New from Mattel
https://youtu.be/dEuPT2hX0lg?si=1OB_375HC_CdFjL7
What about profound autism doll, too? Maybe Ken?

In partnership with the Autistic Self Advocacy Network, the new autistic Barbie doll was designed with thoughtful care and deep insight - recognizing that th...

31/01/2026

BACTEROIDES HIGHER IN AFRICAN AMERICAN WOMEN

'Associations Between Race, Perceived Psychological Stress, and the Gut Microbiota in a Sample of Generally Healthy Black and White Women: A Pilot Study on the Role of Race and Perceived Psychological Stress' (2018)
https://pmc.ncbi.nlm.nih.gov/articles/PMC6113071/pdf/nihms972636.pdf

"When looking at specific taxa, we identified a higher abundance of Bacteroides among black women in our study which is consistent with our hypothesis that blacks would have a greater abundance of colorectal cancer-associated bacteria. When comparing Bacteroides between native Africans, a group with a very low incidence of colorectal cancer, and African Americans, the abundance of Bacteroides was much higher among African Americans. To our knowledge, our study is among the first to directly compare Bacteroides of black and white women. We also observed that the Weekly Stress Inventory measure, a measure of ongoing chronic stress was inversely associated with Bifidobacterium. We also observed racial differences in the WSI with white women reporting a higher number of stressful events and a greater impact. After controlling for stress, the racial difference in Bacteroides persisted with black women having a higher abundance which is of note based on previous research where colorectal cancer patients display higher abundances of Bacteroides than cancer-free individuals."

Note: Let's discuss impact on both fetal and infant Bacteroides capable of skewing immune response to vaccines leading to injury. Also how this research overlaps with miscarriage and research:
https://www.facebook.com/share/p/17YSYXDQ8Z/

31/01/2026

30/01/2026

HIGH-DOSE VITAMIN D
HOW AND WHERE DOES IT WORK?

"Vitamin D3 supplementation changed the gut microbiome in the upper GI tract (gastric corpus, antrum, and duodenum). We found a decreased relative abundance of Gammaproteobacteria including Pseudomonas spp. and Escherichia/Shigella spp. and increased bacterial richness."

What's mechanism behind vitamin D3 in both COVID prevention and treatment? Reducing Proteobacteria in the proximal small intestine appears key, as it's known the virus binds Proteobacteria, LPS and TLR4.
"Vitamin D3 supplementation changed the gut microbiome in the upper GI tract (gastric corpus, antrum, and duodenum). We found a decreased relative abundance of Gammaproteobacteria including Pseudomonas spp. and Escherichia/Shigella spp. and increased bacterial richness. No major changes occurred in the terminal ileum, appendiceal or***ce, ascending colon, and sigmoid colon or in stools, but the CD8+ T cell fraction was significantly increased in the terminal ileum."
Note: CD8+ are natural killer T cells (NKT) required for antiviral immunity. One study found them actually lowered by mRNA vaccine by 33%, which authors had audacity to describe as a "mild" decrease.

'Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract' (2015)
https://link.springer.com/article/10.1007/s00394-015-0966-2

Note: Let's explore the latest on VDRs of immune cells like NKT cells, and how that can shift flora in the right direction.

30/01/2026

Vitamin D is well known for its effects on bone mineralisation but has also been attributed immunomodulatory properties. It positively influences human health, but in vivo data describing vitamin D effects on the human gut microbiome are missing. We aimed ...

30/01/2026

Purpose Vitamin D is well known for its effects on bone mineralisation but has also been attributed immunomodulatory properties. It positively influences human health, but in vivo data describing vitamin D effects on the human gut microbiome are missing. We aimed to investigate the effects of oral v...

30/01/2026

New Review delves into the inner-outer space of the small intestine, far from sterile as often assumed, arguably the most important part of the body:
'Small intestinal microbiota: from taxonomic composition to metabolism'
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(24)00056-8

"In addition to the core microbiota, other segment-specific members commonly found include Neisseria, Granulicatella, Gemella, Rothia, and Actinomyces in the duodenum and the jejunum, and Bacteroides, Escherichia–Shigella, Ruminococcus, Bifidobacterium, Clostridium, and Lactobacillus in the ileum (Figure 1)."

"Currently, aspiration of the intestinal fluid, as well as biopsy and luminal brushing, are the most commonly used small intestinal sampling methods. In addition to their invasive nature, these sample collection techniques have several drawbacks such as cross contamination, bowel preparation, and restriction to the proximal small intestine [6.]. Sampling during surgical procedures, or through ileostomy pouches, allows to minimise contamination but cannot be applied to healthy individuals [6.]. Recently, less invasive techniques using ingestible sampling capsules have been developed. They might allow to profile the full length of the digestive tract with minimal physiological disturbances [7.]. However, the inaccurate location of the sampled sites, as well as the potential contamination, are major limitations of these devices even though the coating is specifically designed to address these issues [7.]."

Let's talk about the global childhood growth stunting pandemic. The real pandemic addressed inadequately by the Gates Foundation where less than 2% of the budget goes toward sanitation and nutrition solutions.

30/01/2026

'Association between serum 25-hydroxyvitamin D status and respiratory tract infections requiring hospital admission: unmatched case-control analysis of ethnic groups from the United Kingdom Biobank cohort'

NHS data from 36,258 people is evaluated as part of the study led by the University of Surrey.

30/01/2026

Stanford Medicine
October, 2025:

Sean Spencer, MD, PhD, instructor of medicine, explores how he treats patients with challenging gastrointestinal issues, working with them to heal their guts...