The GUT CLUB

01/10/2025

Pancreatic cancer by far the highest risk in new research:
https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-025-00831-w/tables/1

Note: Korean findings appear consistent with Yale research::
https://www.facebook.com/share/p/1SyrtNb8K1/

https://www.facebook.com/share/p/1JHV3dGv8k/

01/10/2025

This isn't just about T1D and microbiota, it's also about pandemic-related pancreatic cancer found to be the leading cancer in new Covid shot research from Korea, and by a long shot (2.25x).
https://www.facebook.com/share/p/17poFDyXVc/
Why would pancreatic cancer be so prevalent? Is there a particularly strong autoimmune component relative to other cancers (which were found also stunningly high risk)?
Based on Yale research about immune dysregulation caused by the shots, a picture for pancreatic cancer is painted in deep red.
https://www.facebook.com/share/p/1SyrtNb8K1/

T1D and MICROBIOTA
'Antibiotics, gut microbiota, environment in early life and type 1 diabetes' (2017)
https://pmc.ncbi.nlm.nih.gov/articles/PMC5392439/

"How do antibiotics affect pancreatic beta cell autoimmunity: gut microbiota composition is altered after antibiotic (NPS) treatment and antigen presenting cells exposed to the altered bacteria in the gut display impaired antigen presenting ability to CD8 T cells, which in turn alleviate insulitis in the pancreas and protect the host from diabetes development."

"Early-life treatment using vancomycin reduced the incidence of diabetes in one study (52) but accelerated diabetes in another (27). The discrepancy may be attributed to different treatment protocols. However, the protection in Hansen’s study was accompanied by an increase in the level of Akkermansia, which was later reported to be correlated with a pro-diabetic effect (85, 86). A gluten-free diet can also reduce inflammation and diabetes incidence in NOD, with elevated abundance of Akkermansia. Adding gluten to the gluten-free diet reversed the protection, accompanied by a decreased level of Akkermansia (86). More recently, a study showed that Akkermansia mediate glucose tolerance via IFNγ (87) using loss-and-gain-of-Akkermansia muciniphila approaches in IFNγ knock-out mice. In a clinical study, a 4-day treatment with broad-spectrum antibiotics (Vancomycin, Gentamicin and Meropenem) significantly shifted the gut microbiota composition but this did not have a clinical impact in respect of metabolic markers such as glucose tolerance or insulin secretion (88). However, in a study by Endesfelder and coauthors a change of gut microbiota occurring as a result of dietary change had an impact on islet autoimmunity. The authors stratified the children in the study based on the microbial communities identified. They found that it was possible to detect functional associations between the diet consumed, the microbiome and development of autoimmunity. They identified a subgroup of children where Bacteroides was dominant, with low Akkermansia in the gut microbiota and this was associated with early introduction of a non-milk diet, lower abundance of genes for the production of butyrate and early autoantibody development (89, 90). They postulated that low butyrate generation by the bacteria contributed to increased risk of the development of islet autoantibodies (90)."

"5. F***l microbiota transfer (FMT) as a potential therapy
Gut bacterial composition may be altered by diet, antibiotics, probiotics, or by direct microbiota transfer. F***l microbiota transfer (FMT) has proven to be a effective way to transfer “healthy” microbiota, that may have beneficial effects on metabolism and the immune system in recipient mice (30, 95). FMT has also been used in patients with colitis (96–98) and recently in cancer patients (99, 100). We recently demonstrated that FMT could restore the gut microbiota and rebalance the gut hemeostasis, which in turns delayed diabetes onset in NOD mice (26, 29)."

Note: This is credence for the pharmaceutical industry as major cause of T1D.

More here:
https://www.facebook.com/thegutclub23/posts/pfbid02hNE3o6i1gF3WXfTE4RcnRWNLiDrR9sQvhfRYuQE7wUm8cVWy67VEPW1rEMkWYy8Nl

https://www.facebook.com/photo/?fbid=1177236104459668&set=a.433819348801351

And here regarding T1D related to pancreatic cancer and the pandemic:
https://www.facebook.com/share/p/1BNcin14VG/

https://www.facebook.com/share/p/1SyrtNb8K1/

https://www.facebook.com/share/p/1JHV3dGv8k/

01/10/2025

01/10/2025

https://www.facebook.com/share/17WXVwiyVM/?mibextid=wwXIfr

Sophia Loren cooking. (1960s)

30/09/2025

MCAS 2024:
'Butyrate, Valerate, and Niacin Ameliorate Anaphylaxis by Suppressing IgE-Dependent Mast Cell Activation: Roles of GPR109A, PGE2, and Epigenetic Regulation'
https://journals.aai.org/jimmunol/article/212/5/771/266607/Butyrate-Valerate-and-Niacin-Ameliorate

"oral administration of butyrate and valerate ameliorated IgE-mediated anaphylaxis in mice and that SCFAs significantly reduced the degree of IgE-induced degranulation and cytokine production of bone marrow–derived MCs (BMMCs). We also investigated the molecular mechanisms underlying the suppressive effects of SCFAs in vitro and in vivo by examining the roles of GPR109A, HDACi activity, the NRF2 pathway, and PGs in the effects of SCFAs on MCs. Based on the current results, we concluded that butyrate and valerate regulated MCs via GPR109A and by the HDACi activity, with the accelerated synthesis of PGE2, resulting in the amelioration of anaphylaxis."

"Changes in dietary habits in Japan in the past few decades, from a typical Japanese diet including nattō and high-fiber dishes to Western diets may be associated with the incidence of allergic diseases. We intend to investigate the relationship between the mucosal environment and immunoregulation by focusing on valerate, butyrate, and branched SCFAs, which may lead to the proposal of the health benefits of certain foods in the near future."

"Short-chain fatty acids (SCFAs) are produced by the intestinal microbiota during the fermentation of dietary fibers as secondary metabolites. Several recent studies reported that SCFAs modulate the development and function of immune-related cells. However, the molecular mechanisms by which SCFAs regulate mast cells (MCs) remain unclear. In the current study, we analyzed the function and gene expression of mouse MCs in the presence of SCFAs in vitro and in vivo. We found that the oral administration of valerate or butyrate ameliorated passive systemic anaphylaxis and passive cutaneous anaphylaxis in mice. The majority of SCFAs, particularly propionate, butyrate, valerate, and isovalerate, suppressed the IgE-mediated degranulation of bone marrow–derived MCs, which were eliminated by the Gi protein inhibitor pertussis toxin and by the knockdown of Gpr109a."

30/09/2025

Welcome to The GUT CLUB, where both personal and planetary health is matter of microbial balance.

And a personalized approach to balance:
'Gut-microbiota-targeted diets modulate human immune status'
(August 2021)
https://www.cell.com/cell/fulltext/S0092-8674(21)00754-6

Full paper:
"Given the distinct responses of participants to these two diets, whether a diet composed of both high-fiber and fermented foods could synergize to influence the host microbiota and immune system is an exciting possibility that remains to be determined."
http://metsysbio.com/journalClub/20220825/paper.pdf

30/09/2025

-Cofactor in tryptophan synthesis and conversion to serotonin, as well as vitamin K
“Another pathway influenced by Mg is the serotoninergic system. Mg acts like a cofactor for tryptophan hydroxylase, intervenes in serotonin receptor binding in vitro and exhibits a direct enhancing effect on 5-HT1A serotonin receptor transmission”

Magnesium-HP We proudly promote Magnesium-HP (pure magnesium glycinate).$15 discount and free shipping! Our discount code is GUTCLUB15The GUT CLUB takes magnesium seriously, and from a microbiota-gut-centric view. Looking at magnesium through this lens inspires magnesium supplementation, as if it we...

30/09/2025

Planning to create Blue Corn Lupini Nachos, your input appreciated…

30/09/2025

Lupini

A BEAN with even MORE PROTEIN than soy. But with a DANGEROUS past! A MUST TRY! It's......Lupini Beans!Yes, Mary's Test Kitchen is finally revisiting the clas...