The GUT CLUB

25/11/2025

https://www.allergicliving.com/2025/11/20/rfk-jr-plans-vaccine-and-food-allergy-study-science-disagrees/

Robert F. Kennedy Jr. wants to study aluminum adjuvants and food allergies, despite no science on a link. Inside the controversial take.

24/11/2025

https://youtu.be/QmDY6Kz5-Pw?si=B7vI4aP2usG9cUEL

SARS-CoV-2 might be hiding in your gut bacteria—making spike proteins and mutating like a phage. What does this mean?What if SARS-CoV-2 isn’t just infecting ...

24/11/2025

https://www.sciencedirect.com/science/article/pii/S295019462500086X

The antiparasitic ivermectin (IVM) has been widely used in human and veterinary medicine since 1988, due to its effectiveness in combating various par…

24/11/2025

Singing!

On the verge of his 100th birthday, Dick Van D**e sits down with TODAY’s Al Roker to talk about his new book called “100 Rules for Living to 100: An Optimist...

24/11/2025

"Overall, our data suggested that calcitriol, by lowering pro-inflammatory cytokine production in the T cells from the female and male healthy subjects, was able to reduce the inflammatory status independent of the s*x. However, calcitriol, which induced the expression of IL-10 only in the T cells from the females, seemed to prevent the onset of inflammation in a s*x-specific manner. Further and deeper analyses will clarify whether the increase in IL-10 production could be responsible for the s*x differences in the anti-inflammatory effects of calcitriol. Moreover, which T cell subset is responsible for the increased IL-10 production should also be investigated to better clarify the mechanisms underlying the s*x differences in the vitamin D effects." (2022)

Hypovitaminosis D is involved in various inflammatory, infectious and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Moreover, the active form of vitamin D, calcitriol, has been shown to modulate the immune response, playing an anti-inflammatory effect. However little is kn...

24/11/2025

Let's talk about s*xual differences in microbiota.

Might higher Bacteroides in females explain reduced risk of autism? 5x more autism in males. Update 11/28/17: it explains reduced risk of asthma in baby girls where baby boys suffering asthma have reduced levels of Lactobacillus.

Perhaps naturally higher female levels of Bifidobacteria cross-feeds Bacteroides to influence immune response.

2025 update: Bacteroides can be lower in females:
https://www.facebook.com/photo?fbid=1133204278862851&set=a.433819348801351

24/11/2025

Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut bacterial tolerance. Based on these biological functio...

24/11/2025

24/11/2025

S*x differences in vitamin D metabolism, serum levels and action - Volume 128 Issue 11

24/11/2025

24/11/2025

UKRAINE CONSTIPATION in females may be matter of relatively reduced magnesium-dependent tryptophan synthesis in Bacteroides:

'S*x differences in the phylum‐level human gut microbiota composition' (2021)
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-021-02198-y

"total n = 2301 sample of relatively healthy individuals from Ukraine."

"The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between s*xes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones."

"The F/B ratio was significantly increased in females compared to males."

Note: overlaps with high rates of rheumatoid arthritis known high in females.

24/11/2025

https://pubmed.ncbi.nlm.nih.gov/27210415/

Male fetus and neonates show increased immune vulnerability compared to females, which results in a higher risk of perinatal infections. These differences could partially be due to s*x steroids differential modulation of vitamin D metabolism; since calcitriol, the most active vitamin D metabolite, r...