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22/02/2023

Can I donate blood if I have high cholesterol?

Want to know that can you donate blood if you have high cholesterol levels? So, to answer this common question, let’s take a closer look.

06/01/2023

Is High Cholesterol Hereditary?

If you have a close relative, such as a parent, sibling or grandparent, with high cholesterol, then you are more likely to have high cholesterol yourself. This is mainly due to parents passing on genes that increase blood cholesterol levels to their children, such as genes that code for defective re...

28/11/2022

Try Pasta In Your Cholesterol-Lowering Diet

Almost everyone appreciates a good plate of pasta. This is especially true if you are a person who lives and breathes all things pasta. However, if you've recently been diagnosed with high LDL cholesterol, chances are you're on a cholesterol-lowering diet. However, following a cholesterol-lowering d...

06/09/2022

Is Cholesterol In Your Food A Concern?

It has long been said that cholesterol in food, called dietary cholesterol, affects the level of cholesterol in the body. Well, let's pretend that myth has been busted. Science now speaks for itself, but the flaws have been misplaced for a long time. There are other factors in our diet that can easi...

25/08/2022

What do cholesterol levels mean?

"Cholesterol not only travels in the blood, but it is also transported with specific lipoproteins, such as HDL, for good cholesterol, and LDL, for bad cholesterol, or low-density lipoproteins," José Luis Palma, vice president of the Heart Foundation (FEC), explained."

09/06/2022

9 Tips For Limiting Cholesterol In Your Diet

Foods high in cholesterol also tend to be high in saturated fat and other unhealthy fats, so it's important to limit the amount of cholesterol in your diet.

08/06/2022

How Does Cholesterol Relate To Cardiovascular Disease?

Cholesterol, also known as lipids, is a type of fat that circulates in the bloodstream. It is produced naturally by the body and has many important functions.

07/06/2022

High Cholesterol And Heart Disease In Women

Cholesterol builds up in the arteries of the heart and is a major risk factor for heart disease - the leading cause of death - and a reliable source of information for women.

06/06/2022

6 Tips When Starting Treatment For High Cholesterol Levels

Looking for the Best Treatment Option For High Cholesterol? Read our Blog & you will know which treatment is best & When To Start Treatment For Cholesterol.

05/06/2022

The Liver And Cholesterol: What You Need To Know

The liver is the largest gland in the body and is located in the upper right corner of the abdomen. It is a master at detoxifying drugs and foreign substances from the body. It stores glycogen, which serves as a source of energy for the body. It is also important for the metabolism of fats, carbohyd...

04/06/2022

Some Of The Symptoms Associated With High Cholesterol Levels Should Not Be Ignored

Some Of The Symptoms Associated With High Cholesterol Levels Should Not Be Ignored High cholesterol has no particular symptoms and can only be detected by blood tests. Now, there are some subtle signs that can help you detect it. Cholesterol is a waxy substance found in blood fats. Many people only....

03/06/2022

How Do You Know If Your Cholesterol Is Too High?

Everyone has cholesterol, which is a yellowish-white waxy lipid (also called fat) found in every cell in the body. Cholesterol contributes to the proper functioning of cells and organs. It also plays an important role in the production of hormones, vitamins, and digestive juices.

02/06/2022

Is There Cholesterol In Egg Whites?

When it comes to egg whites, it's true that the white part of the egg contains no cholesterol. A large whole egg contains 186 mg of cholesterol, but that's all in the yolk, or the yellow part of the egg.

01/06/2022

Helpful Information Regarding Welchol (Colesevelam)

Suffering from high cholesterol levels and thinking about starting Welchol? Here’s some useful information that you should know!Cholesterol, LDL cholesterol, HDL cholesterol, cholesterol medicationWelchol, also termed as Colesevelam, is a medication prescribed to lower high levels of cholesterol i...

31/05/2022

What Are Fats? What Do You Need To Know About The Role Of Fat In Your Diet?

What Are Fats? What Do You Need To Know About The Role Of Fat In Your Diet? The type and amount of fat in your diet affects the level of cholesterol in your blood. High levels of cholesterol in the blood are a risk factor for coronary heart disease. Which do you prefer? A juicy […]

31/05/2022

High Cholesterol Foods – Avoid Unhealthy Foods

If cholesterol levels are high, intake of visceral organs such as the liver, heart, brain, intestines, and kidneys should be completely restricted. Similarly, people with high cholesterol should not eat meat patties because they are also sausages.

24/05/2022

Can I Test My Cholesterol At Home?

Did you know that you can have your cholesterol levels checked at home? Home cholesterol test kits are available and can be used between appointments with your health care provider.

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Want to know what exactly is the cholesterol hypothesis and if it’s even valid after all these years? Here’s some information

Majority of the cardiologists in the healthcare profession have long championed the “cholesterol hypothesis.” This hypothesis, put simply, states that the high levels of LDL cholesterol are an immediate cause for atherosclerosis. Therefore, improving your high LDL cholesterol levels is a crucial step in reducing the risk of getting atherosclerotic cardiovascular disease.

As a matter of fact, for years, healthcare professionals have highlighted the importance of altering diets for improving elevated cholesterol levels. While on the other hand, pharmaceutical organizations have invested billions of dollars in developing and testing cholesterol medications.

Thus, the cholesterol hypothesis has become entrenched not only among healthcare professionals but also the general population.

It might, therefore, be surprising to hear that many cardiologists are now questioning the validity of this hypothesis. And even though this debate has mainly taken place behind closed doors among professionals, it still doesn’t take away from the relevance and vigor of this argument. Hence, the cholesterol hypothesis isn’t a settled science, despite the public proclamation by some of the prominent healthcare experts.

What Exactly Is the Cholesterol Hypothesis?

The cholesterol hypothesis rests on two important premises. The first premise is that according to the pathologists cholesterol deposits in the body are one of the major constituents of the atherosclerotic plaques. Second, as per the epidemiological studies, individuals with elevated levels of cholesterol have a higher risk of developing cardiovascular disease.

Similarly, in the randomized clinical trials conducted in 1990s, individuals with high levels of cholesterol showed improved results when treated with the statin medications. All of this, therefore, helped prove to the cardiologists and other healthcare professionals that cholesterol hypothesis is indeed valid.

What Are Some New Doubts That Have Arisen About the Cholesterol Hypothesis?

However, with time the validity of the cholesterol hypothesis has been called into question. This is mainly due to the fact that several clinical trials where the individuals were given medications other than the statins, didn’t show any significant improvements.

Therefore, if the cholesterol hypothesis were to be accurate, then those individuals would have shown significant improvements, irrespective of the cholesterol-lowering medication administered to them.

However, this is not what was observed. To clarify it further, in the trials where individuals were given medications other than statins, such as niacin, fibrates, CETP inhibitors and so on, they failed to show any improvement in the cardiovascular outcome.

Hence, it can be stated in cholesterol-lowering clinical trials; cardiovascular outcomes are only improved when the individuals are administered statin medications. All of this, therefore, casts serious doubt on the credibility of the cholesterol hypothesis.

Over here, it’s also crucial to mention that these doubts were made public in 2013 in the form of a publication. This publication listed new guidelines for controlling the cholesterol levels by focusing on which individuals should be treated with statin medications. As a matter of fact, for many individuals, these new guidelines cautioned against using non-statin medications to lower elevated levels of cholesterol. Thus, these new guidelines discarded the classical form of the cholesterol hypothesis to create a major controversy within the healthcare community.

What Is the Reasoning Behind Completely Discarding the Cholesterol Hypothesis?

The reasoning behind completely giving up on the cholesterol hypothesis is that, if elevated levels of LDL cholesterol are the immediate cause of atherosclerosis, then lowering these levels of LDL cholesterol by any type of medication should by default improve the cardiovascular outcomes. However, after the results from various randomized cholesterol-lowering clinical trials, this result wasn’t observed. Therefore, the cholesterol hypothesis must be false.

But where does that even leave the statins, you might ask? To answer the question; statins don’t improve the cardiovascular risk by lowering the levels of elevated cholesterol per se. Instead, they do so through the help of other non-cholesterol effects.

What Is the Reasoning Behind Revising the Cholesterol Hypothesis?

On the other hand, some of the healthcare experts strongly express their contention against discarding the importance of cholesterol levels. This is because they hold the idea that no matter how you choose to cut your cholesterol levels when it comes to cardiovascular disease, cholesterol will always be important.

To clarify this statement further; the atherosclerotic plaques contain cholesterol. And, when you try to reduce the elevated levels of LDL cholesterol in your body, the atherosclerotic process is reduced to some extent. Therefore, it isn’t wise to completely disregard the importance of cholesterol levels and the cholesterol hypothesis.

What Should the Cholesterol Hypothesis Be Revised to?

It’s already clear that cholesterol is crucial to the development of atherosclerotic plaques in your body. It’s also clear that while high levels of LDL cholesterol correlate with the chances of developing atherosclerosis, there’s more to this than just your blood levels.

This is because not every individual with elevated LDL cholesterol levels develops atherosclerosis, nor do all individuals with atherosclerosis have high levels of LDL cholesterol. Thus, it shows us that it isn’t only the blood cholesterol levels that play a part, but rather it also depends upon the type of the lipoprotein particles and their behavior.

Therefore, a new, revised cholesterol hypothesis should factor in things like the LDL, HDL, and lipoproteins and their behavior.

Conclusion

To conclude, it can be seen that the classic cholesterol hypothesis is quite limited and simplistic in its view of cholesterol levels being the sole determiner of the cardiovascular disease. All of this has left the healthcare experts in an unfamiliar place where the hypothesis once used to be.

Thus, keeping all of this in mind, it’s crucial that you don’t forget that significant lifestyle changes and drugs prescribed to you for treating coronary disease have major benefits. However, you should always be careful never to halt your treatment without speaking to your healthcare professional first.

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Want to know what exactly is the cholesterol hypothesis and if it’s even valid after all these years? Here’s some information