theNNT.com

31/05/2025

Most viewed this week from JAMA Cardiology: Chronic cannabis smoking and THC ingestion were associated with endothelial dysfunction similar to that observed in to***co smokers.

https://ja.ma/43CAfvz

31/05/2025

Fixed-Dose Subcutaneous Low-Molecular-Weight Heparin vs. Adjusted-Dose Unfractionated Heparin for Venous Thromboembolism Treatment

Benefits in NNT 143 One in 143 was helped (VTE recurrence within 15 days prevented) 70 One in 70 was helped (VTE recurrence within 3 months prevented) 143 0.7% lower risk of recurrent DVT in in 15 days 70 1.4% lower risk of recurrent DVT in 3 months Harms in NNT 160 One in 160 were harmed (e...

31/05/2025

Endovascular Therapy for Acute Vertebrobasilar Occlusion Stroke

Improved chance of favorable functional outcome (mRS 0–3) and functional independence (mRS 0–2); lower risk of death at 90 days; higher risk of symptomatic intracranial hemorrhage at 24–72 h compared to standard medical treatment

31/05/2025

Corticosteroids for Community-Acquired Pneumonia

Corticosteroids reduced mortality (only for severe CAP), reduced need for invasive mechanical ventilation (intubation) and ICU admission as well as length of hospital and ICU stay

08/05/2025

Targeted grant terminations have affected more than $1.8 billion in NIH funding. Terminations were spread across nearly all NIH institutes and centers, although cuts disproportionately impacted the National Institutes on Minority Health and Health Disparities (30% of all funding).

This study examines the impact of National Institutes of Health grant terminations on the US research enterprise by quantifying the number and funding amount of these terminations and characterizing their award type and institute or center.

31/01/2025

If you want your blood to boil, read this.

Fraud in research needs to end.

23/01/2025

Benefits in NNT Unknown Unknown Harms in NNT 6 1 in 6 were harmed (gastrointestinal events—nausea, vomiting, diarrhea, abdominal discomfort) 6 16% higher risk of gastrointestinal events (nausea, vomiting, diarrhea, or abdominal discomfort) View As: Source MacDonald BJ, Turgeon RD, McCormack J. Met...

23/01/2025

Benefits in NNT No one was helped (no death prevented) No one was helped Harms in NNT No one was harmed (no difference in adverse events) No one was harmed View As: Source Long B, Gottlieb M. Fluid volumes in adults with sepsis. Academic Emergency Medicine. Published online April 3, 2024:acem.14912....

23/01/2025

The effectiveness of nirmatrelvir/ritonavir (Paxlovid) in reducing mortality or hospitalization in mild to moderate COVID-19 is uncertain

23/01/2025

Adding SGLT-2 inhibitors and GLP-1 agonists to standard treatment reduces death, nonfatal heart attack, and severe kidney disease in Type 2 diabetes, but also increases adverse events

23/01/2025

Positive Findings (Patient Has This) Finding Increased Disease Probability (Positive Likelihood Ratio) Rapid plasma reagin (RPR) 4.8–7.6 Fluorescent treponemal antibody-absorption (FTA-ABS) 6-99 Treponema pallidum particle agglutination (TP-PA) 99-215 Negative Findings (Patient Doesn't Have This) ...

23/01/2025

Benefits in NNT 16 1 in 16 women with recurrent UTIs were helped 8 1 in 8 children were helped 9 1 in 9 people with susceptibility to UTI due to a bladder intervention were helped 16 6.25% of women with recurrent UTIs were helped 8 12.5% of children were helped 9 11% of people with susceptibility to...