Hystelica

We are a community built to understand women’s biology for safe and effective psychedelic use

20/10/2025

Although psychedelic integration has not been extensively researched, evidence from multiple related fields suggests that integration frameworks should be gender-sensitive. Preferred methods of integration often vary according to gender and socio-cultural influences. For women, focusing on emotional regulation, self-forgiveness, and interpersonal healing may offer particular benefits. Additionally, having access to an open-minded and supportive community is essential for a successful integration process.

19/10/2025

For decades neuroscience has sought to understand the brain while forgetting half of its biology.
S*x is not a variable to be controlled, it is a dimension that shapes the way neurons connect, respond to stress, and degenerate over time.

New in vitro technologies, from stem cells to organoids and organ on a chip platforms, are finally allowing us to explore these differences with precision. They show that the path to translational and personalized medicine begins long before the clinic: it begins in the lab, in the choice to model both male and female biology with equal care.

*xDifferences

19/10/2025

Psychedelic-like states reported by individuals after a high ventilation breathing session.
If you’d like to find out more, read the full paper here:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0329411

18/10/2025

Menopause is not as comprehensively researched as we’d expect - even when taking into consideration the fact that half of the population will go through it in their lifetime. Non-hormonal therapy for symptoms like hot flushes and psychosocial aspects of this time remain underresearched. This year the theme for World Menopause Month is Lifestyle Medicine, highlighting how our daily choices - everything we do and neglect - shape our health and wellbeing.

If you are someone who uses sub-perceptual doses of psychedelics (microdosing) to manage symptoms of menopause – we’d love to hear from you. Take part in our study on the effects of psychedelics on menopause (see last slide).

For more insight on how microdosing psychedelic substances can affect menopause : https://hystelica.com/hmicrodosing-psychedelic-substances-and-the-menopause/

17/10/2025

It is estimated that 10–12% of women will develop post-traumatic stress disorder (compared to 5–6% of men) at some point in their lives. Biological, hormonal, and psychosocial differences between men and women influence the course of the disorder, symptom presentation, and recovery.

15/10/2025

There’s growing interest in the potential of psychedelics like psilocybin, ket*mine and L*D to help individuals struggling with OCD symptoms. The early research and personal reports suggest that these substances may temporarily reduce obsessive thoughts and compulsive behaviors, possibly by “resetting” rigid thought patterns by quieting down the default mode network. However, the evidence so far is very limited, and we don’t yet know if these effects are safe, lasting, or clinically useful.

For now, we’ll have to wait for more research and clinical trials to understand whether classic psychedelics could really play a role in treating OCD.

14/10/2025

Join us on the 24th of October for Street Drugs Discussions: Women and Drugs.

This online event will focus on an analysis of women's drug use and gaps in research due to misogynistic policy. Hystelica’s founder - Dr. Grace Blest-Hopley- will cover critical gender gaps in psychedelic research, hormonal mechanisms and how they modulate drug use and effects across menstrual & life cycles and need for gender-specific research and personalized treatment protocols.

Get tickets and find out more here:

https://www.eventbrite.co.uk/e/street-drugs-discussions-women-and-drugs-tickets-1767368800659

13/10/2025

🌟 Meet the Panel: Unraveling Chronic Pain: Psychedelics & Women’s Health 🌟

We’re excited to welcome Julia Bornemann as one of our panelists for this event.

Julia is a PhD candidate at the Centre for Psychedelic Research, Imperial College London, where she investigates the therapeutic potential of psychedelics for chronic pain conditions. With a background in neuroscience, she has contributed to several groundbreaking psychedelic trials at Imperial. Her current work explores how psychedelics may transform pain through embodiment, mindfulness, compassion, movement, and meaningful involvement of the public in research.

📅 Webinar: Unraveling Chronic Pain: Psychedelics & Women’s Health
🕑 Date & Time: October 22, 2025 6-8pm BST
🎟️ Tickets: [Link in bio]

12/10/2025

Chemotherapy or ovarian surgery can trigger instant menopause: estrogen levels drop overnight, mood changes intensify, and the body’s rhythm feels suddenly rewritten.

Research shows that abrupt estrogen loss alters serotonin and stress-regulating pathways, contributing to anxiety, low mood, and sleep disruption.
Younger survivors are particularly affected, balancing hormonal upheaval, fertility loss, and the weight of recovery, all at once.

Science is learning to map this complexity and every discovery brings us closer to more compassionate, evidence-based care for women’s minds and bodies.

12/10/2025

You are invited to join us on the 23rd of October for an online event : “Women and Psychedelics: cycles, care and conditions.”
Hear from five incredible voices as they share powerful insights into how women’s health, biology, and lived experience influence the way we connect with psychedelics.

Use the link below to register –

https://open-foundation.org/events/online/women-and-psychedelics-cycles-care-and-conditions/

See you there!

11/10/2025

October is ♀️World Menopause Month ♀️ - time dedicated to menopause and those experiencing it. This month we are focusing on menopause education, highlighting available resources, treatment options, and recent research findings. This celebration has been established by the International Menopause Society (IMS) in collaboration with the World Health Organization (WHO), since 2009.

Take part in our menopause study!

If you’d like to find out more about psychedelics and menopause follow this link - https://hystelica.com/hmicrodosing-psychedelic-substances-and-the-menopause/

10/10/2025

Taking care of your mental health is not optional - it’s essential for a woman’s overall well-being.
October 10th is recognized as World Mental Health Day, and this year’s theme is “Access to Services - Mental Health in Catastrophes and Emergencies.”

The following services offer help during a psychedelic trip:

https://firesideproject.org - offers a free hotline during challenging experiences

https://challengingpsychedelicexperiences.com - UK-based free and confidential online peer support group

Stay safe and take care!

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